Ovarian Cancer in Iran: National Based Study

Abstract

Background: Ovarian cancer (OC) is the 7th most common cancer, with 239,000 new cases per year. In Iran, it is the 8th most common cancer, with an ASIR of 3.9/100,000 women. The 5-year overall survival in Iran based on previous studies is about 61% which in comparison with eastern countries has better survival.
 Methods: The study included patients from the Iran National Cancer Registry from 2009-2014. Several steps were taken to control data quality. This study used a Kaplan-Meier survival curve to compare OC survival rates across geographical, pathological, and other variables. All analyses were done in R (4.02) and SPSS (26), with a 0.05 P-value considered statistically significant.
 Results: The study enrolled 7977 cases of OC. OC's ASIR was 4.10/100,000. In epithelial and non-specific OC, ASIR was >0.5. Five-year survival was 55% and 10-year survival was 45%.
 Conclusion: OC is the 8th most common cancer in Iran, with lower age-specific incidence and better overall survival than East Asia and North America. In Iran, as in Eastern Europe, OC incidence correlated with reduced total fertility rate and population aging. Five and 10-year overall survival rates were 55% and 44%, respectively, higher than the West. This may be because late stage OC patients are excluded from pathology and classified as “undiagnosed” in death certificates or hospitalization files.

Screening ovarian cancer by using risk factors: machine learning assists

“…Iran had 1966 and 1269 new cases and a mortality rate of OC among women in 2020 [ 15 ]. Despite the increasing trend of OC among women due to the decreasing birth rate and increasing elderly population, it has not been suggested as an effective solution for screening this disease [ 16 , 17 ]. OC would be detected at advanced stages due to the asymptomatic nature of this disease at earlier stages, and even differential diagnosis to other maladies at later stages, leading to poor prognosis [ 18 ].…”

Estimation Recurrence Free Survival of the Epithelial Ovarian Cancer Using Classification and Regression Tree

“…Epithelial ovarian cancer is one of the leading causes of death from gynecological cancers in the Western world (4), and only about 40% of women with ovarian cancer survive 5 years after diagnosis (5). In Iran, ovarian cancer is the eighth most common cancer, with an age-standard incidence of 3.9/100,000 (6). Although the five-year survival rate has increased in the last decade, the low survival rate causes recurrence (7).…”