Outcomes of ultrasound‐guided percutaneous argon‐helium cryoablation of hepatocellular carcinoma

Yang, Yongping; Wang, Chunping; Lu, Yinying; Bai, Wenlin; An, Lihui; Qu, Jing; Gao, Xudong; Chen, Yan; Zhou, Lin; Yu, Wenli; Feng, Yukuan; Zhang, Minna; Chang, Xiujuan; Lv, Jiyun

doi:10.1007/s00534-011-0490-6

Cited by 57 publications

(50 citation statements)

References 22 publications

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“…We therefore sought to find more effective treatment strategies. Since argon-helium cryosurgery system (AHCS) could effectively kill tumor cells [10], in this study, we further explored the anti-tumor effect by combining AHCS with TACE.…”

Section: Introductionmentioning

confidence: 99%

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

Huang¹,

Wang²,

Huang³

2015

Cell Biochem Biophys

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Hepatocellular carcinoma (HCC) is one of the most aggressive tumors in humans. T lymphocytes and natural killer (NK) cells are the body's first line of defense to prevent tumor cell growth. Previous studies have demonstrated that transcatheter arterial chemoembolization (TACE) combined with argon-helium cryosurgery system (AHCS) can effectively treat liver cancer. However, the mechanism of the treatment is unclear yet. In the current study, we investigated the effects of TACE combined with AHCS on the changes of T cell subsets and NK cells in peripheral blood of HCC. Our data show that alpha-fetoprotein (AFP) levels in peripheral blood were significantly up-regulated in HCC patients before treatment when compared with healthy people and reduced after TACE combined with AHCS treatment (P < 0.01). In addition, we found that CD4+ cells and NK cells decreased (P < 0.05) and CD8+ cells increased (P < 0.05) in HCC patients when compared with healthy people. After treatment, the CD4+ cells, CD4+/CD8+ ratio, and NK cells were dramatically increased in HCC patients (P < 0.05). In contrast, CD8+ cells were significantly decreased (P < 0.05). TACE combined with AHCS treatment significantly prolonged 1-year survival rate of HCC patients and did not show significant side effects. Taken together, our data indicate that TACE combined with AHCS treatment improves patients' immune system. It is a feasible and effective therapeutic method for HCC patients.

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Section: Introductionmentioning

confidence: 99%

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

Huang¹,

Wang²,

Huang³

2015

Cell Biochem Biophys

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“…Although some early review articles reported insufficient data to support or refute cryotherapy for HCC [90], many recent studies have shown that image-guided percutaneous cryoablation is safe and effective for treating HCC [82,83,84,91,92]. A single meta-analysis performed by Huang et al [93] investigated the role of cryoablation in comparison to RFA in treating unresectable HCC and showed an advantage for RFA over cryotherapy in terms of complication rates (OR 2.80; 95% CI, 1.54-5.09) and local tumor recurrence (OR 1.96; 95% CI, 1.12-3.42).…”

Section: Local Ablative Therapymentioning

confidence: 99%

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Shi

Zhai

2016

Gastrointest Tumors

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Background: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most common cause of cancer-related deaths. Hepatic resection and liver transplantation are considered to be the preferred treatment for HCC. However, as novel therapeutic options such as image-guided locoregional therapies have emerged and been refined, the manner in which HCC is treated has changed dramatically compared with what it was considered just 2 decades earlier. Summary: This study reviews the current results of various image-guided locoregional therapies for treating HCC, especially focusing on thermal ablative and transarterial techniques. Key Message: Advances in image-guided locoregional therapies, including local ablative therapy and transarterial therapy, have led to a major breakthrough in the management of HCC. Both survival rates and cure rates of patients with HCC have improved markedly since the introduction of these techniques. Practical Implications: Radiofrequency ablation is currently considered as an alternative to surgical resection for patients with early-stage HCC. A newer technique of ablation such as microwave ablation is increasingly being used, especially for large HCC. Transarterial chemoembolization has become a standard care for asymptomatic patients with multinodular tumors in intermediate-stage disease, and transarterial radioembolization has become the method of choice in HCC cases with portal vein thrombosis. Moreover, combination treatment modalities, such as thermal-based ablation combined with transarterial chemoembolization or ¹²⁵I seed implant brachytherapy, may further broaden their clinical indications for HCC. Moreover, use of localized radiation in combination with thermal ablation has been reported to improve tumor control and long-term survival.

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“…Cryoshock is a significant systemic adverse effect of cryoablation, which has been reported to occur in 1-2 % of all hepatic cryoablation [41,42]. We did not experience any case of cryoshock.…”

Section: Discussionmentioning

confidence: 76%

Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy

Kim

Won

Kim

et al. 2016

Cardiovasc Intervent Radiol

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Outcomes of ultrasound‐guided percutaneous argon‐helium cryoablation of hepatocellular carcinoma

Cited by 57 publications

References 22 publications

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma

Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy

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