Ovarian cancer: involvement of the matrix metalloproteinases

Al-Alem, Linah; Curry, Thomas E.

doi:10.1530/rep-14-0546

Cited by 81 publications

(81 citation statements)

References 87 publications

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“…As the member of MMPs family, the role of MMP-2 and MMP-9 in prostate cancer has been extensively studied [41], there are still multiple evidence that shed light on the MMPs and their impact on ovarian cancers [42]. …”

Section: Discussionmentioning

confidence: 99%

High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer

Jin

Wang

et al. 2017

Oncotarget

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BackgroundWiskott-Aldrich syndrome verprolin-homologous (WAVE) 3, a member of the WASP/WAVE family of proteins, plays a critical role in cell motility and acts as an oncogene in some human cancers, but no sufficient information available to illustrate its involvement in ovarian cancer tumorigenesis and progression.MethodsThe expression of WAVE3 in human ovarian cancer and normal tissue was analyzed by immunohistochemistry. WAVE3 gene and protein expression in different human ovarian cancer cell lines was tested by RT-PCR and western blotting. Stable cells of WAVE3-knockdown in SKOV3 cells or transfected high expression in A2780 cells were constructed. The WAVE3 expression and its correlation with MMPs, p38 MAPK and other factors were studied. The relationship between WAVE3 and oncogenicity in vivo was also evaluated by nude mice xenograft model.ResultsImmunohistochemistry staining showed the highest WAVE3 expression in ovarian cancer metastases, high in ovarian cancer and weak in normal. In different cell lines, SKOV3 cells showed the highest WAVE3 expression, A2780 cells expressed the lowest. Elevated WAVE3 expression in A2780 cells promoted proliferation and decreased apoptosis, increased the cell number in G2/M phase and promoted migration significantly. Correspondingly, knockdown of WAVE3 in SKOV3 cells showed opposite effects. The WAVE3 expression showed positive correlation with MMPs, NF-κB, COX-2, VEGF and phospho-p38 MAPK, but not p38. The high expression of WAVE3 promoted tumorigenesis in vivo.ConclusionsOur results suggested that WAVE3 may be pivotal in ovarian cancer cell motility, invasion and oncogenesis, which might be related with MMPs production and p38 MAPK pathway.

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Section: Discussionmentioning

confidence: 99%

High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer

Jin

Wang

et al. 2017

Oncotarget

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“…Our data further demonstrated that platycodin D‐treated OSCC cells displayed a significant decline in the expression of MMP‐2 and MMP‐9. Matrix metalloproteinases are a family of proteolytic enzymes that play a fundamental role in cancer cell invasion and metastasis . High expression of MMP‐2 and MMP‐9 is associated with metastatic phenotypes and poor prognosis in OSCC .…”

Section: Discussionmentioning

confidence: 99%

Platycodin D, a triterpenoid saponin from Platycodon grandiflorum , suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway

Zhang

Zhao

Zheng

et al. 2017

J Biochem Mol Toxicol

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This work was undertaken to explore the effects of platycodin D, a triterpenoid saponin from Platycodon grandiflorum, on the growth and invasiveness of human oral squamous cell carcinoma (OSCC). Platycodin D caused a significant, concentration-dependent inhibition of cell viability and induced significant apoptosis in OSCC cells. Moreover, platycodin D significantly inhibited OSCC cell invasion. At the molecular level, platycodin D increased the amounts of IκBα protein and reduced the expression of phosphorylated NF-κB p65, MMP-2, and MMP-9. Ectopic expression of constitutively active NF-κB p65 prevented platycodin D-mediated induction of apoptosis and suppression of invasion in OSCC cells. In vivo studies confirmed that platycodin D retarded the growth of subcutaneous SCC-4 xenograft tumors and reduced phosphorylation of NF-κB p65. Altogether, platycodin D shows inhibitory activity on OSCC growth and invasion through inactivation of the NF-κB pathway and might provide therapeutic benefits in the treatment of OSCC.

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“…122,123 Expression of CD44 and CA125, high levels of IL-6, CXR4, and CXCL12 and the amplification of PIK3CA, Akt and bone morphogenetic protein (BMP) pathways have been associated with ovarian cancer EMT. 17,124,125 The review by Tan et al provides an in-depth look at epithelial ovarian cancer metastasis. 28 Recent clinical studies and xenograft research have shown that side populations of ovarian cancer within the ascites display characteristics of CSCs.…”

Section: Relating In Vitro Mechanotransduction Results To In Vivmentioning

confidence: 99%

Review: Mechanotransduction in ovarian cancer: Shearing into the unknown

2018

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Perspective: The role of mechanobiology in the etiology of brain metastasis APL Bioengineering 2, 031801 (2018) Ovarian cancer remains a deadly diagnosis with an 85% recurrence rate and a 5-year survival rate of only 46%. The poor outlook of this disease has improved little over the past 50 years owing to the lack of early detection, chemoresistance and the complex tumor microenvironment. Within the peritoneal cavity, the presence of ascites stimulates ovarian tumors with shear stresses. The stiff environment found within the tumor extracellular matrix and the peritoneal membrane are also implicated in the metastatic potential and epithelial to mesenchymal transition (EMT) of ovarian cancer. Though these mechanical cues remain highly relevant to the understanding and treatment of ovarian cancers, our current knowledge of their biological processes and their clinical relevance is deeply lacking. Seminal studies on ovarian cancer mechanotransduction have demonstrated close ties between mechanotransduction and ovarian cancer chemoresistance, EMT, enhanced cancer stem cell populations, and metastasis. This review summarizes our current understanding of ovarian cancer mechanotransduction and the gaps in knowledge that exist. Future investigations on ovarian cancer mechanotransduction will greatly improve clinical outcomes via systematic studies that determine shear stress magnitude and its influence on ovarian cancer progression, metastasis, and treatment.

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Ovarian cancer: involvement of the matrix metalloproteinases

Cited by 81 publications

References 87 publications

High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer

High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer

Platycodin D, a triterpenoid saponin from Platycodon grandiflorum , suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-κB pathway

Review: Mechanotransduction in ovarian cancer: Shearing into the unknown

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