Outdoor particulate matter exposure and upper respiratory tract infections in children and adolescents: A systematic review and meta-analysis

Ziou, Myriam; Tham, Rachel; Wheeler, Amanda; Zosky, Graeme; Stephens, Nicola; Johnston, Fay

doi:10.1016/j.envres.2022.112969

Cited by 30 publications

(28 citation statements)

References 95 publications

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“…A narrative review was also performed for studies that were not included in the meta-analysis. 30 All data analyses were conducted in R software (version 4.1.2) using the package “meta”. A two-sided p < 0.05 was considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: First few hours of exposure matters to life

et al. 2022

eBioMedicine

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Section: Methodsmentioning

confidence: 99%

A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: First few hours of exposure matters to life

et al. 2022

eBioMedicine

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“…The upper respiratory tract infection (URTI) usually occurs with short, mild and self-limited process 2 . The high incidence of URTI is usually caused by viruses which can target the human respiratory tract, and cause different clinical manifestations, even lead to serious complications like acute respiratory distress syndrome (ARDS) [3][4][5][6] . The lower respiratory tract infection (LRTI) is mainly induced by virus, mycoplasma, chlamydia and bacteria, etc.…”

mentioning

confidence: 99%

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Zhang

Tao

Zou

et al. 2023

Sci Rep

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Respiratory tract infection is one of the most common reasons for both morbidity and mortality worldwide. High attention has been paid to the etiological tracing of respiratory tract infection since the advent of COVID-19. In this study, we aimed to evaluate the epidemiological features of pathogens in respiratory tract infection, especially during COVID-19 pandemic. A total of 7668 patients with respiratory tract infection who admitted to Qilu Hospital of Shandong University from March 2019 to Dec 2021 were retrospectively included. The respiratory tract specimens were detected using a commercial multiplex PCR-based panel assay for common respiratory pathogens including influenza A virus (Flu-A), influenza A virus H1N1 (H1N1), influenza A virus H3N2 (H3N2), influenza B virus (Flu-B), parainfluenza virus (PIV), respiratory syncytial virus (RSV), adenovirus (ADV), Boca virus (Boca), human Rhinovirus (HRV), Metapneumovirus (MPV), Coronavirus (COV), Mycoplasma pneumoniae (MP), and Chlamydia (Ch). The positive rates were compared using a chi-square test. Compared with 2019, the positive rate of pathogen detection during from January 2020 to December 2021 was significantly lower, especially the detection of Flu-A. The positive rate of respiratory pathogen strains was 40.18% during COVID-19 pandemic, and a total of 297 cases (4.69%) of mixed infection with two or more pathogens were detected. There was no statistical difference in the positive rate between male and female patients. However, the positive rates of infection were different among different age groups, with higher incidence of RSV in infancy and toddler group, and MP infection in children and teenager group. While, HRV was the most common pathogen in the adult patients. Moreover, Flu-A and Flu-B were higher in winter, and MP and RSV were higher in spring, autumn and winter. The pathogens such as ADV, BOCA, PIV, and COV were detected without significant seasonal distribution. In conclusion, respiratory pathogen infection rates may vary by age and season, regardless of gender. During the COVID-19 epidemic, blocking transmission routes could help reduce the incidence of respiratory tract infection. The current prevalence of respiratory tract infection pathogens is of great significance for clinical prevention, diagnosis and treatment.

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“…As one of the major components of air pollution, particulate matter 10 (PM 10, airbone particles < 10 μm)—which includes various heavy metals such as copper, lead, silicon, and aluminum—has recently become an important issue for population health outcomes. For example, it was the seventh largest risk factor for disability-adjusted-life years between 2000 and 2015 [ 1 – 3 ]. PM 10 also causes harmful health effects in various diseases, including cardiovascular disease, respiratory disease, and lung cancer and mortality [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression

et al. 2023

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Background Particulate matter10 (PM10) can induce airway inflammation and fibrosis. Recently, chitinase-1 has been shown to play key roles in inflammation and fibrosis. We aimed to investigate the effects of chitinase-1 inhibitor in PM10-treated murine mice models. Methods In female BALB/c mice, PM10 was intranasally administered six times over 3 weeks, and ovalbumin (OVA) was intraperitoneally injected and then intranasally administered. Chitinase-1 inhibitor (CPX) 6 times over 3 weeks or dexamethasone 3 times in the last week were intraperitoneally administered. Two days after the last challenges, mice were euthanized. Messenger RNA sequencing using lung homogenates was conducted to evaluate signaling pathways. Results PM10 and/or OVA-induced airway inflammation and fibrosis murine models were established. CPX and dexamethasone ameliorated PM10 or PM10/OVA-induced airway hyper-responsiveness, airway inflammation, and fibrosis. CPX and dexamethasone also reduced levels of various inflammatory markers in lung homogenates. PM10 and OVA also induced changes in mRNA expression across an extreme range of genes. CPX and dexamethasone decreased levels of mRNA expression especially associated with inflammation and immune regulation. They also significantly regulated asthma and asthma-related pathways, including the JACK-STAT signaling pathway. Conclusions Chitinase-1 suppression by CPX can regulate PM10- and OVA-induced and aggravated airway inflammation and fibrosis via an asthma-related signaling pathway.

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Outdoor particulate matter exposure and upper respiratory tract infections in children and adolescents: A systematic review and meta-analysis

Cited by 30 publications

References 95 publications

A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: First few hours of exposure matters to life

A systematic review and meta-analysis of intraday effects of ambient air pollution and temperature on cardiorespiratory morbidities: First few hours of exposure matters to life

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression

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