Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study

Ovarian involvement in endometrioid adenocarcinoma of uterus

“…Wright et al have performed population-based analysis and demonstrated the safety and feasibility of ovarian preservation [8]. Similarly, Lee et al have also shown in two separate reports that ovarian preservation in premenopausal women with early stage endometrial cancer is not associated with worse outcomes [2,7]. Richter et al reported that BSO leads to better disease-free survival in young endometrial cancer patients, but does not affect the overall survival [9].…”

“…Our findings support the concept of ovarian preservation in premenopausal women with corpus confined endometriod endometrial cancer in the absence of other poor prognostic factors. Previous studies have also reported an isolated microscopic ovarian involvement rate of approximately 1% and emphasized the safety and feasibility of ovarian preservation in premenopausal women undergoing surgery for endometrial cancer [2,3,7,8].…”

“…Several studies have shown that ovarian preservation in patients with early stage endometrial cancer does not negatively impact survival outcomes [2,[6][7][8]. Other authors have reported that bilateral salpingo-oophorectomy may be associated with better disease-specific survival in young patients with endometrial preservation vs. oophorectomy [9].…”

New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis

“…COX-2 expression has been found to be associated with an increased risk of tumor recurrence, advanced cancer stage and/ or poor overall survival in a large number of cancers such as ovarian cancer [28,29], osteosarcoma [30,31], pancreatic cancer [32], gastric cancer [33][34][35], classical Hodgkin's lymphoma [36], oral squamous cell cancer [37], melanoma [38], non-small cell lung cancer [39] but not lung adenocarcinoma [40], clear cell renal carcinoma [41], cervical cancer [42] and esophageal adenocarcinoma [43]. The specific expression of COX-2 in breast and colon cancers is detailed later in this article.…”

Take 'em or leave 'em: Management of the ovaries in young women with endometrial cancer

“…Recurrence rates were 2.3% in those who had ovarian conservation compared to 2.5% in those who underwent oophorectomy, while fiveyear survival was 94.5% compared to 97.8%, respectively. Importantly, none of the women who had ovarian conservation subsequently developed a primary ovarian malignancy and only one of the recurrences in the ovarian conservation group was in the adnexa [5].…”