Ovarian cancer metastatic to the brain: What is the optimal management?

McMeekin, D. Scott; Kamelle, Scott; Vasilev, Steven A.; Tillmanns, Todd; Gould, Natalie; Scribner, Dennis R.; Gold, Michael A.; Guruswamy, Suresh; Mannel, Robert S.

doi:10.1002/jso.1149

Cited by 52 publications

(74 citation statements)

References 25 publications

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“…However, because of the small cohort size (2-12 patients), extrapolation of these intervals is limited. 30 Our results are also marred by a small sample size of 5 patients, thus limiting the reach of our analysis. A median and mean survivals of 42.3 and 33.6 months, respectively, from study entry were obtained in these patients.…”

Section: Ovarian Metastasismentioning

confidence: 71%

Enhanced chemotherapy delivery by intraarterial infusion and blood‐brain barrier disruption in the treatment of cerebral metastasis

Fortin

Gendron

Boudrias

et al. 2007

Cancer

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Cationic polyurethane‐fluorinated acrylate hybrid dispersions (PUFA) were prepared by the copolymerization of styrene, butyl acrylate, and 2,2,3,4,4,4‐hexafluorobutyl methacrylate in the medium of crosslinked polyurethane via phase inversion polymerization. The said polyurethane was synthesized in acetone from 2,4‐tolyene diisocyanate, N‐methyldiethanolamine, trimethylolpropane, and soft polyester diol block. The influences of hydrophilic monomer on the surface properties, immersion behaviors, particle size and, zeta potential of the dispersions were investigated. The results show that the addition of hydrophilic monomer can be advantaged to the stability of dispersions and yet will increase the surface free energy by more than 19.9%. The PUFA coating films cured at ambient conditions have the lower surface free energy (less than 0.02033 J/m2). At the same time, there is an obvious mobility of fluorinated groups in fluorinated polymer films. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Section: Ovarian Metastasismentioning

confidence: 71%

Enhanced chemotherapy delivery by intraarterial infusion and blood‐brain barrier disruption in the treatment of cerebral metastasis

Fortin

Gendron

Boudrias

et al. 2007

Cancer

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“…This allows metastases at distant sites to implant and grow. Another explanation is the availability of better imaging techniques for the diagnosis of brain metastases [11,[21][22][23][24]. In addition, chemotherapy may cross the blood-brain barrier (BBB) poorly, yet it increases the propensity for CNS metastases.…”

Section: Incidencementioning

confidence: 99%

Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

2006

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Key Words. Brain metastases • Surgery • Stereotactic radiosurgery • Whole-brain radiotherapy • Chemotherapy Learning ObjectivesAfter completing this course, the reader will be able to:1. Select the appropriate treatment strategies for ovarian cancer patients with solitary brain metastases and extracranial disease.2. Describe the most important prognostic factors for ovarian cancer patients with brain metastases.3. List the diagnostic steps needed to establish the diagnosis of brain metastases in ovarian cancer patients.

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“…-уже у 1,3% больных [9]. По данным ряда авторов [9][10][11][12][13][14][15][16][17][18][19][20][21][22], среди метастазов в головном мозге метастазы РЯ составляют от 0,2 до 11,6%. Причиной низкой встречаемости, вероятно, является от-носительно низкая способность серозного РЯ к гемато-генному метастазированию.…”

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Treatment in patients with ovarian cancer metastasizing to the brain

Зайцев¹,

Новикова²,

Kirsanova³

et al. 2015

Onkol. Z. im. P.A. Gercena

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Ключевые слова: метастазы в головном мозге, внутричерепные новообразования, рак яичников.The review gives the data available in the literature on the problem in treating patients with intracranial metastases from ovarian cancer (OC). The incidence of secondary brain involvement in OC has increased 6.5-fold in the last 20 years. The optimal treatment policy for intracerebral metastases from OC remains a complicated problem. If the foci are more than 3 cm, surgical treatment followed by chemotherapy and radiotherapy is recommended. If the foci are smaller, brain stereotactic radiosurgery followed by chemotherapy is the method of choice. The authors' investigation was conducted in 8 patients with brain metastases from OC, who had undergone microsurgical removal of a metastatic brain tumor, followed by multimodality treatment. After multimodality treatment, median overall survival was 15.0 months and median relapse-free survival was 11.5 months. Metastatic brain involvement is traditionally considered as a final manifestation of the disease and characterized by an extremely pessimistic prognosis. Our experience demonstrates that combination treatment involving surgery results in prolonged survival in patients who have a satisfactory quality of life. Keywords: breast cancer, intracranial neoplasms, ovarian cancer. © Коллектив авторов, 2015Кирсанова Ольга

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Ovarian cancer metastatic to the brain: What is the optimal management?

Abstract: OBM portends a poor prognosis, however, long-term survival is possible. Patients appear to benefit from therapy, especially selected groups of OBM patients with single brain metastasis treated with radiation therapy and surgery.

Cited by 52 publications

References 25 publications

Enhanced chemotherapy delivery by intraarterial infusion and blood‐brain barrier disruption in the treatment of cerebral metastasis

Enhanced chemotherapy delivery by intraarterial infusion and blood‐brain barrier disruption in the treatment of cerebral metastasis

Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature

Treatment in patients with ovarian cancer metastasizing to the brain

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