Outcomes of living liver donors are worse than those of matched healthy controls

2022 KLCA-NCC Korea practice guidelines for the management of hepatocellular carcinoma

“…However, in the early days of LDLT, the probabilities of death and life-threatening complications in healthy donors have been reported to be 0.2–0.3% and about 2% globally, respectively [ 458 , 462 - 465 ]. Recent long-term outcomes of 12,372 donors also reported higher mortality and disease prevalence in liver donors compared to the healthy control group (mortality rate 0.91 in 1,000 population) [ 466 ]. Due to the complexity of the procedure, LDLT must be restricted to centers of expertise in hepatic surgery and LT to minimize donor risk and maximize recipient outcome.…”

Changes in Awareness Toward Minor’s Organ Donation Through Structured Information; Survey

“…Geir et al ( 19 ) reported that the risk of major complications related to living donor nephrectomy is low but represents a potential hazard to the donor. Hong et al ( 13 ) and Choi et al ( 13 , 14 ) analyzed the long-term results of living donor liver transplantation using the big data of Korea’s national health insurance and concluded that liver donors have increased long-term mortality risk compared to similar control groups without contraindications to be organ donors, the leading cause of mortality being suicide. The impact of donation on the lives of minors as donors has not been appropriately analyzed, although previous studies using big data showed that physical changes or psychological pain for minors would be significant and that minors may have more difficulty maintaining their mental and physical health ( 20 ).…”

“…Moreover, the issue of instability, which occurs when minors decide to donate their organs, has to be addressed. Therefore, there is a need to reassess the organ donation of minors ( 13 , 14 ).…”

2022 KLCA-NCC Korea Practice Guidelines for the Management of Hepatocellular Carcinoma

“…However, in the early days of LDLT, the probabilities of death and life-threatening complications in healthy donors have been reported to be 0.2%–0.3% and about 2% globally, respectively [ 458 462 463 464 465 ]. Recent long-term outcomes of 12372 donors also reported higher mortality and disease prevalence in liver donors compared to the healthy control group (mortality rate 0.91 in 1000 population) [ 466 ]. Due to the complexity of the procedure, LDLT must be restricted to centers of expertise in hepatic surgery and LT to minimize donor risk and maximize recipient outcome.…”