Outpatient transperineal prostate biopsy under local anaesthesia is safe, well tolerated and feasible

Hong, Anne; Hemmingway, Sarah; Wetherell, David; Dias, Brendan Hermenigildo; Zargar, Homayoun

doi:10.1111/ans.17593

Cited by 8 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies [35][36][37][38] totalled a population of 946 men submitted to LATPUS biopsy. These studies were based in Australia, Italy, the Netherlands, and the UK.…”

Section: Demographic and Clinical Informationmentioning

confidence: 99%

“…Pain was evaluated with VAS scale 43 in all four studies. Three studies 35,37,38 mentioned transrectal ultrasound probe insertion scored on average [2-3], but no data is available on the remaining study. 36 In the four studies, LA infiltration ranged between [2-5].…”

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

“…36 In the four studies, LA infiltration ranged between [2-5]. Two studies 35,37 reported first-needle-pass score [2-2.88] on average. Other two 36,38 mentioned [1-3] average during the biopsy procedure.…”

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

“…Other two 36,38 mentioned [1-3] average during the biopsy procedure. Only Hong et al 35 assessed pain post-procedure, with patients scoring 1 on Day 0, and 0 on Day 7 and Day 30.…”

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

“…Three studies 35,36,38 reported timeframes when complications were checked. It varied between 1 and 40 days post-biopsy.…”

Section: Complications Ratesmentioning

confidence: 99%

See 4 more Smart Citations

Complications of local anaesthetic transperineal ultrasound‐guided prostate biopsy: A systematic literature review

Perneta,

Tims,

Simmons

2023

Int J of Uro Nursing

View full text Add to dashboard Cite

The prostate cancer pathway has evolved rapidly over the last decade responding to evidence‐based recommendations. These changes were accelerated further over the last 5 years due to the Covid‐19 pandemic and the antibiotic stewardship policies regarding nosocomial/iatrogenic infections. Local anaesthetic transperineal ultrasound‐guided biopsy is a relatively new technique that became gold‐standard practice for prostate cancer diagnosis due to decreased sepsis rates. However, data that justified its implementation was more focused on its efficacy and clinically significant cancer detection rates, lacking robust methodological complications data, including in some cases the utilization of validated tools to assess complications. In patients subjected to local anaesthetic transperineal ultrasound‐guided prostate biopsies, what are the most recent reported complications? This systematic literature review followed Bettany‐Saltikov and McSherry's Manual guidance for systematic literature reviews. Patient/target, Intervention, Comparison, Outcome (PICO) research method, and Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) were used to structure the search strategy and report results. This review was conducted using PubMed/Medline, Excerpa Medica database (EMBASE), and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases. Inclusion criteria focused on recent studies which matched current national and international prostate cancer pathway guidelines (National Institute for Health and Care Excellence and European Association of Urology). Quality assessments were performed using Critical Appraisal Skills Programme checklists. Four cohort studies were included in this review. A total of 946 men were submitted to local anaesthetic transperineal prostate biopsy. Patient experience showed procedure was tolerated with the most painful part of the procedure being local anaesthetic infiltration with Visual Analogue Score variation [2–5]. Few complications were reported. Haematuria had broad definitions across studies, being difficult to interpret the results of this complication. Only one case reported gross haematuria leading to acute urinary retention. Historically, acute urinary retention was mentioned as one of the main adverse effects of transperineal biopsies. However, in this systematic literature review it had similar incidence as transrectal biopsies, particularly when local anaesthesia was utilized. Lower urinary tract symptoms and erectile dysfunction seemed to not be affected by prostate biopsy procedures, however, more data is required as only two studies addressed these issues. Six urinary tract infection patients were reported (0.63%), and one urosepsis case (0.10%). This seems to demonstrate few urinary infections occur and fewer sepsis cases, particularly when compared with transrectal biopsies data, concurring with previous research. Marginal difference was noted between infection rates with or without antibiotic prophylaxis. Local anaesthetic transperineal ultrasound‐guided prostate biopsies seem to remain a safe procedure from a complications rate point of view. It has been proven before to have fewer urinary tract infections and sepsis episodes. Low‐risk patients can have LATPUS biopsies without antibiotic prophylaxis. High‐risk patients need clinician assessment and judicious utilization of antibiotics. Other complications require further studies with standardized biopsy techniques, clear complication definitions, and use of validated tools to measure complications.

show abstract

“…Four studies [35][36][37][38] totalled a population of 946 men submitted to LATPUS biopsy. These studies were based in Australia, Italy, the Netherlands, and the UK.…”

Section: Demographic and Clinical Informationmentioning

confidence: 99%

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

“…Other two 36,38 mentioned [1-3] average during the biopsy procedure. Only Hong et al 35 assessed pain post-procedure, with patients scoring 1 on Day 0, and 0 on Day 7 and Day 30.…”

Section: Patient Experience (Pain Score)mentioning

confidence: 99%

“…Three studies 35,36,38 reported timeframes when complications were checked. It varied between 1 and 40 days post-biopsy.…”

Section: Complications Ratesmentioning

confidence: 99%

See 3 more Smart Citations

Complications of local anaesthetic transperineal ultrasound‐guided prostate biopsy: A systematic literature review

Perneta,

Tims,

Simmons

2023

Int J of Uro Nursing

View full text Add to dashboard Cite

show abstract

Targeted biopsy of the prostate

Schroeder,

Foster,

Young

et al. 2024

Abdom Radiol

View full text Add to dashboard Cite

Evolution of anxiety management in prostate biopsy under local anesthesia: a narrative review

Vanoli,

Grobet-Jeandin,

Windisch

et al. 2024

World J Urol

View full text Add to dashboard Cite

Introduction and methods Prostate biopsy (PB) is an essential step in the diagnosis and active surveillance of prostate cancer (PCa). Transperineal PB (TP-PB) is now the recommended approach and is mostly conducted under local anesthesia. However, this procedure can potentially cause anxiety for patients, given the oncological context and the fear of peri-procedural pain and complications. The objective of this narrative review is to summarize the currently available tools for the management of peri-interventional anxiety during TP-PB, with a particular emphasis on the potential role of virtual reality (VR) in this setting. Results In TP-PB, preoperative anxiety can lead to increased pain perception, longer procedure time, and decreased patient satisfaction. Pharmacological and non-pharmacological approaches have been explored to reduce anxiety, such as premedication, deep sedation, education, relaxation techniques, hypnosis, and music therapy, albeit with mixed results. VR has recently emerged in the technological armamentarium for managing pain and anxiety, and the efficiency of this technology has been evaluated in various medical fields, including pediatrics, gastroenterology, urology, gynecology, and psychiatry. Conclusion Despite the paucity of available data, VR appears to be a safe and effective technique in reducing anxiety in many procedures, even in frail patients. No studies have evaluated the role of VR in TP-PB. Future research should thus explore the optimal way to implement VR technology and any potential benefits for TP-PB patients.

show abstract

Outpatient transperineal prostate biopsy under local anaesthesia is safe, well tolerated and feasible

Cited by 8 publications

References 33 publications

Complications of local anaesthetic transperineal ultrasound‐guided prostate biopsy: A systematic literature review

Complications of local anaesthetic transperineal ultrasound‐guided prostate biopsy: A systematic literature review

Targeted biopsy of the prostate

Evolution of anxiety management in prostate biopsy under local anesthesia: a narrative review

Contact Info

Product

Resources

About