Outcomes of Osteochondral Allograft Transplantation With and Without Concomitant Meniscus Allograft Transplantation: A Comparative Matched Group Analysis

Frank, Rachel M.; Lee, Simon; Cotter, Eric J.; Hannon, Charles P.; Leroux, Timothy; Cole, Brian J.

doi:10.1177/0363546517744202

Cited by 53 publications

(42 citation statements)

References 43 publications

(31 reference statements)

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“…One is the “biological knee replacement” combining MAT with ACI as reported by Bhosale et al [ 9 ] from Oswestry, but with a series of only eight patients. The other is to combine MAT with osteochondral allografts, as reported by Abrams et al [ 2 ] and Frank et al [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Waugh

Mistry

Metcalfe

et al. 2019

Knee Surg Sports Traumatol Arthrosc

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Purpose To assess the clinical effectiveness and cost-effectiveness of meniscal allograft transplantation (MAT) after meniscal injury and subsequent meniscectomy. Methods Systematic review of clinical effectiveness and cost-effectiveness analysis. Results There is considerable evidence from observational studies, of improvement in symptoms after meniscal allograft transplantation, but we found only one small pilot trial with a randomised comparison with a control group that received non-surgical care. MAT has not yet been proven to be chondroprotective. Cost-effectiveness analysis is not possible due to a lack of data on the effectiveness of MAT compared to non-surgical care. Conclusion The benefits of MAT include symptomatic relief and restoration of at least some previous activities, which will be reflected in utility values and hence in quality-adjusted life years, and in the longer term, prevention or delay of osteoarthritis, and avoidance or postponement of some knee replacements, with resulting savings. It is likely to be cost-effective, but this cannot be proven on the basis of present evidence. Level of evidence IV. Electronic supplementary material The online version of this article (10.1007/s00167-019-05504-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Waugh

Mistry

Metcalfe

et al. 2019

Knee Surg Sports Traumatol Arthrosc

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“…12,18,38 Additionally, several comparative studies suggested that ACL reconstruction and meniscal allograft transplantation do not negatively affect the patient-reported outcomes of OCA. 11,39,41…”

Section: Discussionmentioning

confidence: 99%

Clinically Meaningful Improvement After Treatment of Cartilage Defects of the Knee With Osteochondral Grafts

et al. 2018

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Background: Mosaicplasty and fresh osteochondral allograft transplantation (OCA) are popular cartilage restoration techniques that involve the single-stage implantation of viable, mature hyaline cartilage-bone dowels into chondral lesions of the knee. Recently, there has been greater focus on what represents a clinically relevant change in outcomes reporting, and commonly applied metrics for measuring clinical significance include the minimal clinically important difference (MCID) and substantial clinical benefit (SCB). Purpose: To define the MCID and SCB after mosaicplasty or OCA for the International Knee Documentation Committee (IKDC) subjective form and Knee Outcome Survey-Activities of Daily Living (KOS-ADL) and to determine patient factors that are predictive of achieving the MCID and SCB after mosaicplasty or OCA.

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“…Similar results were reported by Harris et al 68 in patients treated with combined corrective osteotomy, MAT, and cartilage procedures (12 OCAs). Frank et al 87 compared, with a mean follow-up of 5 years, patients who underwent femoral OCA and associated MAT with patients without associated MAT. Graft survivorship was 86% at 5 years.…”

Section: Literature Reviewmentioning

confidence: 99%

Large Osteochondral Allografts of the Knee: Surgical Technique and Indications

Pisanu

Cottino

Rosso

et al. 2018

Joints

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Large osteochondral allograft (OCA) transplant has become a valid alternative to restore articular surface in challenging articular lesions in young and active patients, either in primary or in revision procedures. Several studies support the effectiveness and safety of OCA, but costs and graft availability limit their use. The indications are the treatment of symptomatic full-thickness cartilage lesions greater than 3 cm 2 , deep lesions with subchondral damage, or revision procedures when a previous treatment has failed. The goal of the transplant is to restore the articular surface with a biological implant, allow return to daily/sports activities, relieve symptoms, and delay knee arthroplasty. Grafts can be fresh, fresh-frozen, or cryopreserved; these different storage procedures significantly affect cell viability, immunogenicity, and duration of the storage. Dowel and shell technique are the two most commonly used procedures for OCA transplantation. While most cartilage lesions can be treated with the dowel technique, large and/or geometrically irregular lesions should be treated with the shell technique. OCA transplantation for the knee has demonstrated reliable mid- to long-term results in terms of graft survival and patient satisfaction. Best results are reported: in unipolar lesions, in patients younger than 30 years, in traumatic lesions and when the treatment is performed within 12 months from the onset of symptoms.

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Outcomes of Osteochondral Allograft Transplantation With and Without Concomitant Meniscus Allograft Transplantation: A Comparative Matched Group Analysis

Cited by 53 publications

References 43 publications

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Meniscal allograft transplantation after meniscectomy: clinical effectiveness and cost-effectiveness

Clinically Meaningful Improvement After Treatment of Cartilage Defects of the Knee With Osteochondral Grafts

Large Osteochondral Allografts of the Knee: Surgical Technique and Indications

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