Ovarian Cancer: The Neglected Diagnosis

Yawn, Barbara P.; Barrette, Brigitte A.; Wollan, Peter C.

doi:10.4065/79.10.1277

Cited by 40 publications

(24 citation statements)

References 26 publications

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“…Studies that have examined the potential for differential misclassification of fruit and vegetable intake in retrospective studies of cancer suggest that the likelihood of recall bias is generally not high except when study participants have changed their diet, particularly if the diet change was related to disease (9). Because prediagnostic abdominal pain and gastrointestinal upset have been reported in 50% to 70% of women with ovarian cancer (57)(58)(59), it is plausible that dietary habits may change before diagnosis. Thus, the stronger inverse association observed in the case-control studies compared with our study may reflect recall bias.…”

Section: Discussionmentioning

confidence: 99%

Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies

Koushik

Hunter

Spiegelman

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Because fruits and vegetables are rich in bioactive compounds with potential cancer-preventive actions, increased consumption may reduce the risk of ovarian cancer. Evidence on the association between fruit and vegetable intake and ovarian cancer risk has not been consistent. We analyzed and pooled the primary data from 12 prospective studies in North America and Europe. Fruit and vegetable intake was measured at baseline in each study using a validated foodfrequency questionnaire. To summarize the association between fruit and vegetable intake and ovarian cancer, study-specific relative risks (RR) were estimated using the Cox proportional hazards model, and then combined using a random-effects model. Among 560,441 women, 2,130 cases of invasive epithelial ovarian cancer occurred during a maximum follow-up of 7 to 22 years across studies. Total fruit intake was not associated with ovarian cancer risk-the pooled multivariate RR for the highest versus the lowest quartile of intake was 1.06 [95% confidence interval (95% CI), 0.92-1.21; P value, test for trend = 0.73; P value, test for between-studies heterogeneity = 0.74]. Similarly, results for total vegetable intake indicated no significant association (pooled multivariate RR, 0.90; 95% CI, 0.78-1.04, for the highest versus the lowest quartile; P value, test for trend = 0.06; P value, test for between-studies heterogeneity = 0.31). Intakes of botanically defined fruit and vegetable groups and individual fruits and vegetables were also not associated with ovarian cancer risk. Associations for total fruits and vegetables were similar for different histologic types. These results suggest that fruit and vegetable consumption in adulthood has no important association with the risk of ovarian cancer. (Cancer Epidemiol Biomarkers Prev 2005; 14(9):2160 -7)

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Section: Discussionmentioning

confidence: 99%

Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies

Koushik

Hunter

Spiegelman

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Across conditions from HIV to ovarian cancer, misattribution of symptoms is a significant cause of delays in help-seeking (9,10).…”

Section: The Help-seeking Processmentioning

confidence: 99%

Explaining disparities in treatment seeking: the case of infertility

White

McQuillan

Greil

2006

Fertility and Sterility

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“…Researchers from other institutions across the United States and in other countries have found remarkably similar findings. [11][12][13][14] In addition, large population-based studies have identified the majority of ovarian cancer patients as experiencing significant symptoms before diagnosis. [15][16][17][18][19][20] The investigators from the University of Washington did a follow-up case-control study to establish a symptom index that might be useful in the early diagnosis of ovarian cancer.…”

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confidence: 99%

Symptoms Associated With Ovarian Cancer

Goff

2012

Clinical Obstetrics &Amp; Gynecology

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Over the past decade there has been considerable evidence that women with ovarian cancer do have recognizable symptoms before diagnosis. The most common symptoms associated with ovarian cancer are abdominal bloating, increased abdominal size, pelvic pain, abdominal pain, feeling full quickly, and difficulty eating. Some studies also suggest that urinary symptoms are frequently present. When these symptoms occur more than 12 times per month and are of new onset, then ovarian cancer should be considered as a possibility. It is important for women and practitioners to be aware that ovarian cancer is not a "silent disease."

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Ovarian Cancer: The Neglected Diagnosis

Cited by 40 publications

References 26 publications

Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies

Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies

Explaining disparities in treatment seeking: the case of infertility

Symptoms Associated With Ovarian Cancer

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