Outcomes of outborn very-low-birth-weight infants in Japan

Hirata, Katsuya; Kimura, Takeshi; Hirano, Shinya; Wada, Kazuko; Kusuda, Satoshi; Fujimura, Masanori

doi:10.1136/archdischild-2019-318594

Cited by 21 publications

(33 citation statements)

References 38 publications

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“…10 In a retrospective cohort study of preterm infants in Japan from 2003 to 2012, Nakanishi et al found that the mortality rate was 6.5%, 7 whereas from 2012 to 2016, Hirata et al reported a mortality rate of 4.1%. 8 Considering these data, the mortality rate in the present study seemed to be very low, especially in the extremely LBW group (5.2%). A study including a multicenter, multinational cohort of preterm infants among eight members of the International Network for Evaluating Outcomes spanning nine countries 11 —and more recently a study of neonatal outcomes in 11 high-income countries 12 —, found that mortality was lowest in Japan.…”

Section: Discussionmentioning

confidence: 43%

“…6 In a retrospective cohort study of preterm infants treated from 2003 to 2012 in Japan, Nakanishi et al found that the rates of IVH were 14.1% from 2003 to 2007 and 14.0% from 2008 to 2012, whereas the equivalent figures for infants with severe IVH were 5.6 and 4.3%, respectively. 7 From the period of 2012 to 2016, Hirata et al 8 reported that the overall rate of severe IVH was 4.3%, whereas that of IVH of any grade was 13.3%.…”

Section: Discussionmentioning

confidence: 99%

“…Unauthorized distribution is strictly prohibited.equivalent figures for infants with severe IVH were 5.6 and 4.3%, respectively 7. From the period of 2012 to 2016, Hirata et al8 reported that the overall rate of severe IVH was 4.3%, whereas that of IVH of any grade was 13.3%.…”

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confidence: 99%

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The Incidence of Intraventricular Hemorrhage in Low-Birth-Weight Infants: Assessment by Magnetic Resonance Imaging

et al. 2022

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Purpose Intraventricular hemorrhage (IVH) is common in infants with a low-birth-weight (LBW) and has been suggested to cause major impairment not only of future motor development but also of cognitive function and learning ability. The purpose of the present study is to assess the frequency of IVH using magnetic resonance imaging (MRI) in LBW infants and its clinical neurodevelopmental outcomes. Methods We enrolled a consecutive series of 247 neonates with an LBW of < 1,500 g hospitalized in the newborn intensive care unit between 2010 and 2015. The presence of IVH was examined using T2* MRI at term-equivalent age (TEA). We then investigated the clinical outcome at ≥3 years of age and its correlation with the IVH grade. Results The overall incidence of IVH among LBW infants was 16.2%. The proportion of infants with IVH showing a favorable outcome did not differ significantly from that of infants without IVH. The proportion of neonates showing a poor outcome was 6.7% for those with IVH and 1.9% for those without IVH and 2.7% for those with and without IVH combined. Conclusion We were able to clarify the frequency of IVH in LBW infants using MRI at TEA. We demonstrated the lower incidence of mortality and IVH, the higher incidence of a favorable outcome, and the lower incidence of poor outcome.

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Section: Discussionmentioning

confidence: 43%

Section: Discussionmentioning

confidence: 99%

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The Incidence of Intraventricular Hemorrhage in Low-Birth-Weight Infants: Assessment by Magnetic Resonance Imaging

et al. 2022

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“…Meanwhile, the rate of IVH stands at around 20–38% in children under 28 weeks of gestational age (GA) and is more frequent in the first 72 h of life [ 19 , 20 ]. Thus, the risk of bleeding is inversely related to gestational age and can be attributed to three factors: vascular immaturity of the germinal matrix, deficient extravascular matrix, and cerebral blood flow alterations.…”

Section: Introductionmentioning

confidence: 99%

Lateral Kangaroo Care in Hemodynamic Stability of Extremely Preterm Infants: Protocol Study for a Non-Inferiority Randomized Controlled Trial CANGULAT

Collados-Gómez

Esteban‐Gonzalo

López-López

et al. 2021

IJERPH

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Introduction: This study aims to assess the efficacy of the modified kangaroo care lateral position on the thermal stability of preterm neonates versus conventional kangaroo care prone position. Material and methods: A non-inferiority randomized parallel clinical trial. Kangaroo care will be performed in a lateral position for the experimental group and in a prone position for the control group preterm. The study will take place at the neonatal intensive care unit (NICU) of a University Hospital. The participants will be extremely premature infants (under 28 weeks of gestational age) along the first five days of life, hemodynamically stable, with mother or father willing to do kangaroo care and give their written consent to participate in the study. The sample size calculated was 35 participants in each group. When the premature infant is hemodynamically stable and one of the parents stays in the NICU, the patient will be randomized into two groups: an experimental group or a control group. The primary outcome is premature infant axillary temperature. Neonatal pain level and intraventricular hemorrhage are secondary outcomes. Discussion: There is no scientific evidence on modified kangaroo care lateral position. Furthermore, there is little evidence of increased intraventricular hemorrhage association with the lateral head position necessary in conventional or prone kangaroo care in extremely premature newborns. Kangaroo care is a priority intervention in neonatal units increasing the time of use more and more, making postural changes necessary to optimize comfort and minimize risks with kangaroo care lateral position as an alternative to conventional prone position kangaroo care. Meanwhile, it is essential to ensure that the conventional kangaroo care prone position, which requires the head to lay sideways, is a safe position in terms of preventing intraventricular hemorrhage in the first five days of life of children under 28 weeks of gestational age. Trial registration at clinicaltrials.gov: NCT03990116.

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“…Centralisation of perinatal care in tertiary hospitals reduces their mortality and morbidity (1)(2)(3). Infants born outside a tertiary centre and who require transport after birth have an increased risk of intracranial haemorrhage (ICH), necrotising enterocolitis, spontaneous intestinal perforation and pulmonary haemorrhage (4)(5)(6)(7)(8)(9). In some populations, this has translated into long-term neurodevelopmental impairment (7,10,11).…”

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confidence: 99%

Short and long-term outcomes of outborn vs. inborn infants <32 weeks’ in Western Australia: A cohort study of infants born between 2005 and 2018

Davis

Seeber

Nathan

et al. 2022

Preprint

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Objective: To compare mortality and morbidity of inborn vs outborn very preterm infants <32 weeks in Western Australia between 2005 and 2018. Design: Retrospective cohort study Patients: Infants <32 weeks born in Western Australia. Main outcome measures: Mortality was assessed as death before discharge home from the tertiary NICU. Clinically significant short-term morbidities included combined brain injury (intracranial haemorrhage (ICH) Grade 3 and cystic periventricular leukomalacia (cPVL)) and other important major neonatal outcomes. Standardised developmental assessments up to 5 years of age were evaluated where available. We performed multivariable logistic regression analysis of outborn status on outcomes, controlling for gestational age, birthweight z score, sex and multiple birth. Results: A total of 4974 infants were born in WA between 22 and 32 weeks gestation between 2005 and 2018 of which 4237 (89.6%) inborn and 443 (10.4%) outborn were compared. Overall mortality to discharge was higher in outborn infants (20.5% (91/443) vs. 7.4% (314/4237); aOR 2.44, 95% CI 1.60;3.70, p<0.001). Outborn infants had higher rates of combined brain injury than those inborn (10.7% (41/384) vs. 6.0% (246/4115); adjusted OR 1.98, 95% CI 1.37;2.86), p<0.001). No difference in long term neurodevelopmental measures was detected, however, long-term follow-up data were available for only 65% of outborn and 79% of inborn infants. Conclusions: Outborn preterm infants <32 weeks in WA have increased odds of mortality, and combined brain injury than those inborn. Long-term outcome results is likely to be affected by incomplete follow-up data.

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Outcomes of outborn very-low-birth-weight infants in Japan

Cited by 21 publications

References 38 publications

The Incidence of Intraventricular Hemorrhage in Low-Birth-Weight Infants: Assessment by Magnetic Resonance Imaging

The Incidence of Intraventricular Hemorrhage in Low-Birth-Weight Infants: Assessment by Magnetic Resonance Imaging

Lateral Kangaroo Care in Hemodynamic Stability of Extremely Preterm Infants: Protocol Study for a Non-Inferiority Randomized Controlled Trial CANGULAT

Short and long-term outcomes of outborn vs. inborn infants <32 weeks’ in Western Australia: A cohort study of infants born between 2005 and 2018

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