Outstanding Effect of Physical Exercise on Endothelial Function Even in Children and Adolescents

Noma, Kazuhiro; Kihara, Yasuki; Higashi, Yukihito

doi:10.1253/circj.cj-17-0291

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Two studies by Czippelova et al did not find a lower RHI in obese groups, but recommended further studies 36 37. Noma et al 38 report the beneficial effects of exercise in paediatric patients and is an important message in reducing future endothelial complications 38. Fusco et al noted preclinical microvascular changes in obese patients compared with controls using LDF but noted no RHI change 39…”

Section: Resultsmentioning

confidence: 99%

Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review

et al. 2023

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ObjectivesEndo Peripheral Artery Tonometry (EndoPAT-2000) is a non-invasive technology for measuring endothelial dysfunction (ED). The reactive hyperaemia index (RHI) is resulted and is low when ED is present. We aim to synthesise the literature on paediatric ED that used Endo-PAT analysis.DesignA comprehensive systematic review was conducted from January 2015 to March 2021. The databases included Cochrane, MEDLINE EBSCO, EMBASE (Ovid), PUBMED and CINAHL EBSCO. Exclusion criteria were: (1) If a study used a different device, for example, (2) If the study had no results. Inclusion criteria were: (1) Published in the English, (2) more than 50% of study subjects were in the paediatric age range, (3) data relevant to paediatric age range children could be extrapolated from all data, where not all study subjects were children.ResultsFollowing the removal of duplicates, 156 articles were initially identified. Following exclusion, 50 articles were included for review. We have subdivided these papers into different systems for ease of reference and have reported our findings in six tables: patients with type 1/2 diabetes, obesity, cardiovascular, respiratory, psychiatric conditions and miscellaneous diseases. For each, the study design, population, control group (if available), RHI results and conclusions were reported.ConclusionsA number of papers using Endo-PAT for children with various chronic diseases have evidence of ED. However, in many cases, there has only been a single cohort study using Endo-PAT. Further studies are required to validate these findings and to help characterise the cardiovascular risk profile of children with chronic disease. Further studies are also required that will characterise more completely the cardiovascular risk profile of these children.Consensus on other vascular risk markers that could be included in future studies is ideal and if accomplished, this would facilitate meta-analyses of studies of relatively rare conditions.

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Section: Resultsmentioning

confidence: 99%

Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review

et al. 2023

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“…A physically inactive (even normal-weight) child may have no symptoms of disease, but evidence of deterioration in vascular health may already be present. 39,40 Although as yet insufficiently studied, there is increasing evidence that the rapidly changing phenotype associated with normal growth and development is accompanied by global changes in gene expression. 41 The pattern of change of gene and epigenetic expression during childhood is likely to influence the response to acute exercise and habitual physical activity.…”

Section: The Pediatric Origins Of Adult Cvdmentioning

confidence: 99%

Exercise-associated prevention of adult cardiovascular disease in children and adolescents: monocytes, molecular mechanisms, and a call for discovery

Radom‐Aizik

2019

Pediatr Res

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Atherosclerosis originates in childhood and adolescence. The goal of this review is to highlight how exercise and physical activity during childhood and adolescence, critical periods of growth and development, can prevent adult cardiovascular disease (CVD), particularly through molecular mechanisms of monocytes, a key cell of the innate immune system. Monocytes are heterogeneous and pluripotential cells that can, paradoxically, play a role in both the instigation and prevention of atherosclerosis. Recent discoveries in young adults reveal that brief exercise affects monocyte gene pathways promoting a cell phenotype that patrols the vascular system and repairs injuries. Concurrently, exercise inhibits pro-inflammatory monocytes, cells that contribute to vascular damage and plaque formation. Because CVD is typically asymptomatic in youth, minimally invasive techniques must be honed to study the subtle anatomic and physiologic evidence of vascular dysfunction. Exercise gas exchange and heart rate measures can be combined with ultrasound assessments of vascular anatomy and reactivity, and near-infrared spectroscopy to quantify impaired O2 transport that is often hidden at rest. Combined with functional, transcriptomic, and epigenetic monocyte expression and measures of monocyteendothelium interaction, molecular mechanisms of early CVD can be formulated, and then translated into effective physical activity-based strategies in youth to prevent adult-onset CVD.

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Lifestyles correlate with stroke recurrence in Chinese inpatients with first-ever acute ischemic stroke

Huang

Lin

et al. 2019

J Neurol

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Outstanding Effect of Physical Exercise on Endothelial Function Even in Children and Adolescents

Cited by 4 publications

References 14 publications

Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review

Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review

Exercise-associated prevention of adult cardiovascular disease in children and adolescents: monocytes, molecular mechanisms, and a call for discovery

Lifestyles correlate with stroke recurrence in Chinese inpatients with first-ever acute ischemic stroke

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