Ovarian and Hypothalamic Control of the Daily Surges of Prolactin Secretion During Pseudopregnancy in the Rat<sup>1</sup><sup>2</sup>

Freeman, Marc E.; Smith, M. Susan; Nazian, Stanley J.; Neill, J. D.

doi:10.1210/endo-94-3-875

Cited by 228 publications

(128 citation statements)

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“…As in PSP, the suppressive effect of PCPA on pregnancy has been reported [16]. The diurnal and nocturnal surges of PRL which are induced by vaginal stimulation or a treatment with reserpine are most important in maintaining rat PSP [2,10]. The nocturnal surge is blocked by PCPA or the serotonin receptor blocker, ketanserin [16].…”

Section: Discussionmentioning

confidence: 99%

Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Maekawa

Yamanouchi

1996

Endocr J

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Abstract. The role of mesencephalic raphe nuclei in the induction of pseudopregnancy was investigated in female rats. The dorsal or median raphe nucleus lesions (DRL or MRL, respectively) were made by means of a radiofrequency lesion generator. Two or 3 weeks after the operation, in order to induce pseudopregnancy, the vagina was stimulated electrically on the day of proestrus or 1 mg/kg b.w. reserpine was injected on the day of diestrus I. Traumatization by passing thread to one uterine horn was performed to induce deciduoma 5 days after vaginal stimulation or 3 days after reserpine injection. As the results, decidual response was seen in most control and sham females in both vaginal stimulation and reserpine-treated groups. In contrast, incidences of deciduoma in DRL females with vaginal stimulation or reserpine-injection were significantly lower than those in control and sham groups. In the MRL females with either vaginal stimulation or reserpine-treatment, incidences of deciduoma were comparable to those of the control and sham operated groups. These results suggest that the dorsal raphe nucleus plays an important role in pseudopregnancy-inducing mechanisms in female rats.

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Section: Discussionmentioning

confidence: 99%

Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Maekawa

Yamanouchi

1996

Endocr J

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“…It is known that prolactin is an initial luteotrophic stimulus for pseudopregnancy in the rat (Freeman et al 1974;Smith et al 1975. When cervical stimulation was given at 1900 h pro-oestrus (12 h light and 12 h dark, lights on at 0600 h), there was a consequential, twice daily release of prolactin (Freeman et al 1974): a nocturnal release occurred between 01 00 and 0900 h and a diurnal release occurred between 1500 and 2100 h , and, during every day of the pseudopregnancy, the nocturnal surge was the greater of the two (Freeman and Neill 1972).…”

Section: Discussionmentioning

confidence: 99%

“…There are a number of possible explanations for this change in responsiveness to cervical stimulation: (1) failure of afferent impulses resulting from cervical stimulation to be transmitted; (2) alteration in luteal sensitivity to prolactin pulses; (3) a change in pituitary response to hypothalamic regulation; or (4) a change in hypothalamic response to afferent impulses triggered by cervical stimulation. Freeman et al (1974) suggested that the reflex was preserved in some mnemonic system because nocturnal surges of prolactin which lasted 6-8 days could be induced in long-term ovariectomized rats given cervical stimulation. However, recent experiments by Murakami et al (1979) have indicated that in the intact rat, production of prolactin surges early in pseudopregnancy was not continued because of a 'memory' and became dependent upon elevated levels of progesterone.…”

Section: Discussionmentioning

confidence: 99%

Critical Time Period for the Vagino-cervical Stimulus to Induce Pseudopregnancy in the Dioestrous Rat

Soares¹,

Wa²

1980

Aust. Jnl. Of Bio. Sci.

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Groups of rats experienced mechanical stimulation of the vagino-cervical region to induce pseudopregnancy at various intervals from 0900 h on dioestrus -1 (D -1) to 1800 h on D -2. Twentyfour of 26 rats which were stimulated on D -I experienced immediate pseudopregnancy whereas when the stimulus was given on D-2, 39 of 45 rats continued to cycle and the latest time when such mechanical stimulation would reliably induce immediate pseudopregnancy was

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“…44: [337][338][339][340][341][342][343] 1998) electrical method [1, 2] or depletion of monoamine by drugs, such as reserpine [3,4] causes pseudopregnancy (PSP) in rats. In the PSP, the prolactin surge occurs by these artificial methods as in pregnancy [5,6] and makes a conditioning of uteri for decidual formation. These indicate an importance of the central nervous system for rat pregnancy in the first half-period.…”

mentioning

confidence: 99%

“…In the PSP, the prolactin surge occurs by these artificial methods as in pregnancy [5,6] and makes a conditioning of uteri for decidual formation. These indicate an importance of the central nervous system for rat pregnancy in the first half-period.…”

mentioning

confidence: 99%

Differential Effects of Dorsal Raphe Nucleus Lesions on Pseudopregnancy Induced by Reserpine or Vaginal Stimulation in Female Rats.

Maekawa

Yamanouchi

1998

Journal of Reproduction and Development

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Abstract. The role of the dorsal raphe nucleus in the maintenance of pseudopregnancy induced by reserpine and/or vaginal stimulation was investigated in female rats. In order to induce pseudopregnancy, either the vagina was stimulated electrically (VS) on the day of proestrus, or 1 mg/kg b.w. reserpine (R) was injected on the day of diestrus I. In some females, both VS and R treatments (VS+R) were applied. Radiofrequency lesions were made in the dorsal raphe nucleus (DRL) 5 days after VS and 3 days after R. At the same time, the left uterine horn was traumatized in order to induce deciduoma. As a result, positive decidual responses were seen in most control and sham-control rats with VS or R-treatments. In contrast, the incidence of deciduoma in DRL females with R injection was lower than that in control and sham groups, but the incidence in DRL females with VS or VS+R was comparable to that in control and sham females. These results suggest that the dorsal raphe nucleus plays an important role in maintaining the mechanism of pseudopregnancy induced by reserpine, but not in that induced by vaginal stimulation. Key words: Dorsal raphe nucleus, Pseudopregnancy, Deciduoma, Vaginal stimulation, Reserpine, Lesion.(J. Reprod. Dev. 44: [337][338][339][340][341][342][343] 1998) electrical method [1, 2] or depletion of monoamine by drugs, such as reserpine [3,4] causes pseudopregnancy (PSP) in rats. In the PSP, the prolactin surge occurs by these artificial methods as in pregnancy [5,6] and makes a conditioning of uteri for decidual formation. These indicate an importance of the central nervous system for rat pregnancy in the first half-period. Thus, analysis of the PSP in rats may deepen our understanding of the difference of the pseudopregnancy-regulating mechanisms among species in an evolutional view. The basic regulatory mechanism for PSP involves the preoptic area (POA) and the medial basal hypothalamus (MBH) in rats, because destruction of he pregnancy is maintained by the luteal function in the first half-period of it. The corpus T luteum independently secretes progesterone responsible for the maintenance of pregnancy in many mammals such as a human. On the other hand, for progesterone secretion in this half-period of pregnancy, the stimulation of the corpus luteum by prolactin surges from the pituitary is required in the rat. Furthermore, in the rat, the onset of pregnancy requires coital stimulation as reflex ovulation. Instead of coital stimulation, artificial vaginal stimulation (VS) by mechanical or

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Ovarian and Hypothalamic Control of the Daily Surges of Prolactin Secretion During Pseudopregnancy in the Rat¹²

Cited by 228 publications

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Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Critical Time Period for the Vagino-cervical Stimulus to Induce Pseudopregnancy in the Dioestrous Rat

Differential Effects of Dorsal Raphe Nucleus Lesions on Pseudopregnancy Induced by Reserpine or Vaginal Stimulation in Female Rats.

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Ovarian and Hypothalamic Control of the Daily Surges of Prolactin Secretion During Pseudopregnancy in the Rat12

Cited by 228 publications

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Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Effects of Chronic Lesions in Mesencephalic Raphe Nuclei on Induction of Pseudopregnancy.

Critical Time Period for the Vagino-cervical Stimulus to Induce Pseudopregnancy in the Dioestrous Rat

Differential Effects of Dorsal Raphe Nucleus Lesions on Pseudopregnancy Induced by Reserpine or Vaginal Stimulation in Female Rats.

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Ovarian and Hypothalamic Control of the Daily Surges of Prolactin Secretion During Pseudopregnancy in the Rat¹²