Outstanding protein-repellent feature of soft nanoparticles based on poly(N-(2-hydroxypropyl) methacrylamide) outer shells

Oliveira, Fernando A. de; Albuquerque, Lindomar J. C.; Riske, Karin A.; Jäger, Eliézer; Giacomelli, Fernando C.

doi:10.1016/j.jcis.2020.04.048

Cited by 15 publications

(11 citation statements)

References 64 publications

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“…[15] This feature notably attenuates the therapeutic effect of PEG-based formulations and therefore, the searching for PEG alternatives is highly relevant. [16] In this framework, a variety of possible substitutes have been investigated including, for instance, poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA) [17], poly(glycerols) [18] and poly(2-oxazoline)s (POx). [19] Truly, despite the literature reports concerning diblock copolymers containing POx, block copolymers combining poly(2-methyl-2-oxazoline) (PMeOx) and the highly valuable pH-switchable block PDPA has been only reported by us to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Oliveira

Batista

Albuquerque

et al. 2023

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Oliveira

Batista

Albuquerque

et al. 2023

Journal of Colloid and Interface Science

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“…storage and sterilization of pine pollen, kaempferol were obviously lost (Figure6d). N-(2-hydroxypropyl) methacrylamide, as a water-soluble monomer, has a wide range of applications in the construction of polymer anti-tumor drug carriers(de Oliveira et al, 2020). This compound detected in YNS may be due to environmental factors during the pollen collection process, and its content was reduced during further processing andstorage.…”

mentioning

confidence: 99%

Analysis of the effect of sterilization and storage on the quality of Pinus yunnanensis pollen based on untargeted metabonomics

Mei

Changjun

Song

et al. 2021

J. Food Process. Preserv.

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Pine pollen refers to the male reproductive cells of Pinus massoniana Lamb., Pinus tabulaeformis Carr., Pinus thunbergii Parl., and Pinus densiflora. It is rich in diverse proteins, amino acids, vitamins, minerals, dietary fiber, lipids, peptides, and flavonoids (Dai et al., 2019) and has various bioactivities (Luo et al., 2012;Mao et al., 2012). Fresh pine pollen is difficult to store because of high water content, so it is essential to be dried and sterilized. Sun et al. (2007) studied the influences of electrothermal drying and circulating hot air drying on black pine and red pine pollen and the result showed that the water content met the requirements of the first-grade pine pollen (6.0% and 5.2%) after drying at 45 and 55°C for 6 hr. Simultaneously, they could keep the quality, shape, and sensory characteristics of pine pollen. Li et al. (2015) optimized the parameters of pine pollen microwave drying and sterilization technology via the response surface method and found that after the optimized process, the water content of pine pollen was 4.23%, and the numbers of bacteria and mold were 2.43 × 10 4 and 23.72 CFU/g, respectively. Drying treatment could reduce the water content of pine pollen, thereby prolonging the shelf life of pollen. Li and Zhou (2017) also found that low temperature (−20°C) could extend the storability of pine pollen. Since traditional heat sterilization will cause changes in food nutrition and flavor substances to some extent, especially some heat-sensitive substances. So non-heat sterilization technology has received more attention in recent years. Common non-heat sterilization included ultrahigh pressure and irradiation sterilization. These methods are equally commonly used to sterilize pine pollen. Initial studies had

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“…The size patterns do not change in 24 h suggesting that the NPs are highly stable against aggregation in the simulated physiological media (Figure 12, left, magenta lines) [70]. The slight increase in diameter (~8-10 nm) is generally attributed to the adsorption of a protein monolayer (corona), because the average size of the dissolved single proteins is ≈8 nm [71,72], as evidenced by the small peak observed at the region of ~10 nm diameter (Figure 12, red and magenta lines). Because we previously demonstrated that the stability of PTX-loaded PLA NPs is limited to a ~2-3% w drug /w polymer drug feeding by nanoprecipitation [48], we selected a 2% w drug /w polymer drug feeding for this experiment.…”

Section: Paclitaxel-loaded Bc3 Nanoparticles and Paclitaxel Releasementioning

confidence: 97%

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

et al. 2023

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This paper introduces a new class of amphiphilic block copolymers created by combining two polymers: polylactic acid (PLA), a biocompatible and biodegradable hydrophobic polyester used for cargo encapsulation, and a hydrophilic polymer composed of oligo ethylene glycol chains (triethylene glycol methyl ether methacrylate, TEGMA), which provides stability and repellent properties with added thermo-responsiveness. The PLA-b-PTEGMA block copolymers were synthesized using ring-opening polymerization (ROP) and reversible addition–fragmentation chain transfer (RAFT) polymerization (ROP-RAFT), resulting in varying ratios between the hydrophobic and hydrophilic blocks. Standard techniques, such as size exclusion chromatography (SEC) and 1H NMR spectroscopy, were used to characterize the block copolymers, while 1H NMR spectroscopy, 2D nuclear Overhauser effect spectroscopy (NOESY), and dynamic light scattering (DLS) were used to analyze the effect of the hydrophobic PLA block on the LCST of the PTEGMA block in aqueous solutions. The results show that the LCST values for the block copolymers decreased with increasing PLA content in the copolymer. The selected block copolymer presented LCST transitions at physiologically relevant temperatures, making it suitable for manufacturing nanoparticles (NPs) and drug encapsulation-release of the chemotherapeutic paclitaxel (PTX) via temperature-triggered drug release mechanism. The drug release profile was found to be temperature-dependent, with PTX release being sustained at all tested conditions, but substantially accelerated at 37 and 40 °C compared to 25 °C. The NPs were stable under simulated physiological conditions. These findings demonstrate that the addition of hydrophobic monomers, such as PLA, can tune the LCST temperatures of thermo-responsive polymers, and that PLA-b-PTEGMA copolymers have great potential for use in drug and gene delivery systems via temperature-triggered drug release mechanisms in biomedicine applications.

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Outstanding protein-repellent feature of soft nanoparticles based on poly(N-(2-hydroxypropyl) methacrylamide) outer shells

Cited by 15 publications

References 64 publications

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Analysis of the effect of sterilization and storage on the quality of Pinus yunnanensis pollen based on untargeted metabonomics

Smart Poly(lactide)-b-poly(triethylene glycol methyl ether methacrylate) (PLA-b-PTEGMA) Block Copolymers: One-Pot Synthesis, Temperature Behavior, and Controlled Release of Paclitaxel

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