Outcomes of standard dose EC-MPS with low exposure to CsA in DCD renal transplantation recipients with DGF

Abstract

These results show that low expose CsA with standard dosing of EC-MPS and thymoglobulin was efficacious, safe and well-tolerated in DCD renal transplant recipients with DGF in China. Furthermore, stable and adequate MPA exposure helped to reduce the dose of and exposure to CsA. Thus, this may lead to less-induced nephrotoxicity and better renal function recovery.

Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation

“…As a result of the extensive application of MPA and CNIs, many studies have demonstrated that CNI exposure can cause acute and chronic nephrotoxicity; thus, low exposure to CNIs has been advocated in the recent years to further improve transplant outcomes, particularly in ECD kidneys. [ 13 14 15 16 17 ] However, many studies have shown that lower Tac C 0 levels during the 1 st week,[ 18 ] during the 1 st month,[ 19 ] after 3 months,[ 20 ] and Tac C 0 of <4 ng/ml[ 13 ] or <7 ng/ml[ 21 ] posttransplant were significantly correlated with the subsequent higher BPAR rates. Therefore, we decided to use the cut-point <4.0 versus ≥4.0 ng/ml and <7.0 versus ≥7.0 ng/ml to analyze the association between Tac C 0 and BPAR risk during the first 12 months after transplantation.…”

Short-Term Intensified Dosage Regimen of Mycophenolic Acid is Associated with Less Acute Rejection in Kidney Transplantation from Donation after Circulatory Death

“…Previous studies showed that MPA exposure decreased in patients with DGF [17,18]. Owing to nephrotoxicity, high exposure to calcineurin inhibitors (cyclosporine or tacrolimus) was restricted in patients with DGF [19][20][21]. An increased early exposure to MPA might aid in reducing the need for high exposure to calcineurin inhibitors.…”

Beneficial Effect of Moderately Increasing Hypothermic Machine Perfusion Pressure on Donor after Cardiac Death Renal Transplantation

“…Thymoglobulin or rabbit antihuman thymocyte immunoglobulin was administered for 5–10 days in patients with steroid-resistant rejection or early high-grade rejection. [ 23 24 ] Rituxan ® (200 mg) was administered for one or two times in patients with antibody-mediated rejection (AMR), plus plasmapheresis and intravenous immunoglobulin.…”