Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA

Susceptibility Pattern of Microorganisms Isolated by Percutaneous Needle Biopsy in Nonbacteremic Pyogenic Vertebral Osteomyelitis

“…The prevalence of multidrug-resistant bacteria was low in our population. In fact, only one strain of S. aureus was methicillin resistant, which contrasts with previous studies, in which MRSA has been reported in 19.2 to 53.3% of cases of PVO (20)(21)(22)(23)(24)(25)(26). Similarly, we did not isolate any extended-spectrum ␤-lactamase (ESBL)-producing Enterobacteriaceae, which is inconsistent with recent data showing an increase in resistant strains of Enterobacteriaceae.…”

Pyogenic Vertebral Osteomyelitis: Clinical Features, Diagnosis, and Treatment

“…Among the S. aureus , the prevalence of methicillin-resistant Staphylococcus aureus ( MRSA) seems to be increasing recently compared to previous data, up to 40%–57.1%6,61,67,73). Male sex, multiple comorbidities and previous non-spine surgery were significant risk factors for PVO due to MRSA as compared to methicillin-sensitive Staphylococcus aureus (MSSA)37).…”

“…No controlled trial data is available on the optimal treatment duration, but usually 4–6 weeks81,98), up to 3 months61,77) are recommended. In the presence of undrained abscess or spinal prosthesis, longer duration of antibiotic treatment is desired49,99,100).…”

Clinical Impact of SPECT/CT With In-111 Biotin on the Management of Patients With Suspected Spine Infection

“…Drainage of the abscess is performed and specific antibiotics are used if infection is limited to the paravertebral soft tissues, while other antibiotics are reserved when bone infection is present. 30 The choice of antibiotics is, of course, based on the preferences of the clinician and resistance testing but usually it is different according to the site of infection. 31 It should also be noted that early and correct localization of infection is important for Clinical Impact of In-111 Biotin SPECT/CT prognostic purposes, as the absence of neurologic symptoms is associated with a better outcome.…”