Outpatient    versus    inpatient follow-up for intrahepatic cholestasis of pregnancy

Özyüncü, Özgür; Örgül, Gökçen; Özten, Gonca; Yurdakök, Murat; Beksaç, Mehmet Sinan

doi:10.5114/ceh.2019.88616

Cited by 8 publications

(5 citation statements)

References 18 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An abdominal ultrasound scan should be performed to examine the liver. The assessment of fetal wellbeing should consist in the monitoring of fetal movements, cardiotocography (CTG), and fetal ultrasound scans [31].…”

Section: Therapy Of Icpmentioning

confidence: 99%

Intrahepatic Cholestasis in Pregnancy: Review of the Literature

Piechota

Jelski

2020

JCM

View full text Add to dashboard Cite

Intrahepatic cholestasis of pregnancy (ICP) is the most common hepatic disorder related to pregnancy in women. It usually develops within the third trimester of pregnancy and presents with pruritus as well as elevated levels of bile acid and/or alanine aminotransferase. Clinical signs quickly resolve after delivery; however, there is a high risk of the disorder recurring in subsequent pregnancies. ICP is associated with an increased risk of perinatal complications (premature birth, respiratory disorders, even stillbirth). Elevated levels of gestational hormones and genetic predispositions are important factors for the development of ICP; among the latter, mutations in hepatobiliary transport proteins (multidrug resistance protein 3-MDR3, bile salt export pump- BSEP) play a major role. Clinical and biochemical symptoms of ICP include pruritus and increased levels of total bile acids (TBA). Serum levels of TBA should be monitored in ICP patients throughout the pregnancy as concentrations above 40 μmol/L, which define that severe ICP isassociated with an increased risk of fetal complications. Therapeutic management is aimed at reducing the clinical symptoms, normalizing maternal biochemistry and preventing complications to the fetus. Pharmacological treatment of intrahepatic cholestasis of pregnancy consists of the administration of ursodeoxycholic acid to lower the levels of TBA and possibly reduce pruritus. If the treatment fails, premature delivery should be considered.

show abstract

Section: Therapy Of Icpmentioning

confidence: 99%

Intrahepatic Cholestasis in Pregnancy: Review of the Literature

Piechota

Jelski

2020

JCM

View full text Add to dashboard Cite

show abstract

“…Similarly, in ammation-related hepatic cell degradation products are probably responsible for the injury to the cellular components of the intercellular matrix, which is very important in maternal-fetal interaction. These events may be the reason for obstetrical complications such as prematurity, chronic impaired fetal perfusion and preeclampsia [15]. The pathogenesis of ICP is investigated.…”

Section: Discussionmentioning

confidence: 99%

The Comparison of Total Bile Acid Concentration and Alcohol Dehydrogenase Activity as Markers of Intrahepatic Cholestasis of Pregnancy

Piechota

Jelski

Orywal

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum total bile acids concentration (TBA) and increased liver enzymes. It is important to recognize the disease in its early stage. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP..Methods: Serum samples were taken from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women. For measurement of ADH we used the spectrofluorometric and photometric methods. Results: The results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and TBA concentration. The total ADH activity was also positively correlated with ALT, AST and TBA. Conclusion: We can state that the activity of class I ADH isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during ICP and is comparable with the value of other markers.

show abstract

“…Similarly, inflammation-related hepatic cell degradation products are probably responsible for the injury of cellular components of the intercellular matrix, which is very important in maternal-fetal interaction. These events may be the reason for obstetrical complications such as prematurity, chronic impaired fetal perfusion and preeclampsia (Ozyuncu et al, 2019). The pathogenesis of ICP is under investigation.…”

Section: Discussionmentioning

confidence: 99%

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

et al. 2021

View full text Add to dashboard Cite

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum bile acids concentration and other liver function tests. ICP is connected with increased risk of fetal mortality, but is unfortunately detected quite late. Therefore, it is important to recognize the disease in its early stages. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP. Methods: Serum samples were taken for routine investigation from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women in the same time of pregnancy. For measurement of class I activity we used the spectrofluorometric methods. The total ADH activitiy was measured by the photometric method. Results: The analysis of results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41.3%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and total bile acids (TBA) concentration. The total ADH activity was also positively correlated with ALT, AST and total bile acids. Conclusion: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during this disease and is comparable with the value of other markers.

show abstract

Outpatient versus inpatient follow-up for intrahepatic cholestasis of pregnancy

Cited by 8 publications

References 18 publications

Intrahepatic Cholestasis in Pregnancy: Review of the Literature

Intrahepatic Cholestasis in Pregnancy: Review of the Literature

The Comparison of Total Bile Acid Concentration and Alcohol Dehydrogenase Activity as Markers of Intrahepatic Cholestasis of Pregnancy

The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

Contact Info

Product

Resources

About