We propose a robust sliding mode control (SMC) scheme for a class of uncertain multi-input and multi-output (MIMO) nonlinear systems with the unknown external disturbance, the system uncertainty, and the backlash-like hysteresis. To tackle the continuous system uncertainty, the radial basis function (RBF) neural network is employed to approximate it. And then, combine the unknown external disturbance, and the unknown neural network approximation error with the affection caused by backlash-like hysteresis as a compounded disturbance which is estimated using the developed nonlinear disturbance observer. The robust sliding mode control based on the nonlinear disturbance observer and RBF neural network is presented to track the desired system output in the presence of the unknown system uncertainty, the external disturbance, and the backlash-like hysteresis. Finally, the designed robust sliding mode control strategy is applied to the near-space vehicle (NSV) attitude dynamics, and simulation results are given to illustrate the effectiveness of the proposed sliding mode control approach.