Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: A dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by d-amphetamine

Inglis, Wendy L.; Dunbar, J.S.; Winn, Philip

doi:10.1016/0306-4522(94)90314-x

Cited by 100 publications

(69 citation statements)

References 65 publications

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“…Previous studies have shown that integrity of PPTg is necessary for arousal, attention, motivation and learning, and, particularly interestingly here, stimulus-reward associations (Steckler et al, 1994b). Studies using a variety of conditioning tasks have suggested a role for PPTg in assigning task-specific salience value to cue signals (Inglis et al, 1994(Inglis et al, , 2000Florio et al, 1999;Kippin and van der Kooy, 2003). Consistent with this idea, some PPTg cells in cat were found to respond to conditioned stimuli in a context-dependent way, failing to respond to the same cue when another signal indicated a different task requirement (Dormont et al, 1998).…”

Section: Discussionmentioning

confidence: 77%

“…At the behavioral level, lesions of PPTg impair attention (Inglis et al, 2001) and the learning of associations between a conditioned stimulus and a primary reward (Inglis et al, 1994(Inglis et al, , 2000. Furthermore, some evidence from recordings in cats suggest that PPTg neuronal responses to auditory stimuli may be context dependent (Dormont et al, 1998), indicating a degree of plasticity similar to that seen in DA cell responses to predicted rewards (Schultz, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

181

170

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Midbrain dopamine (DA) neurons respond to sensory cues that predict reward. We tested the hypothesis that projections from the pedunculopontine tegmental nucleus (PPTg) are involved in driving this DA cell activity. First, the activity of PPTg and DA neurons was compared in a cued-reward associative learning paradigm. The majority of PPTg neurons showed phasic responses to the onset of sensory cues, at significantly shorter latency than DA cells, consistent with a PPTg-to-DA transmission of information. However, unlike DA cells, PPTg responses were almost entirely independent of whether signals were associated with rewards. Second, DA neuron responses to the cues were recorded in free-moving rats during reversible inactivation of the PPTg by microinfusion of local anesthetic. The results showed clear suppression of conditioned sensory responses of DA neurons after PPTg inactivation that was not seen after saline infusion or in non-DA cells. We propose that the PPTg relays information about the precise timing of attended sensory events, which is integrated with information about reward context by DA neurons.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pan

Hyland²

2005

J. Neurosci.

181

170

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“…One possibility may be via indirect projections from the ventral striatum to output structures such as the ventral pallidum (VP). The VP sends a substantial GABAergic projection to the brainstem, including the PPT (Inglis et al, 1994;Rye et al, 1988). Activation of MSN inhibitory outputs to the VP would in turn be expected to inhibit VP inhibitory influences on the PPT.…”

Section: Discussionmentioning

confidence: 99%

“…Activation of MSN inhibitory outputs to the VP would in turn be expected to inhibit VP inhibitory influences on the PPT. Although future experiments are required to directly test this hypothesis, it is noteworthy that the PPT is critically involved in mediating the rewarding properties of both intra-VTA and systemically administered nicotine (Corrigall et al, 2001;Lanc¸a et al, 2000;, and is functionally linked to NAshell output pathways (Inglis et al, 1994). Thus, although nicotine reward conditioning induced robust effects on spontaneous FSI vs MSN activity patterns within the NAshell, it is important to note that the VTA contains both DAergic and non-DAergic, largely GABAergic neuronal populations, both of which are activated by nicotine administration (Yin and French, 2000) and send both DAergic and GABAergic projections to the ventral striatum (Van Bockstaele and Pickel, 1995).…”

Section: Discussionmentioning

confidence: 99%

Dopamine Receptor Blockade Modulates the Rewarding and Aversive Properties of Nicotine via Dissociable Neuronal Activity Patterns in the Nucleus Accumbens

Sun

Laviolette

2014

Neuropsychopharmacol

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The mesolimbic pathway comprising the ventral tegmental area (VTA) and projection terminals in the nucleus accumbens (NAc) has been identified as a critical neural system involved in processing both the rewarding and aversive behavioral effects of nicotine. Transmission through dopamine (DA) receptors functionally modulates these effects directly within the NAc. Nevertheless, the neuronal mechanisms within the NAc responsible for these bivalent behavioral effects are presently not known. Using an unbiased conditioned place preference procedure combined with in vivo neuronal recordings, we examined the effects of nicotine reward and aversion conditioning on intra-NAc neuronal sub-population activity patterns. We report that intra-VTA doses of nicotine that differentially produce rewarding or aversive behavioral effects produce opposite effects on sub-populations of fast-spiking interneurons (FSIs) or medium spiny neurons (MSNs) within the shell region of the NAc (NAshell). Thus, while the rewarding effects of intra-VTA nicotine were associated with inhibition of FSI and activation of MSNs, the aversive effects of nicotine produced the opposite pattern of NAshell neuronal population activity. Blockade of DA transmission with a broad-spectrum DA receptor antagonist, a-flupenthixol, strongly inhibited the spontaneous activity of NAshell FSIs, and reversed the conditioning properties of intra-VTA nicotine, switching nicotineconditioned responses from aversive to rewarding. Remarkably, DA receptor blockade switched intra-NAshell neuronal population activity from an aversion to a reward pattern, concomitant with the observed switch in behavioral conditioning effects.

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“…Lesions or chemical inactivation of the PPTg has been found to disrupt reward-related responses, attentional performance, and stimulus-reward associations [134][135][136][137][138][139][140][141][142][143][144][145][146]. Consequently, the execution of conditioned reinforcement paradigms was compromised, but movement, per se, was preserved and subtle motor deficits were only evident if tasks were particularly demanding.…”

Section: The Role Of the Pptg In Predictive Reward Information And Rementioning

confidence: 99%

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Vitale¹,

Capozzo²,

Mazzone³

et al. 2017

Transl Brain Rhythmicity

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The pedunculopontine tegmental nucleus (PPTg) is part of the locomotor mesencephalic region and the reticular activating system (RAS). As such, it is involved in regulating some aspects of the motor control and the wake/sleep cycle, but the way in which it operates is unclear. PPTg neurons respond to a variety of sensory stimuli and to cues that trigger the execution of goal-directed motor acts. In this paper, we discuss data that suggest that in addition to operating via thalamic nuclei, the PPTg may also operate by activating cerebellar nuclei, especially the dentate nucleus. In such a way, an intense and diffuse activation of the cerebral cortex may be achieved. In arousal-demanding reward-related tasks, separate populations of PPTg neurons modulate their discharge pattern to encode, in particular, expectancy and magnitude of reward. These neuronal responses, which should reach thalamic, basal ganglia, and cerebellar nuclei through ascending PPTg fibers are essential for the formation of stimuli-reward associations and action selection. In parallel, PPTg neurons, via descending fibers directed to lower brainstem and spinal motor structures, may automatically influence motor mechanisms and muscle tone in order to cause movements that are executed in a smooth and timely manner. In patients affected by Parkinson's disease, PPTg deep brain stimulation may increase arousal, thus making patients more attentive to behavioral stimuli that trigger motor act, while simultaneously facilitating movement.

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Outflow from the nucleus accumbens to the pedunculopontine tegmental nucleus: A dissociation between locomotor activity and the acquisition of responding for conditioned reinforcement stimulated by d-amphetamine

Cited by 100 publications

References 65 publications

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Pedunculopontine Tegmental Nucleus Controls Conditioned Responses of Midbrain Dopamine Neurons in Behaving Rats

Dopamine Receptor Blockade Modulates the Rewarding and Aversive Properties of Nicotine via Dissociable Neuronal Activity Patterns in the Nucleus Accumbens

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

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