Outstanding protein-repellent feature of soft nanoparticles based on poly(N-(2-hydroxypropyl) methacrylamide) outer shells

Oliveira, Fernando A. de; Albuquerque, Lindomar J. C.; Riske, Karin A.; Jäger, Eliézer; Giacomelli, Fernando C.

doi:10.1016/j.jcis.2020.04.048

Cited by 14 publications

(5 citation statements)

References 64 publications

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“…[15] This feature notably attenuates the therapeutic effect of PEG-based formulations and therefore, the searching for PEG alternatives is highly relevant. [16] In this framework, a variety of possible substitutes have been investigated including, for instance, poly[N-(2-hydroxypropyl) methacrylamide] (PHPMA) [17], poly(glycerols) [18] and poly(2-oxazoline)s (POx). [19] Truly, despite the literature reports concerning diblock copolymers containing POx, block copolymers combining poly(2-methyl-2-oxazoline) (PMeOx) and the highly valuable pH-switchable block PDPA has been only reported by us to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Oliveira

Batista

Albuquerque

et al. 2023

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Oliveira

Batista

Albuquerque

et al. 2023

Journal of Colloid and Interface Science

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“…Even small changes, for example, in polymer chemical nature or length (degree of polymerization, DP), can dramatically change antifouling behavior, which can have either a detrimental or beneficial impact on poly mersome properties. [19][20][21] In addition, other characteristics such as polymer flexibility, dispersity (Đ), glass transition temperature, membrane fluidity, surface density, and the nature of the polymer end group could all potentially influence protein interactions on polymersome surfaces.…”

Section: Introductionmentioning

confidence: 99%

Block Length‐Dependent Protein Fouling on Poly(2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior

Najer

Belessiotis‐Richards

Kim

et al. 2022

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Polymersomes are vesicular structures self‐assembled from amphiphilic block copolymers and are considered an alternative to liposomes for applications in drug delivery, immunotherapy, biosensing, and as nanoreactors and artificial organelles. However, the limited availability of systematic stability, protein fouling (protein corona formation), and blood circulation studies hampers their clinical translation. Poly(2‐oxazoline)s (POx) are valuable antifouling hydrophilic polymers that can replace the current gold‐standard, poly(ethylene glycol) (PEG), yet investigations of POx functionality on nanoparticles are relatively sparse. Herein, a systematic study is reported of the structural, dynamic and antifouling properties of polymersomes made of poly(2‐methyl‐2‐oxazoline)‐block‐poly(dimethylsiloxane)‐block‐poly(2‐methyl‐2‐oxazoline) (PMOXA‐b‐PDMS‐b‐PMOXA). The study relates in vitro antifouling performance of the polymersomes to atomistic molecular dynamics simulations of polymersome membrane hydration behavior. These observations support the experimentally demonstrated benefit of maximizing the length of PMOXA (degree of polymerization (DP) > 6) while keeping PDMS at a minimal length that still provides sufficient membrane stability (DP > 19). In vitro macrophage association and in vivo blood circulation evaluation of polymersomes in zebrafish embryos corroborate these findings. They further suggest that single copolymer presentation on polymersomes is outperformed by blends of varied copolymer lengths. This study helps to rationalize design rules for stable and low‐fouling polymersomes for future medical applications.

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“…storage and sterilization of pine pollen, kaempferol were obviously lost (Figure6d). N-(2-hydroxypropyl) methacrylamide, as a water-soluble monomer, has a wide range of applications in the construction of polymer anti-tumor drug carriers(de Oliveira et al, 2020). This compound detected in YNS may be due to environmental factors during the pollen collection process, and its content was reduced during further processing andstorage.…”

mentioning

confidence: 99%

Analysis of the effect of sterilization and storage on the quality of Pinus yunnanensis pollen based on untargeted metabonomics

Mei

Changjun

Song

et al. 2021

J. Food Process. Preserv.

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Pine pollen refers to the male reproductive cells of Pinus massoniana Lamb., Pinus tabulaeformis Carr., Pinus thunbergii Parl., and Pinus densiflora. It is rich in diverse proteins, amino acids, vitamins, minerals, dietary fiber, lipids, peptides, and flavonoids (Dai et al., 2019) and has various bioactivities (Luo et al., 2012;Mao et al., 2012). Fresh pine pollen is difficult to store because of high water content, so it is essential to be dried and sterilized. Sun et al. (2007) studied the influences of electrothermal drying and circulating hot air drying on black pine and red pine pollen and the result showed that the water content met the requirements of the first-grade pine pollen (6.0% and 5.2%) after drying at 45 and 55°C for 6 hr. Simultaneously, they could keep the quality, shape, and sensory characteristics of pine pollen. Li et al. (2015) optimized the parameters of pine pollen microwave drying and sterilization technology via the response surface method and found that after the optimized process, the water content of pine pollen was 4.23%, and the numbers of bacteria and mold were 2.43 × 10 4 and 23.72 CFU/g, respectively. Drying treatment could reduce the water content of pine pollen, thereby prolonging the shelf life of pollen. Li and Zhou (2017) also found that low temperature (−20°C) could extend the storability of pine pollen. Since traditional heat sterilization will cause changes in food nutrition and flavor substances to some extent, especially some heat-sensitive substances. So non-heat sterilization technology has received more attention in recent years. Common non-heat sterilization included ultrahigh pressure and irradiation sterilization. These methods are equally commonly used to sterilize pine pollen. Initial studies had

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Outstanding protein-repellent feature of soft nanoparticles based on poly(N-(2-hydroxypropyl) methacrylamide) outer shells

Cited by 14 publications

References 64 publications

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Tuning the morphology of block copolymer-based pH-triggered nanoplatforms as driven by changes in molecular weight and protocol of manufacturing

Block Length‐Dependent Protein Fouling on Poly(2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior

Analysis of the effect of sterilization and storage on the quality of Pinus yunnanensis pollen based on untargeted metabonomics

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