Outcomes of Preterm Labor and Preterm Births: A Retrospective Cross-Sectional Analytical Study in a Nigerian Single Center Population

Umeigbo, Blessing C; Modebe, I; Iloghalu, Ifeoma C.; Eleje, George Uchenna; Okoro, Chukwuemeka Chukwubuikem; Umeononihu, Osita Samuel; Emeka, Ekene Agatha

doi:10.26502/ogr031

Cited by 9 publications

(6 citation statements)

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“…The World Health Organization (WHO) has defined preterm birth as any delivery occurring prior to gestational age of 37 finished weeks or fewer than 259 days from the first day of the last menstrual period of a woman (Blencowe 2013;Eke 2019a;Eleje 2017;Umeigbo 2020;WHO 1977). In 2012, no fewer than 450,000 per 4 million newborns were a ected by preterm birth, accounting for one in every nine infants born in the United States (CDC 2014).…”

Section: Description Of the Conditionmentioning

confidence: 99%

“…For decades, births at preterm gestation remain the principal cause of both mortality and morbidity during a period immediately before and a er birth (Castanon 2015;Saccone 2015b;Slager 2012). Preterm birth has generated a substantial public health burden and it remains an essential element implicated as a cause of global loss of potential human resources in the surviving newborns (Umeigbo 2020). Of all direct causes of deaths in the neonatal period, preterm births constitute the greatest share, contributing up to 35% of more than 3 million annual deaths worldwide.…”

Section: Description Of the Conditionmentioning

confidence: 99%

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Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies

Eleje

Eke

Ikechebelu

et al. 2020

Cochrane Database of Systematic Reviews

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Section: Description Of the Conditionmentioning

confidence: 99%

Section: Description Of the Conditionmentioning

confidence: 99%

Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies

Eleje

Eke

Ikechebelu

et al. 2020

Cochrane Database of Systematic Reviews

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“…11 Another study by Umeigbo et al in 2015 in Nigeria showed that 45.3% birth in between 32-36 weeks, 41.7% between 28-30 week, and only 13% in between 24-27 week of gestation. 12 Thus it was concluded that maximum number of preterm birth was after 32 week of gestation. Among the risk factors in previous pregnancy previous history of abortion was found in maximum patient (29.5%), followed by 27.6% seen in previous preterm delivery history.…”

Section: Discussionmentioning

confidence: 99%

An observational study of aetiology of preterm labour in a tertiary health care centre

Shaheen¹,

Chauhan²,

Alka³

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Preterm labor and delivery are very challenging obstetric complications encountered by obstetrician as preterm births are the major cause of perinatal and neonatal morbidity and mortality.Methods: An observational study was conducted in the Department of Obstetrics and Gynaecology, Himalayan Institute of Medical Sciences (HIMS), Jollygrant, Dehradun, over a period of one year in which 105 preterm pregnant were observed and risk factors associated with preterm labour were evaluated. Results: Preterm labour was more common in multigravida as compared to primigravida. Maximum (58.10%) number of preterm birth occurred after 32 weeks of gestation. In previous history of pregnancy most important history was previous history of abortion than previous history of preterm labour. Previous one history of abortion was more commonly associated than previous history of 2 or more than 2 abortions. Preterm prelabour rupture of membranes was most important risk factor associated with preterm labour and delivery followed by UTI, than PIH and anemia being the 4th important reason.Conclusions: Thus we concluded that various risk factors that lead to preterm labor are identifiable and mostly are modifiable. Therefore, preconceptional counseling has a great role to play in bringing down the incidence of preterm labour.

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“…Preterm birth continues to be the principal reason for global perinatal near-misses and mortality. [7][8][9][10] This is also responsible for up to 70% of mortalities during the neonatal period and long-lasting neural problems. [8][9][10][11] Preterm birth contributes to 5-13% of all deliveries.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

Eleje,

Nwagha,

Ezebialu

et al. 2023

Explor Res Hypothesis Med

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Background and objectives: No previous study has been conducted in Nigeria on the role of neutrophil elastase in predicting preterm birth. The present study aimed to determine the role of the neutrophil elastase test in predicting birth in women with preterm labor. Methods: The present prospective cohort study recruited 83 pregnant women with preterm labor between 28 and 36 +6 weeks of gestation, and followed up these subjects for 14 days. The controls comprised 85 pregnant women without preterm labor. The cervicovaginal fluid was collected and tested using the neutrophil elastase test. Then, the sensitivity, specificity, and positive and negative predictive parameters were determined. Afterward, the data were scrutinized using the SPSS arithmetic software (Sort23). Results: Among the 168 pregnant women analyzed in the present study, 83 pregnant women were assigned to the preterm labor group, and 85 pregnant women were assigned to the control group. Furthermore, among the 83 pregnant women in the preterm labor group, 11 women had spontaneous preterm delivery, leading to a spontaneous preterm birth proportion of 13.3%. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the neutrophil elastase test within 14 days post-enrollment were 93.8%, 61.2%, 36.6%, 97.6%, and 67.5%, respectively, for the general population, and 87.5%, 66.7%, 35.0%, 96.3%, and 70.2%, respectively, for subjects at <35 weeks of gestation. The positive and negative likelihood ratios for preterm birth prediction were 2.62 and 0.19, respectively. Conclusion: The neutrophil elastase test exhibited high predictive accuracy in pregnant women with preterm labor, when compared to the controls, based on the sensitivity and negative predictive value, but this had poor positive predictive values. The neutrophil elastase test may be used as a screening test, but not as a potential predictive test, in the routine clinical setting.

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Outcomes of Preterm Labor and Preterm Births: A Retrospective Cross-Sectional Analytical Study in a Nigerian Single Center Population

Cited by 9 publications

References 0 publications

Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies

Cervical stitch (cerclage) in combination with other treatments for preventing spontaneous preterm birth in singleton pregnancies

An observational study of aetiology of preterm labour in a tertiary health care centre

Neutrophil Elastase as a Predictor of Delivery in Pregnant Women with Preterm Labour

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