Outcomes of Intravesical Botulinum Toxin for Idiopathic Overactive Bladder Symptoms: A Systematic Review of the Literature

Anger, Jennifer T.; Weinberg, Aviva E.; Suttorp, Marika J; Litwin, Mark S.; Shekelle, Paul G

doi:10.1016/j.juro.2010.02.009

Cited by 111 publications

(78 citation statements)

References 19 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Data abstraction forms were adapted from those previously used in a systematic review conducted to evaluate intravesical botulinum toxin for overactive bladder symptoms. 10 Each table outlined the available data for each case, including patient age, parity, type of incontinence surgery performed, interval between surgery and pregnancy, urinary incontinence status during pregnancy, delivery method, urinary incontinence status after pregnancy, complications after childbirth and followup length. Because of the heterogeneity of patients, outcomes and data collection methods, we were unable to pool the data for statistical analysis in a methodologically sound fashion.…”

Section: Data Abstraction and Synthesis Of Resultsmentioning

confidence: 99%

1765 Outcomes of Pregnancy Following Surgery for Stress Urinary Incontinence: A Systematic Review

Mossanen¹,

Morrisroe²,

Pollard

et al. 2010

Journal of Urology

View full text Add to dashboard Cite

Purpose-Although few data have been published on the safety of childbearing after surgery for stress urinary incontinence, a large proportion of physicians recommend that women wait to complete childbearing before pursuing surgical treatment for stress urinary incontinence. We systematically reviewed the available literature to examine the safety of pregnancy after stress urinary incontinence surgery, and to measure the effect of such pregnancy on continence outcomes.Materials and Methods-The review was conducted according to the recommendations of the MOOSE (Meta-Analysis of Observational Studies in Epidemiology) group. We performed a systematic review to identify articles published before January 2011 on pregnancy after incontinence surgery. Databases searched include PubMed®, EMBASE® and the Cochrane Review. Our literature search identified 592 titles, of which 20 articles were ultimately included in the review.Results-Data were tabulated from case reports, case series and physician surveys. The final analysis in each category included 32, 19 and 67 patients, respectively. Urinary retention developed during pregnancy in 2 women, 1 of whom was treated with a sling takedown and the other with intermittent catheterization. Of these 2 women 1 also had an episode of pyelonephritis during pregnancy, possibly related to the intermittent catheterization. The incidence of postpartum stress urinary incontinence ranged from 5% to 18% after cesarean delivery and from 20% to 30% after vaginal delivery.Conclusions-Although the data on outcomes in the literature are limited and further studies need to be performed on the subject, the current data suggests that any increase in risks for pregnancy after surgery for stress incontinence may be small. A low risk of urinary retention during pregnancy may exist. Although some data suggest that cesarean deliveries may result in a lower rate of recurrent stress urinary incontinence than vaginal deliveries, a formal analysis could not be performed with the available data.

show abstract

Section: Data Abstraction and Synthesis Of Resultsmentioning

confidence: 99%

1765 Outcomes of Pregnancy Following Surgery for Stress Urinary Incontinence: A Systematic Review

Mossanen¹,

Morrisroe²,

Pollard

et al. 2010

Journal of Urology

View full text Add to dashboard Cite

show abstract

“…In a recent literature review (Anger et al, 2010) the authors systematically reviewed the efficacy and safety of botulinum toxin in the management of overactive bladder. Based upon this review of three small randomized placebo controlled trials they found that patients treated with botulinum toxin-A had 3.88 fewer incontinence episodes per day (95% CI -6.15, -1.62).…”

Section: Intravesical Botulinum Toxinmentioning

confidence: 99%

Diagnosis and Treatment of Overactive Bladder

Shaw¹,

Shaw²

2012

Urinary Incontinence

View full text Add to dashboard Cite

“…Among the 19 studies which were analyzed in their systematic review, only 6 included participants with idiopathic OAB and their sample sizes were small. Anger et al [5] published a systematic review in 2010 about botulinum toxin being used for idiopathic OAB. Only 3 RCTs were included in their review.…”

Section: Introductionmentioning

confidence: 99%

Botulinum Toxin-A Injections for Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis

Yu¹,

Wang²,

Liu³

et al. 2013

Urol Int

View full text Add to dashboard Cite

Objective: To review the current evidence on the efficacy and safety of botulinum toxin-A in the management of idiopathic overactive bladder (OAB). Methods: A systematic search of PubMed, Embase and the Cochrane Central Search Library was performed. All randomized controlled trials comparing botulinum toxin-A with placebo, different doses and injection techniques, in patients with idiopathic OAB was included. The analyzed outcomes were quantification of symptoms, urodynamic outcomes, quality of life and adverse events. Result: A total of 1,020 participants from 12 randomized controlled trials were included. Botulinum toxin-A was associated with less urinary frequency, less incontinence episodes, improvement in quality of life, higher post-void residual-related catheterization and higher urinary tract infection. Doses of 100-300 U were not consistently differentiated from each other in voiding diary, quality of life and urge urinary incontinence. No statistically significant difference was seen between bladder body and bladder base, bladder body and bladder body plus trigone in urinary retention and urinary tract infection. Conclusion: Botulinum toxin-A is associated with significant improvement in OAB symptoms in patients with idiopathic OAB. However, there is a higher incidence of postoperative urinary retention and urinary infection compared to placebo. Low-dose botulinum toxin-A seems to be the optimum dose that appropriately balances the benefits with adverse events. Trigone inclusion seems as safe and effective as trigone-sparing injection.

show abstract

Outcomes of Intravesical Botulinum Toxin for Idiopathic Overactive Bladder Symptoms: A Systematic Review of the Literature

Cited by 111 publications

References 19 publications

1765 Outcomes of Pregnancy Following Surgery for Stress Urinary Incontinence: A Systematic Review

1765 Outcomes of Pregnancy Following Surgery for Stress Urinary Incontinence: A Systematic Review

Diagnosis and Treatment of Overactive Bladder

Botulinum Toxin-A Injections for Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About