Outer Plexiform Layer Elevations as a Marker for Prior Ocular Attacks in Patients With Behcet's Disease

Abstract

METHODS. Thirty-one consecutive patients (59 eyes) with Behcet's disease in remission and with available optical coherence tomography (OCT) images were included. The number of OPL bumps was counted using spectral-domain OCT images. The relationships between the number of bumps and visual acuity (VA), retinal thickness, choroidal thickness, disease duration, number of prior ocular attacks, and photoreceptor layer status (including external limiting membrane [ELM] and ellipsoid zone [EZ] continuity) were examined. RESULTS.Eyes with more severe EZ or ELM disruptions had lower VA, more ocular attacks, and thinner retinas. Additionally, EZ line and ELM line status were significantly correlated with the number of OPL elevations. Eyes with OPL elevations had poorer VA, longer disease duration, more ocular attacks, and thinner retinas than those without OPL elevations. Additionally, the number of OPL elevations was strongly correlated with the number of ocular attacks in eyes with a preserved photoreceptor layer (R ¼ 0.720, P < 0.0001).CONCLUSIONS. The number of OPL elevations was associated with the number of prior ocular attacks in eyes with preserved photoreceptor layers. Therefore, OPL elevations may be a marker of prior posterior ocular attacks, which is important when determining how best to manage Behcet's uveitis.

Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion

“…,), and which were also recently identified as being associated with Behcet's disease (Kido et al. ). Finally, in one patient with multiple bilateral resolved PAMM lesions, we observed the evolution of an acute hyperreflective lesion at the level of INL to a focal outer plexiform layer elevation similar to the evolution of the acute PAMM lesion (Nemiroff et al.…”

Quantitative measurements with optical coherence tomography angiography in Behçet uveitis

“…Similar to previous studies, we observed the localized RNFL defects identified by Oray et al, 21 which indicate the previous inflammatory episodes, were displayed as hypoperfused-nonperfused areas by OCTA. 12 OPL defects, which were reported by Kido et al 22 and were suggested as a marker for the previous uveitis episodes, were also examined. Hypoperfusionnonperfusion areas corresponding to these defects were determined with OCTA especially in DCP.…”

Old and New Challenges in Uveitis Associated with Behçet’s Disease

“…In contrast, OCT is a non-invasive tool used to visualize the fundus. Furthermore, OCT can provide useful markers of previous posterior ocular flares such as outer plexiform layer elevations associated with focal inner nuclear layer collapse (Figure 4) [27]; this could help with retrospective diagnosis in case of clinical suspicion. As described above, BD uveitis diagnosis is usually established in the presence of a coherent ocular clinical presentation and extraocular manifestations according to classification criteria.…”

“…In contrast, OCT is a non-invasive tool used to visualize the fundus. Furthermore, OCT can provide useful markers of previous posterior ocular flares such as outer plexiform layer elevations associated with focal inner nuclear layer collapse (Figure 4) [27]; this could help with retrospective diagnosis in case of clinical suspicion. A more recent technology, Enhanced Depth Imaging OCT (EDI-OCT) provides detailed and measurable images from the choroid.…”