Outcomes of kidney transplantation in HIV-positive patients: the UK experience

Gathogo, Esther; Hamzah, Lisa; Hilton, Rachel; Marshall, Neal; Harber, Mark; Levy, Jeremy; Jones, Rachael; Boffito, Marta; Khoo, Saye; Drage, Martin; Post, Frank A.

doi:10.1016/s0140-6736(13)60483-3

Cited by 2 publications

(1 citation statement)

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“…Tacrolimus is preferred over cyclosporine. 77 Early steroid withdrawal 78,79 and sirolimus-based regimens appear to be associated with higher risk of rejection 76 and are preferably avoided unless there are special considerations related to osteopenia or malignancy (encountered more commonly in this population). Despite anecdotal reports of the successful use of belatacept in kidney transplant recipients with HIV, either de novo, 80 or converted from a CNI, 81,82 it cannot be recommended at present as a standard of care immunosuppressant in this population because of its known risks of acute rejection and of impaired viral clearance; data from clinical trials or large series are needed.…”

Section: Posttransplant Outcomes and Immunosuppression Managementmentioning

confidence: 99%

Expanding Access to Organ Transplant for People Living With HIV: Can Policy Catch Up to Outcomes Data?

Chandran,

Stock,

Roll

2023

Transplantation

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Advances in antiretroviral and immunosuppressive regimens have improved outcomes following solid organ transplantation in people living with HIV (PLWH). The HIV Organ Policy and Equity Act was conceived to reduce the discard of HIV-positive organs and improve access to transplant for PLWH. Nevertheless, PLWH continue to experience disproportionately low rates of transplant. This overview examines the hurdles to transplantation in PLWH with end-organ disease, the potential and realized impact of the HIV Organ Policy and Equity Act, and changes that could permit expanded access to organ transplant in this population.

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