Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes

Abdellatif, Mona Kamal; Elzankalony, Yasser Abdelmageuid; Ebeid, Ahmed Abdelmonsef; Ebeid, Weam Mohamed

doi:10.1155/2019/1698967

Cited by 10 publications

(7 citation statements)

References 32 publications

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“…In addition, the ONL thickness within 1 mm region in early treatment diabetic retinopathy study circles by automated segmentations was not related to either age or SEs [27][28][29][30]. ese findings are similar to those of the current study.…”

Section: Discussionsupporting

confidence: 89%

Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population

Jiang

et al. 2020

Journal of Ophthalmology

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Purpose. To evaluate foveal outer nuclear layer (ONL) thickness and the difference thereof between bilateral eyes and their possible associations with clinical characteristics in a healthy Chinese population. Materials and Methods. Normal subjects were enrolled. Generalized linear models were used to assess the associations of foveal ONL thickness with sex, age, and spherical equivalents (SEs) and the associations of the difference in foveal ONL thickness between bilateral eyes with sex, age, and difference in SEs between bilateral eyes. Results. Totally, 304 subjects were included. The average foveal ONL thickness was 103.19 ± 14.25 (range 70–151) μm in the right eye and 103.90 ± 14.63 (range 69–155) μm in the left eye. The mean difference in foveal ONL thickness between right and left eyes was −0.71 ± 4.36 (range −13 to +12) μm. Men had slightly greater foveal ONL thickness values in both right and left eyes compared with women (both P<0.05); however, some women had a thicker foveal ONL than that of men (85/198 vs. 46/106 in the right eye; 79/198 vs. 52/106in the left eye). Age and SEs were not associated with foveal ONL thickness in either eye (all P>0.05). Sex, age, and difference in SEs between bilateral eyes were not associated with the difference in foveal ONL thickness between bilateral eyes (all P>0.05). Conclusions. Foveal ONL thickness showed wide variation in a normal Chinese population but little difference between bilateral eyes. Both these parameters could not be adjusted by sex, age, SEs, or the SEs difference between bilateral eyes. Thus, in those diseases involving only one eye, the difference or ratio of foveal ONL thickness between the affected eye and normal fellow eye may reflect the actual degree of the disease, rather than the foveal ONL thickness in the affected eye alone.

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Section: Discussionsupporting

confidence: 89%

Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population

Jiang

et al. 2020

Journal of Ophthalmology

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“…Changes in RT were shown to be directly related to choroid thickness and perfusion ( 37 ). Therefore, another possible explanation for the observed results may be related to changes in choroid perfusion to the outer retinal layers.…”

Section: Discussionmentioning

confidence: 99%

Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters

Baker

Safarzadeh

Incognito

et al. 2022

Journal of Applied Physiology

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Cerebral hypoxia is a serious consequence of several cardiorespiratory illnesses. Measuring the retinal microvasculature at high altitude provides a surrogate for cerebral microvasculature, offering potential insight into cerebral hypoxia in critical illness. Additionally, while sex-specific differences in cardiovascular diseases are strongly supported, few have focused on differences in ocular blood flow. We evaluated the retinal microvasculature in males (n=11) and females (n=7) using functional optical coherence tomography at baseline (1,130m) (Day 0), following rapid ascent (Day 2) and prolonged exposure (Day 9) to high altitude (3,800m). Retinal vascular perfusion density (rVPD; an index of total blood supply), retinal thickness (RT; reflecting vascular and neural tissue volume) and arterial blood were acquired. As a group, rVPD increased on Day 2 vs. Day 0 (p<0.001) and was inversely related to PaO2 (R2=0.45; p=0.006). By Day 9, rVPD recovered to baseline, but was significantly lower in males vs. females (p=0.007). RT was not different on Day 2 vs. Day 0 (p>0.99) but was reduced by Day 9 relative to Day 0 and Day 2 (p<0.001). RT changes relative to Day 0 were inversely related to changes in PaO2 on Day 2 (R2=0.6; p=0.001) and Day 9 (R2=0.4; p=0.02). RT did not differ between sexes. These data suggest differential time course and regulation of the retina during rapid ascent and prolonged exposure to high altitude and are the first to demonstrate sex-specific differences in rVPD at high altitude. The ability to assess intact microvasculature contiguous with the brain has widespread research and clinical applications.

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“…The retinal pigment epithelium with photoreceptor outer segment thickness showed significant thinning with increasing age and decreasing choroidal thickness. Both the retinal pigment epithelium with an outer photoreceptor segment and choroidal thickness showed a statistically significant negative correlation with age [ 57 ]. Our results did not reveal any age-related differences in the choroidal profiles of the dogs.…”

Section: Discussionmentioning

confidence: 99%

Morphological and Morphometric Analysis of Canine Choroidal Layers Using Spectral Domain Optical Coherence Tomography

Zwolska

Balicki

Balicka

2023

IJERPH

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The choroid, a multifunctional tissue, has been the focus of research interest for many scientists. Its morphology and morphometry facilitate an understanding of pathological processes within both the choroid and retina. This study aimed to determine the choroidal layer thicknesses in healthy, mixed-breed mesocephalic dogs, both male (M) and female (F), using spectral domain optical coherence tomography (SD-OCT) with radial, cross-sectional, and linear scans. The dogs were divided into two groups based on age: middle-aged (MA) and senior (SN). Thicknesses of choroidal layers, namely RPE–Bruch’s membrane–choriocapillaris complex (RPE-BmCc) with tapetum lucidum in the tapetal fundus, the medium-sized vessel layer (MSVL), and the large vessel layer with lamina suprachoroidea (LVLS), as well as whole choroidal thickness (WCT), were measured manually using the caliper function integrated into the OCT software. Measurement was performed dorsally and ventrally at a distance of 5000–6000 μm temporally and nasally at a distance of 4000–7000 μm to the optic disc on enhanced depth scans. The measurements were conducted temporally and nasally in both the tapetal (temporal tapetal: TempT, nasal tapetal: NasT) and nontapetal (temporal nontapetal: TempNT, nasal nontapetal: NasNT) fundus. The ratio of the MSVL thickness to the LVLS thickness for each region was calculated. In all examined dogs, the RPE-BmCc in the dorsal (D) region and MSVL in the Tt region were significantly thicker than those in the other regions. The MSVL was thinner in the ventral (V) region than in the D, TempT, TempNT and NasT regions. The MSVL was significantly thinner in the NasNT region than in the D region. LVLS thickness and WCT were significantly greater in the D and TempT regions than those in the other regions and significantly lesser in the V region than those in the other regions. The MSVL-to-LVLS thickness ratio did not differ between the age groups. Our results reveal that the choroidal thickness profile does not depend on age. Our findings can be used to document the emergence and development of various choroidal diseases in dogs in the future.

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Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes

Cited by 10 publications

References 32 publications

Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population

Inter- and Intra-individual Variations in Foveal Outer Nuclear Layer Thickness and Their Associations with Clinical Characteristics in a Healthy Chinese Population

Functional optical coherence tomography at altitude: retinal microvascular perfusion and retinal thickness at 3,800 meters

Morphological and Morphometric Analysis of Canine Choroidal Layers Using Spectral Domain Optical Coherence Tomography

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