Outcomes of Screening Mammography by Frequency, Breast Density, and Postmenopausal Hormone Therapy

Kerlikowske, Karla; Zhu, Weiwei; Hubbard, Rebecca A.; Geller, Berta M.; Dittus, Kim; Braithwaite, Dejana; Wernli, Karen J.; Miglioretti, Diana L.; O’Meara, Ellen S.

doi:10.1001/jamainternmed.2013.307

Cited by 179 publications

(149 citation statements)

References 42 publications

(76 reference statements)

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“…4,[94][95][96][97][98][99][100] Women with high breast density have been reported to have a four to six times increased risk of developing breast cancer compared with those with low breast density, 95,[101][102][103][104][105] and high breast density has also been linked to an increased risk of cancers not detected at screening, 4,8,96,106,107 larger tumour size [108][109][110] and positive lymph nodes. 109,[111][112][113] The underlying cause of these links are thought to be numerous, and early studies hypothesised that a significant reason for an increase in breast cancer incidence with higher density breasts was as a result of a 'masking bias' that made mammographic screening less sensitive to cancer detection. 96,101 Later studies, however, have shown that there is increased risk for at least 7-10 years following a screening examination, indicating that 'masking bias' is only one of the mechanisms linking breast density to an increased cancer risk.…”

Section: Introductionmentioning

confidence: 99%

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Gilbert

Tucker

Gillan

et al. 2015

Health Technology Assessment

154

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The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme -a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 09/22/182. The contractual start date was in December 2010. The draft report began editorial review in February 2014 and was accepted for publication in August 2014. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report. Background: Digital breast tomosynthesis (DBT) is a three-dimensional mammography technique with the potential to improve accuracy by improving differentiation between malignant and non-malignant lesions.

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Section: Introductionmentioning

confidence: 99%

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Gilbert

Tucker

Gillan

et al. 2015

Health Technology Assessment

154

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“…36,37 Women with lower familial risk, no genetic markers and lower mammographic density could benefit from less frequent imaging and no additional imaging outside the standard mammographic screening program. 38,39 Additional imaging and/or less/more frequent screening obviously is associated with higher costs and potential for increase false-…”

mentioning

confidence: 99%

Impact of errors in recorded compressed breast thickness measurements on volumetric density classification using volpara v1.5.0 software

Waade

Highnam²,

Hauge

et al. 2016

Medical Physics

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2 AbstractPurpose: Mammographic density has been demonstrated to predict breast cancer risk. It has been proposed that it could be used for stratifying screening pathways and recommending 35 additional imaging. Volumetric density tools use the recorded compressed breast thickness (CBT) of the breast measured at the x-ray unit in their calculation, however the accuracy of the recorded thickness can vary. The aim of this study was to investigate whether inaccuracies in recorded CBT impact upon volumetric density classification and to examine whether the current quality control (QC) standard is sufficient for assessing mammographic density. 40Methods: Raw data from 52 digital screening mammograms were included in the study. For each image, the clinically recorded CBT was artificially increased and decreased to simulate measurement error. Increments of 1mm were used up to ±15% error of recorded CBT was achieved. New images were created for each 1mm step in thickness resulting in a total of 974 images which then had Volpara Density Grade (VDG) and volumetric density percentage 45 assigned. Results: A change in VDG was recorded in 38.5% (n= 20) of mammograms when applying ±15% error to the recorded CBT and 11.5 % (n= 6) were within the QC standard prescribed error of ±5mm. Conclusion:The current QC standard of ±5mm error in recorded CBT creates the potential 50 for error in mammographic density measurement. This may lead to inaccurate classification of mammographic density. The current QC standard for assessing mammographic density should be reconsidered.

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“…The results of this comparison might also be influenced by breast density, which is associated with increased breast cancer incidence, also in BRCA1/2 mutation carriers, 36 and decreased sensitivity of mammography. 37 In conclusion, the majority of BRCA1/2 mutation carriers are still at risk for breast cancer after the age of 60. If life expectancy is good, annual mammography screening of BRCA1/2 mutation carriers !60 should be considered over biennial screening.…”

Section: 31mentioning

confidence: 94%

Relevance and efficacy of breast cancer screening inBRCA1andBRCA2mutation carriers above 60 years: A national cohort study

et al. 2014

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Annual MRI and mammography is recommended for BRCA1/2 mutation carriers to reduce breast cancer mortality. Less intensive screening is advised !60 years, although effectiveness is unknown. We identified BRCA1/2 mutation carriers without bilateral mastectomy before age 60 to determine for whom screening !60 is relevant, in the Rotterdam Family Cancer Clinic and HEBON: a nationwide prospective cohort study. Furthermore, we compared tumour stage at breast cancer diagnosis between different screening strategies in BRCA1/2 mutation carriers !60. Tumours >2 cm, positive lymph nodes, or distant metastases at detection were defined as "unfavourable." Of 548 BRCA1/2 mutation carriers !60 years in 2012, 395 (72%) did not have bilateral mastectomy before the age of 60. Of these 395, 224 (57%) had a history of breast or other invasive carcinoma. In 136 BRCA1/2 mutation carriers, we compared 148 breast cancers (including interval cancers) detected !60, of which 84 (57%) were first breast cancers. With biennial mammography 53% (30/57) of carcinomas were detected in unfavourable stage, compared to 21% (12/56) with annual mammography (adjusted odds ratio: 4Á07, 95% confidence interval [1.79-9.28], p 5 0.001). With biennial screening 40% of breast cancers were interval cancers, compared to 20% with annual screening (p 5 0.016). Results remained significant for BRCA1 and BRCA2 mutation carriers, and first breast cancers separately. Over 70% of 60-year old BRCA1/2 mutation carriers remain at risk for breast cancer, of which half has prior cancers. When life expectancy is good, continuation of annual breast cancer screening of BRCA1/2 mutation carriers !60 is worthwhile. Epidemiology

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Outcomes of Screening Mammography by Frequency, Breast Density, and Postmenopausal Hormone Therapy

Cited by 179 publications

References 42 publications

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Impact of errors in recorded compressed breast thickness measurements on volumetric density classification using volpara v1.5.0 software

Relevance and efficacy of breast cancer screening inBRCA1andBRCA2mutation carriers above 60 years: A national cohort study

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