Ovarian cancer stem cells: A target for oncological therapy

Markowska, Anna; Sajdak, Stefan; Huczyński, Adam; Rehlis, Sandra; Markowska, Janina

doi:10.17219/acem/73999

Cited by 21 publications

(15 citation statements)

References 37 publications

(48 reference statements)

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“…Additionally, the process of EMT can be triggered by treatment with cisplatin, a standard chemotherapy treatment for ovarian cancer, which is revelatory in the finding that cisplatin can also enrich for ovarian CSCs [28,42]. Therefore, the link between ovarian CSCs, EMT and the tumor relapse and chemoresistance found in ovarian cancer patients following primary treatment, is established [2,3].…”

Section: The Roles Of Ovarian Cancer Stem-like Cells (Cscs) In Metmentioning

confidence: 99%

“…They are the 5th leading cause of cancer deaths among women in the developed world and the most lethal gynecological malignancy [1]. Late diagnoses and an approximately 80% relapse rate after successful primary therapy, are largely responsible for this dreary statistic [2]. The late diagnosis is especially problematic considering that the 5-year survival rate drops from 45% to 25% when diagnosed in advanced stages of tumor progression [3].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis

Bregenzer

Horst

Mehta

et al. 2019

Cancers

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Ovarian cancer is an extremely lethal gynecologic disease; with the high-grade serous subtype predominantly associated with poor survival rates. Lack of early diagnostic biomarkers and prevalence of post-treatment recurrence, present substantial challenges in treating ovarian cancers. These cancers are also characterized by a high degree of heterogeneity and protracted metastasis, further complicating treatment. Within the ovarian tumor microenvironment, cancer stem-like cells and mechanical stimuli are two underappreciated key elements that play a crucial role in facilitating these outcomes. In this review article, we highlight their roles in modulating ovarian cancer metastasis. Specifically, we outline the clinical relevance of cancer stem-like cells, and challenges associated with their identification and characterization and summarize the ways in which they modulate ovarian cancer metastasis. Further, we review the mechanical cues in the ovarian tumor microenvironment, including, tension, shear, compression and matrix stiffness, that influence (cancer stem-like cells and) metastasis in ovarian cancers. Lastly, we outline the challenges associated with probing these important modulators of ovarian cancer metastasis and provide suggestions for incorporating these cues in basic biology and translational research focused on metastasis. We conclude that future studies on ovarian cancer metastasis will benefit from the careful consideration of mechanical stimuli and cancer stem cells, ultimately allowing for the development of more effective therapies.

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Section: The Roles Of Ovarian Cancer Stem-like Cells (Cscs) In Metmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis

Bregenzer

Horst

Mehta

et al. 2019

Cancers

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“…After cisplatin treatment, the dormant cells of human ovarian cancer displayed an augmented expression of cells with Oct-4, nestin, CD-117, and CD44 markers, proving the resistance of this stem cell fraction to cisplatin [102]. Thus, additional treatments with drugs more specific to CSC such as Salinomycin and/or Metformin might be considered [103]. In this line, it could be shown that Salinomycin inhibits NF-κB and induces apoptosis in cisplatin resistant ovarian cancer cells [104].…”

Section: Ovarian Cancer and Cancer Stem Cellsmentioning

confidence: 99%

A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells

Kaltschmidt

Banz‐Jansen

Benhidjeb³

et al. 2019

Cancers

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Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and recurrence in a broad range of human cancers. Although being a key player in cancer development and progression by stimulating proliferation and metastasis and preventing apoptosis, the role of the transcription factor NF-κB in cancer stem cells is still underestimated. In the present review, we will evaluate the role of NF-κB in CSCs of glioblastoma multiforme, ovarian cancer, multiple myeloma, lung cancer, colon cancer, prostate cancer, as well as cancer of the bone. Next to summarizing current knowledge regarding the presence and contribution of CSCs to the respective types of cancer, we will emphasize NF-κB-mediated signaling pathways directly involved in maintaining characteristics of cancer stem cells associated to tumor progression. Here, we will also focus on the status of NF-κB-activity predominantly in CSC populations and the tumor mass. Genetic alterations leading to NF-κB activity in glioblastoma, ependymoma, and multiple myeloma will be discussed.

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“…Cancer stem cells (CSCs), a small population of cancer cells that retain stem cell-like properties [2], account for most of the development of drug resistance and tumor recurrence. CSCs have been proven to be present in various tumors, including those of lung [3], brain [4], breast [5], prostate [6], colon [7], ovarian [8], and head and neck cancer [9]. CSCs are commonly identified by surface and nonsurface biomarkers, which are conserved and specific.…”

Section: Introductionmentioning

confidence: 99%

PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics

Sheng

et al. 2019

BMC Cancer

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Background Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is a great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) is thought to be a novel prognostic factor in several cancers, but its role in LSCC remains unknown. Cancer stem cells (CSCs) are responsible for most instances of tumor recurrence and the development of drug resistance and have been proven to be present in head and neck cancers. Our preliminary study indicated that PLOD2 was elevated in LSCC tissues; therefore, we hypothesized that PLOD2 is related to the prognosis of LSCC patients and aimed to explore the role and underlying mechanism of PLOD2 in LSCC. Methods We validated the prognostic role of PLOD2 in 114 LSCC patients by immunohistochemistry. Stable PLOD2-overexpressing Hep-2 and FaDu cells were established and assessed by molecular biology and biochemistry methods both in vitro and in vivo. Results We confirmed that PLOD2 overexpression was correlated with poor prognosis in LSCC patients. PLOD2 overexpression strengthened the CSC-like properties of Hep-2 and FaDu cells, activated the Wnt signaling pathway and conferred drug resistance in LSCC in vitro and in vivo. Conclusions We found that PLOD2 could serve as a prognostic marker in patients with LSCC and confer drug resistance in LSCC by increasing CSC-like traits; in addition, a Wnt-responsive CSC pathway was identified.

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Ovarian cancer stem cells: A target for oncological therapy

Cited by 21 publications

References 37 publications

The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis

The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis

A Role for NF-κB in Organ Specific Cancer and Cancer Stem Cells

PLOD2 contributes to drug resistance in laryngeal cancer by promoting cancer stem cell-like characteristics

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