Outcomes of Laparoscopic Surgery in Colorectal Cancer Patients With Dialysis

Higashino, Nobuhide; Matsuda, Takeru; Hasegawa, Hiroshi; Yamashita, Kimihiro; Sakamoto, Hiroki; Fujikawa, Masataka; Yamamoto, Masashi; Kanaji, Shingo; Oshikiri, Taro; Suzuki, Satoshi; Kakeji, Yoshihiro

doi:10.21873/anticanres.14176

Cited by 9 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to previous studies reporting that the rate of morbidity and mortality related to CRF was higher, our study showed the same result: the rate of complications of CRF patients on dialysis were higher (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). In previous studies investigating laparoscopic colon surgery for dialysis patients, Higashino et al and Obara et al reported that there were no significant differences in operative outcomes and postoperative short-term outcomes between dialysis patients and other patients (20,21). In our study, the fact of that the rate of open surgery in Group A was higher may have had a strong impact on the result.…”

Section: Discussioncontrasting

confidence: 39%

Short-term Postoperative Outcomes of Colorectal Cancer Patients With Chronic Renal Failure on Dialysis

Neki

Takeda

Kosuge

et al. 2022

In Vivo

View full text Add to dashboard Cite

Background/Aim: Surgery for dialysis patients requires special attention because of their physical characteristics. This study aimed to investigate the shortterm postoperative outcomes of colorectal cancer patients with chronic renal failure (CRF) on dialysis and aimed to investigate safer treatment options for these patients. Patients and Methods: A total of 1,504 colorectal cancer patients who underwent primary resection between January 2008 and December 2018 were included. A retrospective analysis of clinical data, preoperative tumor markers (carcinoembryonic antigen and carbohydrate antigen 19-9), and the Clavien-Dindo (CD) classification was performed. Patients were stratified into Groups A and B based on their need for dialysis or not, respectively. Results: There were 20 and 1,484 patients in Groups A and B, respectively. No differences were observed regarding age, body mass index, and preoperative tumor markers. The rate of laparoscopic surgery was significantly lower in Group A than in Group B. There was one mortality in Group A due to pulmonary disease. Group A had a significantly higher rate of complications. Conclusion: CRF patients on dialysis who underwent colorectal cancer surgery tended to be ruled out of laparoscopic surgery, and their rates of postoperative complications were higher.

show abstract

Section: Discussioncontrasting

confidence: 39%

Short-term Postoperative Outcomes of Colorectal Cancer Patients With Chronic Renal Failure on Dialysis

Neki

Takeda

Kosuge

et al. 2022

In Vivo

View full text Add to dashboard Cite

show abstract

“…The NOS score and definitions of the CKD group and the non-CKD group are shown in Table 1 . Six studies reported that the modification of diet in renal disease equation was used to estimate the estimated glomerular filtration rates (eGFR)[ 16 , 18 , 25 , 27 - 29 ]; however, the method used in the other studies was unclear[ 15 , 17 , 26 ] (see Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, these events might increase the risk of lung-related complications[ 18 ]. Cardiovascular complications might be associated with endothelial dysfunction in CKD patients[ 16 , 34 ]. Furthermore, patients with CKD are in a relatively immunosuppressive state due to nutritional deficiencies, the lymphocyte suppression and the loss of serum immune system components, which might result in an increase in infectious diseases and short-term deaths after surgery[ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…As previous studies reported, patients with CKD might increase the risk of CRC[ 14 ]; however, the effect of CKD on complications and prognosis after CRC surgery remains controversial. Some studies held the view that CKD had no effect on surgical complications[ 15 , 16 ]. Moreover, other studies believed that CKD increased postoperative complications[ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Does chronic kidney disease affect the complications and prognosis of patients after primary colorectal cancer surgery?

Liu¹,

Zhang²,

Cheng³

et al. 2022

WJGO

View full text Add to dashboard Cite

BACKGROUND The effect of chronic kidney disease (CKD) on the outcomes of colorectal cancer (CRC) patients after primary CRC surgery is controversial. AIM To analyze whether CKD had specific effect on the outcomes after CRC surgery. METHODS We searched the PubMed, Embase, Cochrane Library databases and CNKI, from inception to March 14, 2022. Newcastle-Ottawa Scale was used for the quality assessment in this meta-analysis, and we used RevMan 5.3 was used for data analysis. RESULTS A total of nine studies including 47771 patients were eligible for this meta-analysis. No significant difference was found in terms of overall postoperative complications [odds ratio (OR) = 1.78, 95%CI: 0.64-4.94, P = 0.27]. We analyzed the specific complications and found that the CKD group had higher rates of pulmonary infection (OR = 2.70, 95%CI: 1.82-4.00, P < 0.01), cardiovascular complications (OR = 3.39, 95%CI: 2.34-4.91, P < 0.01) and short-term death (OR = 3.01, 95%CI: 2.20-4.11, P < 0.01). After pooling the hazard ratio (HR), the CKD group had worse overall survival (OS) (HR = 1.51, 95%CI: 1.04-2.20, P = 0.03). We performed subgroup analyses of the dialysis and non-dialysis groups, and no significant difference was found in the non-dialysis group (HR = 1.20, 95%CI: 0.98-1.47, P = 0.08). The dialysis group had worse OS (HR = 3.36, 95%CI: 1.92-5.50, P < 0.01) than the non-dialysis group. The CKD group had worse disease-free survival (DFS) (HR = 1.41, 95%CI: 1.12-1.78, P < 0.01), and in the subgroup analysis of the dialysis and non-dialysis groups, no significant difference was found in the non-dialysis group (HR = 1.27, 95%CI: 0.97-1.66, P = 0.08). The dialysis group had worse OS (HR = 1.95, 95%CI: 1.23-3.10, P < 0.01) than the non-dialysis group. CONCLUSION Preexisting CKD was associated with higher rates of pulmonary infection, higher rates of short-term death, and worse OS and poorer DFS following CRC surgery.

show abstract

“…Various conventional treatment methods have been established for CRC, including surgery, chemotherapy, and radiotherapy. Additionally, novel therapies like bio‐targeted therapy, immunotherapy, and precision therapy have been introduced 2–7 . However, the prognosis for advanced CRC patients, especially those with distant metastasis, remains dismal.…”

Section: Introductionmentioning

confidence: 99%

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies

Firouzjaei,

Aghaee‐Bakhtiari,

Tafti

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

Colorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of iron‐dependent controlled cell death, in the context of CRC. Curcumin, a natural compound found in turmeric, exhibits anticancer properties. This study explores the effects of curcumin on genes related to ferroptosis (FRGs) in CRC. To gather CRC data, we used the Gene Expression Profiling Interactive Analysis (GEPIA) and Gene Expression Omnibus (GEO) databases, while FRGs were obtained from the FerrDb database and PubMed. We identified 739 CRC differentially expressed genes (DEGs) in CRC and discovered 39 genes that were common genes between FRGs and CRC DEGs. The DEGs related to ferroptosis were enriched with various biological processes and molecular functions, including the regulation of signal transduction and glucose metabolism. Using the Drug Gene Interaction Database (DGIdb), we predicted drugs targeting CRC‐DEGs and identified 17 potential drug targets. Additionally, we identified eight essential proteins related to ferroptosis in CRC, including MYC, IL1B, and SLC1A5. Survival analysis revealed that alterations in gene expression of CDC25A, DDR2, FABP4, IL1B, SNCA, and TFAM were associated with prognosis in CRC patients. In SW480 human CRC cells, treatment with curcumin decreased the expression of MYC, IL1B, and EZH2 mRNA, while simultaneously increasing the expression of SLCA5 and CAV1. The findings of this study suggest that curcumin could regulate FRGs in CRC and have the potential to be utilized as a therapeutic agent for treating CRC.

show abstract

Outcomes of Laparoscopic Surgery in Colorectal Cancer Patients With Dialysis

Cited by 9 publications

References 20 publications

Short-term Postoperative Outcomes of Colorectal Cancer Patients With Chronic Renal Failure on Dialysis

Short-term Postoperative Outcomes of Colorectal Cancer Patients With Chronic Renal Failure on Dialysis

Does chronic kidney disease affect the complications and prognosis of patients after primary colorectal cancer surgery?

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies

Contact Info

Product

Resources

About