Outcomes of Pregnancies Complicated by Preterm Premature Rupture of Membranes Between 20 and 24 Weeks of Gestation

Abstract

Expectant management in pregnancies complicated by previable preterm PROM between 20 and 23 6/7 weeks of gestation is associated with an overall neonatal survival rate of 49.0%, high risk of short- and long-term severe morbidity among survivors, and carries considerable maternal risks.

Preterm premature rupture of membranes at 22–25 weeks’ gestation: perinatal and 2-year outcomes within a national population-based study (EPIPAGE-2)

“…Small sample sizes do not provide precise estimations. 2,6,20 Finally, published studies feature a retrospective design over 5e15 years, 6,18,20 but medical practices may have evolved and mortality rates may decrease. 29 Therefore, comparing our findings with previous publications is challenging.…”

“…The frequency of the other obstetric complications (placental abruption, cord prolapse, and chorioamnionitis) is lower than or similar to that previously described. 2,6,19,20 With PPROM at 22e25 weeks' gestation, perinatal outcomes appear to be influenced by medical practices, which are themselves affected by the resuscitation threshold considered in France in 2011 (24 weeks). 24,28,30,31 This hypothesis requires further investigation.…”

Perinatal Outcomes of Pre-viable Preterm Premature Rupture of Membranes

“…Of these, 38 were selected for full text article review. Finally, 18 articles [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] were included in the review. Figure 1 shows the whole process of study selection, using PRISMA flow diagram [26].…”

The use of maternal delta neutrophil index for the prediction of chorioamnionitis in very early preterm premature rupture of membraneThe use of maternal delta neutrophil index for the prediction of chorioamnionitis in very early preterm premature rupture of membranes

“…In their retrospective study, Kibel et al reviewed the results of 104 pregnant women who were complicated with preterm premature rupture of membranes between 20 and 24 weeks of gestation, and found chorioamnionitis rate as 42.3%. [10] The presence of different chorioamnionitis rates reported in pregnancies complicated with preterm premature rupture of membranes between 20 and 26 weeks of gestation, which is called periviable period of pregnancy, is considered to be the result of different diagnosis criteria for chorioamnionitis used in the studies and reporting only clinical chorioamnionitis rates without assessing histological chorioamnionitis in most of the studies.…”