Ovarian and Adrenal Contribution to Peripheral Androgens During the Menstrual Cycle

Abraham, Guy E.

doi:10.1097/00006254-197503000-00016

Cited by 75 publications

(112 citation statements)

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“…This is the first time that such information has been reported. Previous investigations indicate that basal serum DHEA-s and testosterone concentrations do not vary among the luteal and follicular phases (Abraham 1974;Schijf et al 1993). In OC users (untrained and trained groups), prolonged exercise also induces an increase in androgen concentrations.…”

Section: Discussionmentioning

confidence: 95%

“…The few available studies in this field are usually not well controlled, due to the confounding variables related to the menstrual cycle, the use of contraceptives, and the ecological nature of many studies (Baker et al 1982;Bonen and Keizer 1987;Filaire et al 1998). In women, the basal concentrations of testosterone and DHEA-s in plasma are influenced by hormonal changes in the menstrual cycle and the use of oral contraceptives (OC) (Abraham 1974;Coenen et al 1995Coenen et al , 1996Massafra et al 1999;Murphy et al 1990;Wiegratz et al 1995).…”

Section: Introductionmentioning

confidence: 99%

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Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

et al. 2009

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The objective of this study was to ascertain the effects of menstrual cycle, oral contraception, and training status on the exercise-induced changes in circulating DHEA-sulphate and testosterone in young women. Twenty-eight healthy women were assigned to an untrained group (n = 16) or a trained group (n = 12) depending on their training background. The untrained group was composed of nine oral contraceptive users (OC+) and seven eumenorrheic women (OC-). The trained group was composed of OC+ subjects only. All the OC+ subjects were taking the same low-dose oral contraception. Three laboratory sessions were organised in a randomised order: a prolonged exercise test until exhaustion, a short-term exhaustive exercise test, and a control session. Blood specimens were collected before, during and after the exercise tests and at the same time of the day during the control session. Basal circulating testosterone was significantly lower in trained as compared to untrained subjects. In all subjects, the prolonged exhaustive exercise induced a significant increase in circulating DHEA-s and testosterone. The short-term exercise induced a significant increase in circulating DHEA-s in untrained eumenorrheic and in trained OC users only. Menstrual phases in OC- did not influence the responses. It was found that exhaustive physical exercise induced an increase in circulating DHEA-s and testosterone in young women. Oral contraception may limit short-term exercise-induced changes.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

et al. 2009

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“…Biochemical pathways and regulation for synthesis and secretion of adrenal androgens differ greatly between males and females; in females, the synthesis of DHEA and DHEAS occur exclusively in the adrenal cortex in responses to adrenocorticotrophin (ACTH) (Abraham 1974;Orentreich et al 1984). DHEA is rapidly cleared from the blood at a rate of approximately 2,000 l/day, while DHEAS has a much slower clearance of about 13 l/day (Longcope 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Although basal concentration of testosterone in females is low compared with males, that of DHEAS is approximately equal in males and females (Baulieu 1996). In females, androgens are for the greater part derived from the adrenal cortex and peripheral conversion from DHEA (Abraham 1974). It may suggest that the large variability of DHEAS level can be attributed to metabolic conversion during training.…”

Section: Discussionmentioning

confidence: 99%

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Aizawa

Akimoto

Inoue

et al. 2003

European Journal of Applied Physiology

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This study examined changes among young females of resting serum dehydroepiandrosterone sulfate (DHEAS) concentration after an 8-week period of resistance training. Nineteen healthy untrained young females [training group: age 18.9 (0.3) years, n=10, control group: age 19.3 (1.0) years, n=9; mean (SD)] were recruited in this study. The training group participated in an 8-week resistance training program (2 days per week on nonconsecutive days). The control group did not involve in any resistance training or regular exercise during the study period. Muscular strength, anthropometry, and resting hormonal levels were measured before and after training in both groups. Serum concentrations of DHEAS, dehydroepiandrosterone (DHEA), testosterone and cortisol were measured by radioimmunoassay. Body mass (2.4%) and lean body mass (2.4%) were significantly increased in the training group ( P<0.05), but not in the control group. The training also significantly increased one-repetition maximum (1-RM) values ( P<0.05). In the training group, resting concentration of serum DHEAS significantly increased after training ( P<0.05). Percent change of DHEAS in the training group was greater than that of the control group ( P<0.05). In the training group, the change of DHEAS level was positively correlated with the change of lean body mass during the training ( r=0.61; P<0.05). Serum DHEA, testosterone and cortisol concentrations did not change in either group during the training. The dramatic increase of resting serum DHEAS concentration after training indicates that DHEAS might be an anabolic hormone marker of adaptation to resistance training among young females. Results are presented as mean (SD).

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“…Dexamethason supprimiert die adrenale Ausschüttung von DHEA und Kortisol [1]. Während jedoch Kortisol eine vollständige Supprimierbarkeit aufweist, findet sich von DHEA noch ca.…”

Section: Introductionunclassified

Indikation zur Hormonsubstitution mit Dehydroepiandrosteron (DHEA) und Wachstumshormon

Bamberger

2002

Gynäkologe

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Ovarian and Adrenal Contribution to Peripheral Androgens During the Menstrual Cycle

Cited by 75 publications

References 0 publications

Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

Effects of menstrual cycle, oral contraception, and training on exercise-induced changes in circulating DHEA-sulphate and testosterone in young women

Resting serum dehydroepiandrosterone sulfate level increases after 8-week resistance training among young females

Indikation zur Hormonsubstitution mit Dehydroepiandrosteron (DHEA) und Wachstumshormon

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