Outcomes of Intraocular Metastasis From Lung Cancer in the Era of Targeted Therapy: A Systematic Review and Pooled Analysis

Maller, Bradley; Salvatori, Sarah; Tanvetyanon, Tawee

doi:10.1016/j.cllc.2022.07.018

Cited by 6 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although intraocular metastases of lung cancer are rare, choroidal metastases are relatively common among intraocular metastases. A systematic review reported that 82% of the patients with intraocular metastases from lung cancer had choroidal metastases 3 . The symptoms of choroidal metastases include decreased vision, ocular pain, photopsia, floaters, and visual field defects.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review reported that 82% of the patients with intraocular metastases from lung cancer had choroidal metastases. 3 The symptoms of choroidal metastases include decreased vision, ocular pain, photopsia, floaters, and visual field defects. In the previous study of 17 cases of primary lung cancer with choroidal metastasis, 16 cases have been shown to have ocular symptoms as the initial manifestation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review

Matsuyama,

Oniwa,

Tsuruzono

et al. 2023

Respirology Case Reports

View full text Add to dashboard Cite

A 75‐year‐old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hilum. Following a detailed examination, the patient was diagnosed with primary lung adenocarcinoma (cT1cN3M1c Stage IVB) with choroid metastases. The tumour proportion score of programmed death ligand 1 (PD‐L1) was 1% and EGFR exon 20 insertion mutations were also detected. The patient was administered combination chemotherapy with nivolumab and ipilimumab. Primary lung and metastatic tumours, including the choroid, were reduced, and visual disturbances improved completely. Herein, we describe a rare case in which a combination of chemotherapy with nivolumab and ipilimumab significantly reduced vision loss due to choroidal metastasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review

Matsuyama,

Oniwa,

Tsuruzono

et al. 2023

Respirology Case Reports

View full text Add to dashboard Cite

show abstract

“…In their study, 45% of patients had targeted therapy with a median overall survival of 27 months and 92% had stable or improved vision. The use of targeted therapy was the strongest predictor of improved survival, and ocular radiotherapy was also associated with better outcome [ 36 ].…”

Section: Treatment Optionsmentioning

confidence: 99%

“…Because the anti-tumor response is not predictable, and choroidal metastasis will become too large and result in permanent ocular damage under inefficient systemic treatments, it is important to anticipate the use of local treatments and to limit the number of lines and cycles of chemotherapy before advocating for ocular radiotherapy or other effective local treatments. The survival benefit associated with radiotherapy in patients with choroidal metastases of lung cancer highlights the importance of this treatment [ 36 ].…”

Section: Treatment Optionsmentioning

confidence: 99%

How to Manage a Patient with Ocular Metastases?

et al. 2022

View full text Add to dashboard Cite

Ocular metastases are the most frequent ocular malignant tumors; their prevalence is estimated around 5–10% and is even higher in patients with breast or lung cancer. They represent various clinical situations, but they share the same hierarchical multidisciplinary therapeutic challenge with respect to the way systemic and local therapies should be selected in combination or sequentially in the personalized medical history of a patient. The challenges include tumor control, eye preservation, and the minimization of iatrogenic damage to sensitive tissues surrounding the tumor in order to preserve vision. These aims should further contribute to maintaining quality of life in patients with metastases. Many patients with choroidal metastases have systemic molecular treatment for their primary tumor. However, secondary resistance to systemic treatment is common and may ultimately be associated with cancer relapse, even after an initial response. Therefore, it makes sense to propose local treatment concomitantly or after systemic therapy to provide a more sustainable response. The aim of this review is to present current therapeutic strategies in ocular metastases and discuss how to tailor the treatment to a specific patient.

show abstract

“…Only 16% of lung cancer patients with uveal metastases were found to have small cell lung cancer as the histopathological type in a retrospective investigation of 194 patients ( 5 ). In a review of 92 patients with intraocular metastases from lung cancer, Maller et al ( 9 ) reported that 12 (13%) of the patients had a diagnosis of SCLC. Among the patients with the diagnosis of SCLC with ocular metastasis, 6 (50%) of them had iris metastasis.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Iris Metastasis in a Patient with Small Cell Lung Carcinoma: A Case Report

Ciftci

2024

Beyoglu Eye J

View full text Add to dashboard Cite

Small cell lung carcinoma (SCLC) is a neuroendocrine tumor with high probability of early disseminated disease and paraneoplastic syndromes. Choroid is the most common uveal tissue affected by metastatic disease followed by iris and ciliary body. Herein, we present a 46-year-old male with bilateral multiple iris metastasis. Once diagnosed, the patient already had diagnosis of SCLC with cranial and bone metastases.

show abstract

Outcomes of Intraocular Metastasis From Lung Cancer in the Era of Targeted Therapy: A Systematic Review and Pooled Analysis

Cited by 6 publications

References 12 publications

Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review

Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review

How to Manage a Patient with Ocular Metastases?

Bilateral Iris Metastasis in a Patient with Small Cell Lung Carcinoma: A Case Report

Contact Info

Product

Resources

About