Abstract:Background: Compared with those born at term gestation, infants with complex congenital heart defects (CCHD) who were delivered before 37 weeks gestational age and received neonatal open-heart surgery (OHS) have poorer neurodevelopmental outcomes in early childhood. We aimed to describe the growth, disability, functional, and neurodevelopmental outcomes in early childhood of preterm infants with CCHD after neonatal OHS. Prediction models were evaluated at various timepoints during hospitalization which could b… Show more
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, 12–31 PRISMA diagram (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 PRISMA diagram (Figure 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] PRISMA diagram (Figure 1). 1 and 2) Setting: All included studies came from high-income countries.…”
Aim
Congenital heart disease (CHD) is one of the most common birth defects affecting around 1:100 infants. In this systematic review, we aimed to determine impact of growth on neurodevelopmental outcomes of infants with CHD.
Methods
Studies that reported association of growth with developmental outcomes in infants with CHD who had surgery, were included. The search strategy was prospectively registered. Relevant studies were identified by electronic searches. The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched from their earliest date to February 2022.
Results
Twenty studies met inclusion criteria. Choice of growth measures, developmental assessment tools and timing of assessment varied widely precluding conduct of a meta‐analysis. Seventeen studies reported on infants who had cardio‐pulmonary bypass. Birth weight was reported in thirteen studies and was associated with adverse outcome in nine. Head circumference at birth and later predicted developmental outcomes in five. Impaired postnatal growth was associated with adverse developmental outcome in seven studies.
Conclusion
Growth in infants with congenital heart disease, specifically single ventricle physiology can predict adverse neurodevelopmental outcome. Included studies showed significant clinical heterogeneity. Uniformity should be agreed by various data registries with routine prospective collection of growth and developmental data.
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, 12–31 PRISMA diagram (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 PRISMA diagram (Figure 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…10 333 studies were not relevant. Full text of 51 studies was sought and 20 were included in the final review, [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] PRISMA diagram (Figure 1). 1 and 2) Setting: All included studies came from high-income countries.…”
Aim
Congenital heart disease (CHD) is one of the most common birth defects affecting around 1:100 infants. In this systematic review, we aimed to determine impact of growth on neurodevelopmental outcomes of infants with CHD.
Methods
Studies that reported association of growth with developmental outcomes in infants with CHD who had surgery, were included. The search strategy was prospectively registered. Relevant studies were identified by electronic searches. The Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE were searched from their earliest date to February 2022.
Results
Twenty studies met inclusion criteria. Choice of growth measures, developmental assessment tools and timing of assessment varied widely precluding conduct of a meta‐analysis. Seventeen studies reported on infants who had cardio‐pulmonary bypass. Birth weight was reported in thirteen studies and was associated with adverse outcome in nine. Head circumference at birth and later predicted developmental outcomes in five. Impaired postnatal growth was associated with adverse developmental outcome in seven studies.
Conclusion
Growth in infants with congenital heart disease, specifically single ventricle physiology can predict adverse neurodevelopmental outcome. Included studies showed significant clinical heterogeneity. Uniformity should be agreed by various data registries with routine prospective collection of growth and developmental data.
Advances in cardiac surgical techniques taking place over the past 50 years have resulted in the vast majority of children born with congenital cardiac malformations now surviving into adulthood. As the focus shifts from survival to the functional outcomes of our patients, it is increasingly being recognized that a significant proportion of patients undergoing infant cardiac repair experience adverse neurodevelopmental (ND) outcomes. The etiology of abnormal brain development in the setting of congenital heart disease is poorly understood, complex, and likely multifactorial. Furthermore, the efficacy of therapies available for the learning disabilities, attention deficit, and hyperactivity disorders and other ND deficits complicating congenital heart disease is currently uncertain. This situation presents a challenge for prenatal counseling as current antenatal testing does not usually provide prognostic information regarding the likely ND trajectories of individual patients. However, we believe it is important for parents to be informed about potential issues with child development when a new diagnosis of congenital heart disease is disclosed. Parents deserve a comprehensive and thoughtful approach to this subject, which conveys the uncertainties involved in predicting the severity of any developmental disorders encountered, while emphasizing the improvements in outcomes that have already been achieved in infants with congenital heart disease.A balanced approach to counseling should also discuss what local arrangements are in place for ND follow-up. This review presents an up-to-date overview of ND outcomes in patients with congenital heart disease, providing possible approaches to communicating this information to parents during prenatal counseling in a sensitive and accurate manner.
Key pointsWhat is already known about this topic? � The heart is the organ most commonly affected by birth defects.� Neurodevelopmental (ND) disorders frequently affect children with congenital heart disease, with those with genetic syndromes and single ventricle hearts most severely affected, although even mild forms of heart disease confer some risk.
What does this review add?� This review summarizes current knowledge regarding the prevalence, etiology, and risk factors for ND disorders in patients with congenital heart disease across the lifespan.
“… 22 The incidence of NEC in premature infants with CHD is actually higher than those with idiopathic NEC, presumably because these infants not only have the classic risk factors of preterm babies but also the hemodynamic changes observed in CHD. 4 , 20 , 23 – 25 …”
Section: Histopathological Characteristics Of Nec In Infants With Chdmentioning
Necrotizing enterocolitis (NEC) is a relatively rare but devastating entity associated classically with the preterm cohort in the neonatal intensive care unit. Preterm and term babies with congenital heart disease are at risk of a number of comorbidities because of the hemodynamic derangements due to a structurally abnormal heart and the corrective procedures adopted. Necrotizing enterocolitis is one of the dreaded complications associated with this cohort and impacts the course of these babies in the hospital in a major way. A large majority of term babies with NEC are in the backdrop of a significant congenital cardiac lesion. This review article summarizes the literature and elaborates this entity including its specific features, risk factors associated with its causality, histopathology and related aspects of hemodynamics, and feeding in this vulnerable population. It also provides insight into modifiable risk factors and early markers of detection of gut necrosis to facilitate prevention and early detection. It highlights the subtle but definite difference in outcome variables to help physicians enable the parents of babies with heart disease to develop a better understanding of the entity and its expected course while counseling.
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