Outcomes of Patients With Multidrug-Resistant Pulmonary Tuberculosis Treated With Ofloxacin/Levofloxacin-Containing Regimens

Multidrug Resistant Tuberculosis; a Pharmacological view based on Revised National Tuberculosis Control Programme DOTS-Plus Guidelines.

“…Ofloxacin (Quinolones) 13,14 Gastro intestinal symptoms: diarrhea, vomiting, and abdominal pain, central nervous system (CNS): dizziness and convulsions, phototoxicity and photosensitivity, tendinopathy and tendinitis nephrotoxicity skin rash cardiotoxicity arthralgia Ethambutol Visual disturbance Pyrazinamide Arthralgia , hyperuricaemia , hepatitis, pruritis with or without rash Ethionamide Gastro-intestinal: epigastric discomfort, anorexia, nausea, metallic taste, vomiting, excessive salivation, and sulfurous belching psychiatric: hallucination and depression ,hepatitis ,hypothyroidism and goitre with prolonged administration, gynaecomastia, menstrual disturbances, impotence, acne, headache, and peripheral neuropathy Cycloserine. 15 CNS: dizziness, slurred speech, convulsions, headache, tremor, and insomnia , psychiatric: confusion, depression, altered behaviour, and suicidal tendency, hypersensitivity reaction PAS Gastro-intestinal: anorexia, nausea, vomiting, and abdominal discomfort, skin rash, hepatic dysfunction hypokalemia, hypothyroidism and goitre with prolonged administration.…”

Role of fluoroquinolones in the treatment of tuberculosis

“…The FQs, particularly new generation FQs such as LFX, MFX and GFX due to their potent bactericidal activity and lack of cross-resistance with existing anti-TB drugs, have also been used extensively for the treatment of drug-resistant TB and are now regarded as one of the two most important second-line agents for the treatment of MDR-TB [22,28,31,36,51,52]. Several studies have shown that inclusion of a FQ (particularly mFQs) and an injectable aminoglycoside (kanamycin or amikacin) or cyclic peptide (capreomycin and viomycin) in multidrug treatment regimens has the maximum effect for a more favorable outcome in the treatment of MDR-TB [12][13][14][51][52][53][54]. This is also apparent from the fact that development of resistance of MDR-TB strains to FQs is associated with poor treatment outcome.…”

Multidrug-resistant tuberculosis: case reports study in a central state of Brazil

“…The same patient refused to use E due to severe nausea and vomiting. The regimens containing fluoroquinolones like ofloxacin and levofloxacin are being related with better prognosis in MDR-TB patients [20]. Different treatment strategies can be adopted in MDR-TB cases.…”