Outer membrane proteins of Pseudomonas aeruginosa as vaccine candidates

Specht, Bernd-Ulrich von; Knapp, Bernhard; Hungerer, Klaus-Dieter; Lücking, Christian; Schmitt, Anja; Domdey, Horst

doi:10.1016/0168-1656(95)00161-1

Cited by 22 publications

(14 citation statements)

References 29 publications

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“…29,30,39,40 In this study, a strong response was also observed to OprF for all immunoglobulin isotypes in serum, which increased with disease progression and culture positive status. In BAL, the OprF specific antibody response was most prominent in the IgA isotype.…”

Section: Discussionmentioning

confidence: 70%

Mucosal and systemic antibody responses to potentialPseudomonas aeruginosavaccine protein antigens in young children with cystic fibrosis following colonization and infection

Moore

Kyd

Carzino

et al. 2013

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 70%

Mucosal and systemic antibody responses to potentialPseudomonas aeruginosavaccine protein antigens in young children with cystic fibrosis following colonization and infection

Moore

Kyd

Carzino

et al. 2013

Human Vaccines & Immunotherapeutics

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“…A logical hypothesis is that the immunogenicity of the OMF vaccine is due to the presence of outer membrane proteins and LPS, both of which have been shown to be important stimulators of the immune response against Gram-negative bacteria in fish as well as in mammals [11,[23][24][25][26][27][28]. Exactly why the OMF induced higher protection than the FKB is unclear.…”

Section: Discussionmentioning

confidence: 99%

The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

Rahman

Kuroda

Dijkstra

et al. 2002

Fish & Shellfish Immunology

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“…A number of strategies can be taken to interfering with bacterial adhesion [7], and the bacterial adhesion apparatus can form the basis of vaccines [61,62,63,64,65]. Passive immunization with antibodies against bacterial adhesion molecules have also been investigated [66, 67].…”

Section: Antiadhesive Strategiesmentioning

confidence: 99%

Stopping Bacterial Adhesion: A Novel Approach to Treating Infections

Bavington

Page²

2005

Respiration

108

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Adhesion and colonization are prerequisites for the establishment of bacterial pathogenesis. The prevention of adhesion is an attractive target for the development of new therapies in the prevention of infection. Bacteria have developed a multiplicity of adhesion mechanisms commonly targeting surface carbohydrate structures, but our ability to rationally design effective antiadhesives is critically affected by the limitations of our knowledge of the human ‘glycome’ and of the bacterial function in relation to it. The potential for the future development of carbohydrate-based antiadhesives has been demonstrated by a significant number of in vitro and in vivo studies. Such therapies will be particularly relevant for infections of mucosal surfaces where topical application or delivery is possible.

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Outer membrane proteins of Pseudomonas aeruginosa as vaccine candidates

Cited by 22 publications

References 29 publications

Mucosal and systemic antibody responses to potentialPseudomonas aeruginosavaccine protein antigens in young children with cystic fibrosis following colonization and infection

Mucosal and systemic antibody responses to potentialPseudomonas aeruginosavaccine protein antigens in young children with cystic fibrosis following colonization and infection

The outer membrane fraction of Flavobacterium psychrophilum induces protective immunity in rainbow trout and ayu

Stopping Bacterial Adhesion: A Novel Approach to Treating Infections

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