Outcomes of Prosthetic Reconstruction of Irradiated and Nonirradiated Breasts with Fat Grafting

Abstract

Therapeutic, III.

Meta-analysis of the oncological safety of autologous fat transfer after breast cancer

“…Finally, data from all non-overlapping populations in case series 17 -19,21,24,27,28,30,33,35,36,38,43,46,50,52-54,56,63,64,67,72,74 as well as AFT treatment arms of cohort studies (References 26,31,32,[39][40][41][42]45,47,49,61,68,70,71 and T. Krastev et al,unpublished results) were pooled to provide an estimate of the combined incidence rate of LRR after exposure to AFT (period B). The raw incidence rate for all patients was 0⋅73 (0⋅56 to 0⋅94) per cent per year ( Fig.…”

“…Komorowska-Timek et al 41 Kim et al 40 Khan et al 39 Kaoutzanis et al 38 Ihrai et al 36 Hoppe et al 35 Helme et al 33 Gale et al 32 Fertsch et al 31 Doren et al 30 Delaporte et al 28 Constantini et al 27 Cohen et al 26 Brown et al 24 Bonomi et al 21 Beck et al 19 Bayti et al 18 Amar The meta-analysis was performed using the metafor package 16 of RStudio software, version 1.0.136 (R Foundation for Statistical Computing, Vienna, Austria). Summary measures (incidence rates) were pooled in a Poisson-normal random-effects model and presented as forest plots.…”

“…Komorowska-Timek et al 41 Kim et al 40 Kaoutzanis et al 38 Ihrai et al 36 Hoppe et al 35 Gale et al 32 Fertsch et al 31 Doren et al 30 Cohen et al 26 Brown et al 24 Bonomi et al 21 Bayti Silva-Vergara et al 70 Seth et al 68 Petit et al 58 Masia et al 47 Kronowitz et al 42…”

“…Komorowska-Timek et al 41 Kaoutzanis et al 38 Gale et al 32 Fertsch et al 31 Biazus et al 20 8 Forest plot showing raw incidence rate of locoregional recurrence (LRR) in period B in case series and the autologous fat transfer (AFT) groups in cohort studies, according to histology of carcinoma. Incidence rates are shown with 95 per cent confidence intervals.…”

International multidisciplinary expert panel consensus on breast reconstruction and radiotherapy

“…The generic reference to ‘breast reconstruction’ was intended to capture all articles addressing the type and timing of breast reconstruction. Two authors independently reviewed abstracts of all studies published between 1985 and 2014, and the full texts of those studies published in 2015–2017. Levels of clinical evidence (LoE) were evaluated for each publication and scored from I to V by employing Oxford criteria.…”