Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents

Jenkins, Lisanne M.; Chiang, Jessica J.; Vause, Katherine; Hoffer, Lauren; Alpert, Kathryn I.; Parrish, Todd B.; Miller, Gregory E.; Wang, Lei

doi:10.1016/j.nicl.2020.102187

Cited by 7 publications

(5 citation statements)

References 52 publications

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“…With regards to depressive symptoms, there was evidence of specificity with regards to associations within parahippocampal and inferior temporal regions that were not observed for PLEs or anxiety symptoms. Middle temporal regions involved in memory processing and encoding predicted depressive symptoms, including parahippocampal and entorhinal area, with primary projections to the hippocampus, along with middle temporal thickness, consistent with theories of depression and endophenotypes related to memory and recall (Goldstein & Klein, 2014), and with previous neuroimaging findings (Bora et al, 2012;Hubachek, 2021;Jenkins et al, 2020).…”

Section: Depressive Symptomatologysupporting

confidence: 85%

Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood

Vargas

Mittal

2022

Psychol. Med.

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Background Gray matter morphometry studies have lent seminal insights into the etiology of mental illness. Existing research has primarily focused on adults and then, typically on a single disorder. Examining brain characteristics in late childhood, when the brain is preparing to undergo significant adolescent reorganization and various forms of serious psychopathology are just first emerging, may allow for a unique and highly important perspective of overlapping and unique pathogenesis. Methods A total of 8645 youth were recruited as part of the Adolescent Brain and Cognitive Development study. Magnetic resonance imaging scans were collected, and psychotic-like experiences (PLEs), depressive, and anxiety symptoms were assessed three times over a 2-year period. Cortical thickness, surface area, and subcortical volume were used to predict baseline symptomatology and symptom progression over time. Results Some features could possibly signal common vulnerability, predicting progression across forms of psychopathology (e.g. superior frontal and middle temporal regions). However, there was a specific predictive value for emerging PLEs (lateral occipital and precentral thickness), anxiety (parietal thickness/area and cingulate), and depression (e.g. parahippocampal and inferior temporal). Conclusion Findings indicate common and distinct patterns of vulnerability for varying forms of psychopathology are present during late childhood, before the adolescent reorganization, and have direct relevance for informing novel conceptual models along with early prevention and intervention efforts.

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Section: Depressive Symptomatologysupporting

confidence: 85%

Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood

Vargas

Mittal

2022

Psychol. Med.

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“…Functional magnetic resonance imaging (fMRI) studies have shown that sleep-deprived people have altered emotional brain networks, mainly in the limbic system (5). Compared with healthy people, the volume, activity and functional connections of the amygdala, insula, cingulate area and prefrontal lobe in patients with emotional disorders, such as various types of anxiety and bipolar disorder, are significantly changed, which further confirms that these are the main brain areas responsible for the related emotions (7)(8)(9). Correlations between these brain regions and emotion have mainly been identified in studies of people with CSD, but a growing number of studies show that ASD has a wide range of effects on emotion (10,11).…”

Section: Introductionmentioning

confidence: 78%

Relation of Decreased Functional Connectivity Between Left Thalamus and Left Inferior Frontal Gyrus to Emotion Changes Following Acute Sleep Deprivation

Cao

Zhang

et al. 2021

Front. Neurol.

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Objective: The thalamus is a key node for sleep-wake pathway gate switching during acute sleep deprivation (ASD), and studies have shown that it plays a certain role in emotion changes. However, there are no studies on the association between the thalamus and emotion changes in ASD. In this study, we used resting-state functional magnetic resonance imaging (R-fMRI) to explore whether changes in the functional connections between the thalamus and other brain regions are related to emotion changes and further explored the function of the thalamus under total ASD conditions.Method: Thirty healthy, right-handed adult men underwent emotional assessment according to the Profile of Mood States Scale and R-fMRI scans before and after ASD. The correlations between changes in functional connectivity between the thalamus and other brain regions and emotion changes were then studied.Results: Positive emotions and psychomotor performance were reduced, and negative emotions were increased following ASD. The functional connections between the left thalamus and left middle temporal gyrus, left inferior frontal gyrus, right thalamus, right inferior temporal gyrus, left middle temporal pole gyrus, right calcarine, left cuneus, left rectus and left medial superior frontal gyrus were significantly altered. Decreased functional connectivity between left thalamus and left inferior frontal gyrus related to emotion changes following ASD.Conclusion: This study finds that functional changes in the thalamus are associated with emotion changes during ASD, suggesting that the left thalamus probably plays an essential role in emotion changes under ASD conditions.

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“…These studies support that the right medial superior frontal gyrus is involved in depressive and somatic symptoms. The thalamus activated during experiencing and regulating emotional distress [ 60 ] and engaged in subclinical depressive symptoms [ 61 ]. The thalamus was also related to sensory processing [ 62 , 63 ], which might play a role in somatic symptoms.…”

Section: Discussionmentioning

confidence: 99%

Somatic symptoms mediate the association between subclinical anxiety and depressive symptoms and its neuroimaging mechanisms

et al. 2022

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Background Subclinical anxiety, depressive and somatic symptoms appear closely related. However, it remains unclear whether somatic symptoms mediate the association between subclinical anxiety and depressive symptoms and what the underlying neuroimaging mechanisms are for the mediating effect. Methods Data of healthy participants (n = 466) and participants in remission of major depressive disorder (n = 53) were obtained from the Human Connectome Project. The Achenbach Adult Self-Report was adopted to assess anxiety, depressive and somatic symptoms. All participants completed four runs of resting-state functional magnetic resonance imaging. Mediation analyses were utilized to explore the interactions among these symptoms and their neuroimaging mechanisms. Results Somatic symptoms partially mediated the association between subclinical anxiety and depressive symptoms in healthy participants (anxiety→somatic→depression: effect: 0.2785, Boot 95% CI: 0.0958–0.3729; depression→somatic→anxiety: effect: 0.0753, Boot 95% CI: 0.0232–0.1314) and participants in remission of MDD (anxiety→somatic→depression: effect: 0.2948, Boot 95% CI: 0.0357–0.7382; depression→somatic→anxiety: effect: 0.0984, Boot 95% CI: 0.0007–0.2438). Resting-state functional connectivity (FC) between the right medial superior frontal gyrus and the left thalamus and somatic symptoms as chain mediators partially mediated the effect of subclinical depressive symptoms on subclinical anxiety symptoms in healthy participants (effect: 0.0020, Boot 95% CI: 0.0003–0.0043). The mean strength of common FCs of subclinical depressive and somatic symptoms, somatic symptoms, and the mean strength of common FCs of subclinical anxiety and somatic symptoms as chain mediators partially mediated the effect of subclinical depressive symptoms on subclinical anxiety symptoms in remission of MDD (effect: 0.0437, Boot 95% CI: 0.0024–0.1190). These common FCs mainly involved the insula, precentral gyri, postcentral gyri and cingulate gyri. Furthermore, FC between the triangular part of the left inferior frontal gyrus and the left postcentral gyrus was positively associated with subclinical anxiety, depressive and somatic symptoms in remission of MDD (FDR-corrected p < 0.01). Conclusions Somatic symptoms partially mediate the interaction between subclinical anxiety and depressive symptoms. FCs involving the right medial superior frontal gyrus, left thalamus, triangular part of left inferior frontal gyrus, bilateral insula, precentral gyri, postcentral gyri and cingulate gyri maybe underlie the mediating effect of somatic symptoms.

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Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents

Cited by 7 publications

References 52 publications

Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood

Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood

Relation of Decreased Functional Connectivity Between Left Thalamus and Left Inferior Frontal Gyrus to Emotion Changes Following Acute Sleep Deprivation

Somatic symptoms mediate the association between subclinical anxiety and depressive symptoms and its neuroimaging mechanisms

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