Outcomes used in trials regarding the prevention and treatment of orthodontically induced white spot lesions: A scoping review

Wang, Yunlei; Qin, Danchen; Feng, Guo; Levey, Colin; Huang, Greg J.; Ngan, Peter; Hua, Fang; He, Hong

doi:10.1016/j.ajodo.2021.04.018

Cited by 11 publications

(7 citation statements)

References 87 publications

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“…The lack of relevance and consistency among outcomes used in dental trials has been well documented in previous systematic reviews and methodological studies. 3 As a result, in quite a lot areas of dentistry, despite the fact that a large number of relevant trials exist, it has been difficult for systematic reviewers to arrive at a clear, consistent conclusion and for clinicians to practice evidence-based care. To reduce this wasteful heterogeneity, a COS is needed to standardize the outcome selection of trials in each area, and thereby facilitate the synthesis and translation of relevant evidence.…”

Section: Standardization Of Dpro-related Methodologymentioning

confidence: 99%

“…Patients' needs and preferences have long been one of the three essential elements of evidence-based dentistry (EBD). 1 However, in most areas of dental research, the voices of dental patients have been overlooked, 2,3 resulting in findings with limited value for dental practice and a high level of avoidable research waste. 4 Previous studies have shown that the appropriate use of dental patient-reported outcomes (dPROs) --reports of patients' oral health condition that come directly from the patients, 5 is essential for dental research to fully reflect the impact of oral diseases or oral health care on patients 6,7 and to directly support dentist-patient communication.…”

Section: Introductionmentioning

confidence: 99%

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Dental Patient-Reported Outcomes Update 2021

Hua

2022

Journal of Evidence-Based Dental Practice

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Section: Standardization Of Dpro-related Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dental Patient-Reported Outcomes Update 2021

Hua

2022

Journal of Evidence-Based Dental Practice

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“…Within the studies that refer to white spot lesions in patients with braces, there is a large number that have tried to know if there is any preventive therapy that provides better results than others. Wang et al 22 and Perrini et al 23 show that under different preventive therapies, there is a difference in the incidence of these kind caries. Humin et al 20 in their systematic review sustain that there is a difference in the incidence of white spot lesions for groups that use different remineralizing agents, adjusting their results for sex, ethnicity and age.…”

Section: Prevention Of White Spot Lesions In People With Bracesmentioning

confidence: 99%

Dental caries during orthodontic treatment: a review of the literature

Schulz¹,

Yáñez²

2022

MOJOR

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Background: Dental caries is a dynamic, non-transmissible and multifactorial disease caused by the acid generated by bacterial plaque. It is a very common pathology in the population, which in turn presents various risk factors that are often difficult to identify. Objective: The objective of this research is to provide a broader view of dental caries during orthodontic treatment, not as specific clinical signs, but in a more comprehensive way, including all the associated factors involved. Methods: A database search was conducted to obtain appropriate articles. The following databases were consulted: Pubmed, Medline, and The Cochrane Library, from 2010 to 2022. Results: The results showed that there is an association between caries disease and the use of orthodontics, where the risk of presenting caries lesions increases in those who use orthodontic appliances and also have a higher risk of developing white spot lesions than those who do not use orthodontic appliances. It is also noted that the preventive use of different remineralizing agents could be useful in reducing the incidence of white spot lesions. Conclusión: We can conclude that there is an association between the use of orthodontics and the presence of dental caries, with the white spot being the most studied sign of this. More studies are required with a methodology focused on caries as a complex and multifactorial phenomenon.

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“…White spot lesions (WSLs) are the frequently diagnosed side-effect associated with microbial colonization around brackets in fixed orthodontics ( Maxfield et al, 2012 ; Wang et al, 2021 ). Despite many attempts focusing on the prevention of demineralization, the prevalence of WSLs remains as high as 61% after debonding ( Øgaard et al, 2001 ; Sundararaj et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Influence of resin modified glass ionomer cement incorporating protein-repellent and antimicrobial agents on supragingival microbiome around brackets: an in-vivo split-mouth 3-month study

Yang

et al. 2023

PeerJ

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Objective To explore the influence of resin modified glass ionomer cement (RMGIC) adhesives containing protein-repellent and quaternary ammonium salt agents on supragingival microbiome, enamel and gingival health around brackets. Materials and Methods Ten patients (21.4 ± 3.5 years) about to receive fixed orthodontics were enrolled in this study. Unilateral upper teeth bonded with RMGIC incorporating 2-Methacryloyloxyethyl phosphorylcholine (MPC) and Dimethylaminohexadecyl methacrylate (DMAHDM) were regarded as experimental group (RMD), while contralateral upper teeth bonded with RMGIC were control group (RMGIC), using a split-mouth design. Supragingival plaque was collected from both groups before treatment (T0), and at 1 month (T1) and 3 months (T2) of treatment. High-throughput sequencing was performed targeting v3–v4 of 16S rRNA gene. Streptococcus mutans and Fusobacterium nucleatum quantification was done by qPCR analysis. Bracket failures, enamel decalcification index (EDI), DIAGNODent scores (Dd), plaque index (PI) and gingival index (GI) were monitored at indicated time points. Results Within 3 months, alpha and beta diversity of supragingival plaque had no difference between RMGIC and RMD groups. From T0 to T2, the relative abundance of Streptococcus depleted in RMD but remained steady in RMGIC group. Streptococcus, Prevotella, and Fusobacterium became depleted in RMD, Haemophilus and Capnocytophaga became depleted in RMGIC group but Prevotella enriched. Quantification of Fusbacterium nucleatum and Streptococcus mutans showed significant difference between RMGIC and RMD groups at T2. Teeth bonded with RMD had significant lower plaque index (PI) and DIAGNODent (Dd) score at T2, compared with teeth bonded with RMGIC (p < 0.05). No difference in bracket failure rate was examined between both groups (p > 0.05). Conclusion By incorporating MPC and DMAHDM into RMGIC, the material could affect the supragingival microbial composition, inhibit the progress of plaque accumulation as well as the key pathogens S. mutans and F. nucleatum in the early stage of orthodontic treatment.

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Outcomes used in trials regarding the prevention and treatment of orthodontically induced white spot lesions: A scoping review

Cited by 11 publications

References 87 publications

Dental Patient-Reported Outcomes Update 2021

Dental Patient-Reported Outcomes Update 2021

Dental caries during orthodontic treatment: a review of the literature

Influence of resin modified glass ionomer cement incorporating protein-repellent and antimicrobial agents on supragingival microbiome around brackets: an in-vivo split-mouth 3-month study

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