Outpatient management of missed abortion with vaginal misoprostol*

Heard, M.J.; Stewart, Gayle M.; Buster, John E.; Carson, Sandra Ann; Miller, Harold J.

doi:10.1016/s0029-7844(02)01707-6

Cited by 4 publications

(1 citation statement)

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“…Lower dose regimens of vaginal misoprostol were tested in 2 RCTs and have shown to be less effective in inducing expulsion, but with a similar incidence of nausea. 20,21 A study compared 800µg oral with the same dose of vaginal misoprostol with no difference in efficacy, but the mean time to expulsion was significantly longer in the oral group. 22 Sublingual misoprostol had equivalent efficacy compared with vaginal misoprostol in inducing complete miscarriage, but was associated with more frequent diarrhea.…”

Section: Dosage and Routementioning

confidence: 99%

Role of Misoprostol in Missed Abortion

Chowdhury

Shamim

Begum

et al. 2013

Bangladesh J Obstet Gynaecol

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Introduction:Abortion is one of the most common complications of pregnancy occurring in clinically recognized pregnancies 1 . South Asia (Bangladesh, Nepal, India, Pakistan and Srilanka) being highly populated, resource constrained and underdeveloped region, holds almost one third (30%) of world's maternal deaths and approximately 13% of them are related to abortions and its procedures 2 . There is no exact data of missed abortion in Bangladesh annually. But the annual induced abortion rate in Bangladesh is estimated to be 28 abortions per 1,000 women aged 15-49. Dilatation and evacuation of uterus has been the standard, acceptable approach to early pregnancy failure of a period of 50 years with more than 95% success rate 3 . The overall complication rates with surgical evacuation are between 4 and 10% and consists of cervical injury, uterine perforation, pelvic Review Article Role of Misoprostol in Missed Abortion

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Section: Dosage and Routementioning

confidence: 99%

Role of Misoprostol in Missed Abortion

Chowdhury

Shamim

Begum

et al. 2013

Bangladesh J Obstet Gynaecol

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Misoprostol to treat missed abortion in the first trimester

Gemzell‐Danielsson

León

et al. 2007

Intl J Gynecology & Obste

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Missed abortion in the first trimester is characterized by the arrest of embryonic or fetal development. The cervix is closed and there is no or only slight bleeding. Ultrasound examination shows an empty gestational sac or an embryo/fetus without cardiac activity. Based on a review of the published literature a single dose of 800 microg vaginal misoprostol may be offered as an effective, safe, and acceptable alternative to the traditional surgical treatment for this indication. Alternatively, 600 microg misoprostol can be administered sublingually. After administration of misoprostol, hospitalization is not necessary and the time to expulsion varies considerably. Bleeding may last for more than 14 days with additional days of light bleeding or spotting. The woman should be advised to contact a provider in case of heavy bleeding or signs of infection. A follow-up is recommended after 1 to 2 weeks.

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