Outcomes of Moderately Preterm Infants of Insulin-Dependent Diabetic Mothers

Abstract

Objective: Little is known about the hospital outcomes of moderately preterm (MPT, 29 0/7 -33 6/7 weeks gestational age) infants born to insulin-dependent diabetic mothers (IDDM). We evaluated characteristics and outcomes of MPT infants born to IDDMs compared to those without IDDM (non IDDM). Study Design: Cohort study of infants from 18 centers included in the MPT Infants database from 2012-2013. We compared characteristics and outcomes of infants born to IDDMs and non IDDMs. Results: Of 7036 infants, 527 (7.5%) were born to IDDMs. Infants of IDDMs were larger at birth, more often received CPAP in the delivery room, and had higher risk of patent ductus arteriosus (adjusted relative risk or aRR 1.49, 95% CI 1.20-1.85) and continued hospitalization at 40 weeks postmenstrual age (aRR 1.55, 95% CI 1.18-2.05). Conclusions: MPT infants of IDDM received more respiratory support and prolonged hospitalizations, providing further evidence of the important neonatal health consequences of maternal diabetes.