Outpatient Autologous Stem Cell Transplantation for Patients With Myeloma

Paul, Thomas M.; Liu, Stephen V.; Chong, Elise A.; Luger, Selina M.; Porter, David L.; Schuster, Stephen J.; Tsai, Donald E.; Nasta, Sunita Dwivedy; Loren, Alison W.; Frey, Noelle V.; Perl, Alexander E.; Cohen, Adam D.; Weiss, Brendan M.; Stadtmauer, Edward A.; Vogl, Dan T.

doi:10.1016/j.clml.2015.05.006

Cited by 31 publications

(36 citation statements)

References 7 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The level of implementation of the protective measures is dramatically different across hospitals and countries (Bevans et al, ; Hicheri et al, ; Lee et al, ). While in Italy there is a tendency to use strict isolation measures, other countries in Europe and USA are claiming limited efficacy of protective isolation (Mank & van der Lelie, ; Russell et al, ) and releasing it for standard double rooms, outpatient care, and home care (Bergkvist, Larsen, Johansson, Mattsson, & Svahn, ; Cantú‐Rodríguez et al, ; Faucher et al, ; Paul et al, ; Ringden et al, ).…”

Section: Introductionmentioning

confidence: 99%

Development and initial validation of a questionnaire to assess patients’ perception of protective isolation following haematopoietic stem cell transplantation

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to develop and psychometrically test a questionnaire assessing patients’ perception of protective isolation following haematopoietic stem cell transplantation (HSCT). The conceptual framework for developing the questionnaire was a three‐dimensional model that emerged from a metasynthesis: isolation‐related suffering, relationship with oneself and relationship with others. Item selection was performed through a focus group, comparison with the findings of two phenomenological studies, and content validity with 22 experts. Cognitive interviews with five patients were used to verify face validity. A validation study was conducted in 10 Italian centres, all members of the Italian Group of stem cell transplant (GITMO). Patients completed the questionnaires between 7 and 9 days post‐transplant. Dimensionality was tested through exploratory factor analysis (EFA). A total of 17 items yielded a content validity index (CVI) of 0.88. Participants included 186 adult patients receiving autologous (48%) or allogeneic (52%) HSCT in protective isolation. The EFA yielded a three‐factor solution, explaining 55% of the variance. The scale showed adequate psychometric properties, with the exception of three items, which were eliminated. Future studies should test the psychometric properties of the questionnaire through confirmatory factor analysis and verify its transcultural validity.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and initial validation of a questionnaire to assess patients’ perception of protective isolation following haematopoietic stem cell transplantation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…37 This association has not been extensively studied in the HSCT population; however, one study comparing outcomes of brief (o 5 days) and prolonged (45 days) in patients undergoing autologous HSCT for MM noted a non-statistically significant increased rate of thrombosis in patients with prolonged hospitalizations (3.7% vs 4.6%). 38 Inherited thombophilias (for example, factor V Leiden, prothrombin gene mutation, protein C or S deficiency) are associated with an increased risk of thrombosis in the general population. 37 In the HSCT population, one prospective study of 171 patients suggested that there is a disproportionate prevalence of inherited thrombophilia in patients with central line-associated thrombosis, 39 while a second study found no correlation between inherited thrombophilias and thrombotic events in HSCT recipients.…”

Section: Incidence and Risk Factors For Vte After Hsctmentioning

confidence: 99%

Venous thromboembolism in hematopoietic stem cell transplant recipients

Chaturvedi

Neff

Nagler

et al. 2015

Bone Marrow Transplant

View full text Add to dashboard Cite

Venous thromboembolism (VTE) is an increasingly recognized problem in the post-hematopoietic stem cell transplantation (HSCT) setting, with a lack of high-quality evidence-based data to recommend best practices. Few patients with hematologic malignancies and even fewer post-HSCT patients were included in randomized trials of VTE prophylaxis and treatment. Prior VTE, GVHD, infections and indwelling venous catheters are risk factors for thrombosis. The increasing use of post-transplant maintenance therapy with lenalidomide in patients with multiple myeloma adds to this risk after autologous HSCT. These patients are also at high risk of bleeding complications because of prolonged thrombocytopenia and managing the competing risks of bleeding and thrombosis can be challenging. This review aims to provide a practical, clinician-focused approach to the prevention and treatment of VTE in the post-HSCT setting.

show abstract

“…Italian patients might over‐rely on hospital care and neglect the wish for being at home with their loved ones to be strictly compliant with physician's orders. However, HSCT has been found to be feasible, beneficial and cost‐effective when performed or followed up at home (Bergkvist et al., ; Cantú‐Rodríguez et al., ; Faucher et al., ; Fernández‐Avilés et al., ; Paul et al., ; Schlesinger et al., ). In a study on transplant outpatients, only 14% of the participants reported feelings of apprehension regarding staying at home (Schulmeister, Quiett, & Mayer, ) while, in another study, HSCT patients in home care felt satisfied and secure (Bergkvist, Larsen, Johansson, Mattsson, & Svahn, ).…”

Section: Discussionmentioning

confidence: 99%