Ovarian cancer stem cells promote tumour immune privilege and invasion via CCL5 and regulatory T cells

You, Yanan; Li, Yiying; Li, Ming; Lei, M.; Wu, Mengyao; Ying, Qu; Yuan, Yan; Chen, Tong; Jiang, Hua

doi:10.1111/cei.13044

Cited by 56 publications

(36 citation statements)

References 55 publications

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“…Inflammation on one hand provides growth and metastasis opportunities; resolution of inflammation helps the tumor to escape antitumor immunity. Therefore, it is not surprising that many solid tumors including hepatocellular ( 192 ), gastric ( 193 ), lung ( 194 ), breast ( 195 ), ovarian ( 196 ), cervical ( 197 ), and melanomas ( 198 ) summon comparatively large numbers of Tregs which sometimes account for even more than 50% of CD4 + T-cell compartment ( 199 ). For most of the tumors, the presence of high number of Tregs indicates a guarded to grave prognosis.…”

Section: Tumor-infiltrating Regulatory T-cells (Ti-tregs): a Battle Wmentioning

confidence: 99%

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

2018

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CD4+Foxp3+ regulatory T-cells (Tregs) are a unique subset of helper T-cells, which regulate immune response and establish peripheral tolerance. Tregs not only maintain the tone and tenor of an immune response by dominant tolerance but, in recent years, have also been identified as key players in resolving tissue inflammation and as mediators of tissue healing. Apart from being diverse in their origin (thymic and peripheral) and location (lymphoid and tissue resident), Tregs are also phenotypically heterogeneous as per the orientation of ongoing immune response. In this review, we discuss the recent advances in the field of Treg biology in general, and non-lymphoid and tissue-resident Tregs in particular. We elaborate upon well-known visceral adipose tissue, colon, skin, and tumor-infiltrating Tregs and newly identified tissue Treg populations as in lungs, skeletal muscle, placenta, and other tissues. Our attempt is to differentiate Tregs based on distinctive properties of their location, origin, ligand specificity, chemotaxis, and specific suppressive mechanisms. Despite ever expanding roles in maintaining systemic homeostasis, Tregs are employed by large varieties of tumors to dampen antitumor immunity. Thus, a comprehensive understanding of Treg biology in the context of inflammation can be instrumental in effectively managing tissue transplantation, autoimmunity, and antitumor immune responses.

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Section: Tumor-infiltrating Regulatory T-cells (Ti-tregs): a Battle Wmentioning

confidence: 99%

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

2018

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“…Studies had revealed that CCL5 promoted tumor migration and invasion through recruiting M2 type macrophages (TAMs) in breast cancer 32 . Meanwhile, Tregs had been found that it was recruited by CCL5-CCR5 axis in ovarian cancer 45 . CCL5 may have effects on tumor infiltration cells.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, a study identified that zoledronic acid can significantly affect the interaction between Tregs and cancer cells by reducing the expression of CCL5 and CCL2 59 . Furthermore, Tregs, which were recruited by CCL5, promoted the invasion of ovarian cancer cells through matrix metalloproteinase-9 (MMP9), which enhanced the degradation of the extracellular matrix and enabled the invasion of tumor cells, also been identified 45 , 60 . So, this present study demonstrated that a higher expression level of CCL5 is associated with the more abundance of Tregs in KIRC.…”

Section: Discussionmentioning

confidence: 99%

The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma

Bai¹,

Wu²,

Yan³

et al. 2020

Int. J. Med. Sci.

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Background: Kidney renal clear cell carcinoma (KIRC) is the most representative subtype of renal cancer. Immune infiltration was associated with the survival time of patients with tumors. C-C chemokine ligand 5 (CCL5) can promote the malignant process of tumor and be related to infiltration immune cells in some cancers, but not reported in KIRC. Methods: The expression profile and clinical data were obtained from The Cancer Genome Atlas (TCGA) database. The correlation between the expression level of CCL5 and clinical features in KIRC was analyzed. Gene Set Enrichment Analysis (GSEA) was utilized to explore the functions and pathways of CCL5 in KIRC. Then, the analysis between the survival and immune infiltration cells was carried out, as well as the non-parametric tests between the CCL5 expression and the ratios of immune infiltration cells. Results: The correlations between the expression levels of CCL5 in KIRC and clinical features including survival time, pathological stage, grade, and status of the patient, have been identified. Meanwhile, GSEA analysis has shown relationships between the expression of CCL5 and immune pathways. The immune infiltrated cells were correlated with the prognosis of KIRC, especially regulatory T cells (Tregs), mast cells, and dendritic cells. And Tregs was associated with the CCL5 expression. Conclusion: The increased expression of CCL5 is related to poor prognosis and clinical features. Meanwhile, CCL5 is related to Tregs ratios and CCL5 may act as a typical chemokine to recruit Tregs in KIRC. CCL5 could be used as a biomarker for the prognosis prediction and a potential therapeutic target for patients with KIRC.

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“…Studies suggest that CCL14 is involved in the incidence and development of breast and oral cancer (17,18); however, there are no reports that investigate the role of CCL14 in EOC. Studies have demonstrated that CCL5/CCR5 and chemokine (C-X-C) motif ligand 12 (CXCL12) β promote tumor immune tolerance and tumor progression (32,33). CXCL12/CXCR4, CCL18 and CXCL16/CXCR6 can promote the progression and migration of OC (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

C‑C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer

et al. 2020

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Previous studies have demonstrated that CC motif chemokine 14 (CCL14) plays an important role in the occurrence and development of cancer. However, the significance of CCL14 in the progression and prognosis of epithelial ovarian cancer (EOC) has not yet been reported. The standard EnVision procedure for tissue microarrays was used to evaluate the immunohistochemical expression of CCL14 protein in 154 patients with EOC who underwent tumor-debulking operations at the Central Cancer Department of Sun Yat-Sen University (Guangzhou, China) or Jiangmen Central Hospital (Jiangmen, China). The association between CCL14 expression and clinicopathological variables was assessed using the χ 2 test. For survival status of patients with EOC, Kaplan-Meier survival analysis and a Cox multivariate regression model was used. Expression of CCL14 protein was significantly associated with International Federation of Gynecology and Obstetric stage (P=0.014) and pN status(P=0.005). Kaplan-Meier survival analysis revealed that the survival time of patients with high expression of CCL14 was 136.1 months and that of patients with low expression of CCL14 was 98.9 months (P=0.026). Multivariate analysis demonstrated that CCL14 upregulation was associated with overall survival time (HR, 0.48; 95% CI, 0.261-0.896; P=0.021) and progression-free survival time (HR,0.437; 95% CI, 0.228-0.839; P=0.013). In conclusion, CCL14 is an independent prognostic factor for EOC and upregulation of CCL14 is associated with a more favorable prognosis in patients with EOC.

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Ovarian cancer stem cells promote tumour immune privilege and invasion via CCL5 and regulatory T cells

Cited by 56 publications

References 55 publications

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma

C‑C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer

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