Outcomes of Pancreas Retransplantation.

Rudolph, E.; Chandolias, Nikolaos; Finger, Erik B.; Kandaswamy, Raja; Sutherland, David E.R.; Dunn, Ty B.

doi:10.1097/00007890-201407151-00633

Cited by 2 publications

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“…Studies on the outcome of pancreas retransplantation after fail- As patient mortality and technical failure were not increased after pancreas retransplantation in the large Minnesota cohort, pancreas retransplantation can be considered a procedure as safe as the first transplantation. 23 However, it is important to point out that the mean recipient age in this cohort was less than 45 years. Higher patient age, with an increased disease burden and frequency of cardiovascular morbidity and vascular disease, may increase technical problems as well as the complication risk in pancreas retransplantation.…”

Section: Discussionmentioning

confidence: 84%

Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation

Gerber

Hochuli

Benediktsdottir

et al. 2017

Clinical Transplantation

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The aim of this study was to assess safety and efficacy of islet transplantation after initial pancreas transplantation with subsequent organ failure. Patients undergoing islet transplantation at our institution after pancreas organ failure were compared to a control group of patients with pancreas graft failure, but without islet transplantation and to a group receiving pancreas retransplantation. Ten patients underwent islet transplantation after initial pancreas transplantation failed and were followed for a median of 51 months. The primary end point of HbA1c <7.0% and freedom of severe hypoglycemia was met by nine of 10 patients after follow-up after islet transplantation and in all three patients in the pancreas retransplantation group, but by none of the patients in the group without retransplantation (n = 7). Insulin requirement was reduced by 50% after islet transplantation. Kidney function (eGFR) declined with a rate of -1.0 mL ± 1.2 mL/min/1.73 m 2 per year during follow-up after islet transplantation, which tended to be slower than in the group without retransplantation (P = .07). Islet transplantation after deceased donor pancreas transplant failure is a method that can safely improve glycemic control and reduce the incidence of severe hypoglycemia and thus establish similar glycemic control as after initial pancreas transplantation, despite the need of additional exogenous insulin. K E Y W O R D Sinsulin, islet transplantation, pancreas transplantation, type 1 diabetes mellitus

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Section: Discussionmentioning

confidence: 84%

Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation

Gerber

Hochuli

Benediktsdottir

et al. 2017

Clinical Transplantation

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What’s Hot, What’s New at WTC—Clinical Science

Mueller¹,

Oberkofler²,

Clavien³

2015

American Journal of Transplantation

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More than 3000 abstracts of innovative and exciting findings, covering the whole field of organ transplantation, were presented at the World Transplant Congress 2014. Key areas of presentations across all organs and tissues included HLA antibodies, antibodymediated rejection, living donation, immunosuppression, organ perfusion and surgical procedures. In addition, cutting edge science and future perspectives were presented in state-of-the-art lectures. This review will present highlights of this meeting and demonstrate strength and success of clinical sciences in transplantation.

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Outcomes of Pancreas Retransplantation.

Cited by 2 publications

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Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation

Islet transplantation as safe and efficacious method to restore glycemic control and to avoid severe hypoglycemia after donor organ failure in pancreas transplantation

What’s Hot, What’s New at WTC—Clinical Science

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