Outcomes of long‐pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review

Abstract

Background and Objective Recent prospective trials have supported treatment of nonfacial BCC with long‐pulsed 1064 nm Nd:YAG laser based on short‐term histologic clearance rates. Studies have yet to identify the long‐term clinical clearance rates of this specific laser therapy for BCC. Study Design/Material and Methods This is a retrospective review of BCC treated with long‐pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area. Results 16 BCC lesions (11 subjects) treated with 1064 nm Nd:YAG laser were enrolled. Our analysis revealed 100% clearance rate in all subjects (16 of 16 BCC) treated with long‐pulsed Nd:YAG laser based on mean follow‐up of 9 months (range 6–15 months). Minimal scarring and no long‐term adverse events were noted. Conclusions This study supports the use of 1064 nm Nd:YAG laser as a therapeutic modality for BCC based on the absence of clinical recurrence upon a mean follow‐up of 9 months. As studies progress, we are beginning to observe a potential role for laser as an alternative to patients who refuse surgery, have multiple co‐morbidities, or decline non‐surgical therapies. Laser treatment with 1064 nm Nd:YAG is an evolving, promising story that we continue to investigate to optimize parameters. Lasers Surg. Med. 51:34–39, 2019. © 2018 Wiley Periodicals, Inc.

Assessing the Outcomes of Focused Heating of the Skin by a Long‐Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

“…This combination of enhanced tolerability and indiscriminate tissue destruction has been exploited to eradicate low-risk skin cancers. Remarkable clearance and minimal recurrence have been achieved when using the LP 1064 nm laser for the treatment of basal cell carcinomas [27][28][29][30]. However, while the destruction of skin cancers with aggressive settings on a deeply penetrating laser may be clinically effective, adverse effects such as ulceration, prolonged healing, and unfavorable scarring would be inevitable and inconvenient for patients.…”

“…It is commonly used for the destruction of vascular skin lesions and hair removal with hemoglobin and melanin its target chromophores. Its ability to eradicate skin tumors has also been explored [26–30]. However, we do not believe that this process is predominantly vascular specific.…”

3D-MID Technology for Surface Modification of Polymer-Based Composites: A Comprehensive Review

“…This is in contrast to PP and PE which the absorption occurs within much thicker layer. Some of additives such as polyolefin and benzophenone are being used for the improvement of UV and UV-Vis light absorption [252][253][254][255]. The specific heat and thermal diffusion constant of the polymeric material can be a concern because they are related to minimization of thermal damages into material.…”

Evaluation of a 3.8-µm laser-induced skin injury and their repair with in vivo OCT imaging and noninvasive monitoring

“…The biological effects of different lasers, such as near-infrared lasers [9,10] and visible lasers, have been investigated for laser treatment. These lasers are widely used in the treatment of skin diseases [11,12], such as skin scars [13] and skin rejuvenation [10]. In our previous research, we used macroscopic observations and histological sections to quantitatively and qualitatively evaluate the recovery process of 1064-nm laser-induced skin injury [14].…”