Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas

Nakhleh, Afif; Naffa, Mai Assaliya; Sviri, Gill E.; Shehadeh, Naim; Hochberg, Irit

doi:10.1007/s11102-020-01124-1

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…Clinically, microadenomas can only have endocrine manifestations, with visual impairment not being obvious and slow growth of the tumor. Patients often seek medical diagnosis when they present with headaches, visual impairment, visual field defects, and hypophysis ( 30 ). With the growth of the tumor, long-term compression of the optic nerve and pituitary tissue will lead to irreversible damage.…”

Section: Discussionmentioning

confidence: 99%

Analysis of perioperative negative emotion risk factors in patients with pituitary adenoma and its impact on prognosis: a retrospective study

Gao¹,

Sen²,

Zhang³

et al. 2022

Gland Surg

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Background: Pituitary adenoma (PA) is the third most common tumor in craniocerebral surgery. Most patients will experience varying degrees of negative emotions before and after surgery, which may affect the prognosis of surgery. This study analyzed the perioperative negative emotional risk factors of patients with different characteristics of PA and their impact on prognosis, so as to provide a reference for improving the prognosis of patients with PA.Methods: A total of 234 patients who underwent PA surgery in the Affiliated Hospital of Nantong University from January 2017 to January 2022 were selected as the observation population. The general characteristics of the subjects were collated using a general information questionnaire designed by the researchers. The negative emotions of the patients were evaluated using a Self-rating Anxiety Scale (SAS) and a Self-rating Depression Scale (SDS). The prognosis of patients was determined by assessing the hypophyseal hormone levels. Multiple regression analysis and logistic regression were used to analyze the risk factors of perioperative negative emotions and the effects of negative emotions on patient prognosis.Results: Multiple regression analysis showed that with and without children, education, income, PA type, PA size, and surgical approach were independent factors influencing negative emotions in patients after PA surgery (P<0.05). Logistic regression analysis showed that negative emotion was an independent prognostic factor (P<0.05).Conclusions: There are many factors that affect the anxiety and depression of patients after PA surgery.The family members and medical staff of the patients should take effective measures to relieve the anxiety and depression of the patients so as to improve the prognosis of patients according to the influencing factors.

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Section: Discussionmentioning

confidence: 99%

Analysis of perioperative negative emotion risk factors in patients with pituitary adenoma and its impact on prognosis: a retrospective study

Gao¹,

Sen²,

Zhang³

et al. 2022

Gland Surg

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“…Patients with a pituitary macroadenoma also more commonly exhibit long term pituitary hormone deficiencies following PA [7].…”

Section: Discussionmentioning

confidence: 99%

“…Although there are inconsistencies in the literature surrounding the differential incidence of PA associated with the various types of pituitary adenomas, PA is more common in patients with a pituitary macroadenoma [ 2 - 4 , 6 ]. Patients with a pituitary macroadenoma also more commonly exhibit long term pituitary hormone deficiencies following PA [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Pituitary Apoplexy (PA): Delayed Diagnosis of a Rare Clinical Syndrome in a Patient With a Known Pituitary Adenoma

Mehkri¹,

Leone²,

Sharaf³

et al. 2022

Cureus

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Pituitary apoplexy (PA) is a rare clinical syndrome in which the pituitary gland undergoes infarction or hemorrhage, predominantly in the setting of an underlying tumor. We report on apoplexy of an expanding pituitary macroadenoma that was compressing the optic chiasm in a patient with progressively worsening neurologic deficits. Due to the patient's rapidly declining clinical status and family's goals of care, no neurosurgical intervention took place, and the patient expired a few days following discharge to hospice. This case highlights the importance of early suspicion for apoplexy in a patient with a history of pituitary adenoma and signs of neurologic deficit.

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“…In fact, NFPAs are more frequent and generally larger than functional adenomas and, for this reason; pituitary apoplexy could be more frequent in these types of tumors. In addition, data from hospitalized patients suggest that pituitary apoplexy is less frequent and has a more favorable prognosis in microadenoma [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms

Biagetti

Simó

2022

IJMS

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Pituitary apoplexy is a rare syndrome, graded from asymptomatic subclinical apoplexy to a life-threatening condition due to pituitary ischemia or haemorrhage of an enlarged pituitary gland. The risk factors and the molecular underlying mechanisms are yet to be elucidated. We provide an overview of the general concepts, the potential factors associated with pituitary adenoma susceptibility for apoplectic events and the molecular mechanisms that could be involved such as HIF-1α/VEGF pathways and metalloproteinases activation, among others. The knowledge of the molecular mechanisms that could participate in the pathogenesis of pituitary apoplexy is crucial to advancement in the identification of future diagnostic tools and therapeutic targets in this rare but sometimes fatal condition.

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Outcomes of pituitary apoplexy: a comparison of microadenomas and macroadenomas

Cited by 9 publications

References 12 publications

Analysis of perioperative negative emotion risk factors in patients with pituitary adenoma and its impact on prognosis: a retrospective study

Analysis of perioperative negative emotion risk factors in patients with pituitary adenoma and its impact on prognosis: a retrospective study

Pituitary Apoplexy (PA): Delayed Diagnosis of a Rare Clinical Syndrome in a Patient With a Known Pituitary Adenoma

Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms

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