Outcomes of idiopathic versus secondary nodular regenerative hyperplasia of the liver: A longitudinal study of 167 cases

Penrice, Daniel D.; Thakral, Nimish; Kezer, Camille A.; Lennon, Ryan J.; Moreira, Roger K.; Graham, Rondell P.; Kamath, Patrick S.; Simonetto, Douglas A.

doi:10.1111/liv.15202

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…Of the 87 full-text studies reviewed, 29 were included for data extraction. These included 17 studies pertaining to NRH in the native liver resulting in liver transplant or listing for liver transplant (6,7,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), and 11 studies pertaining to the development of NRH after liver transplantation (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Search Resultsmentioning

confidence: 99%

Nodular regenerative hyperplasia and liver transplantation: a systematic review

Biesterveld,

Schroder,

Hitchcock

et al. 2023

Front. Transplant.

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Nodular regenerative hyperplasia (NRH) is a primary disease of the liver that may cause noncirrhotic portal hypertension. Common causes include autoimmune, hematologic, immune deficiency, and myeloproliferative disorders. Given the limited data regarding the development of NRH in contemporary immunosuppressive protocols and the occurrence of NRH post-liver transplantation, we systematically reviewed NRH as it pertains to liver transplantation. We performed a comprehensive search for NRH and transplantation. Nineteen studies were identified with relevant data for NRH as an indication for a liver transplant. Thirteen studies were identified with relevant data pertaining to NRH development after liver transplant. Pooled analysis revealed 0.9% of liver transplant recipients had NRH. A total of 113 patients identified with NRH underwent liver transplantation. Most series report transplants done after the failure of endoscopic banding and TIPS management of portal hypertension. Reported 5-year graft and patient survival ranged from 73%–78% and 73%–90%. The pooled incidence of NRH after liver transplant for all indications was 2.9% and caused complications of portal hypertension. Complications related to portal hypertension secondary to NRH are a rare indication for a liver transplant. NRH can develop at any time after liver transplantation often without an identifiable cause, which may lead to portal hypertension requiring treatment or even re-transplantation.

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Section: Search Resultsmentioning

confidence: 99%

Nodular regenerative hyperplasia and liver transplantation: a systematic review

Biesterveld,

Schroder,

Hitchcock

et al. 2023

Front. Transplant.

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“…Due to the infrequent occurrence of NCPH, most of the previous studies were retrospective and multicentre, and this may affect the standards of evaluation. [6][7][8] A unique cohort of patients with established NCPH or at risk for NCPH due to an underlying diagnosis were followed prospectively with routine laboratory testing and imaging at the National Institutes of Health Clinical Center. The aim of the study was to evaluate the outcomes in the cohort as well as identify markers that may predict the outcome.…”

Section: Introductionmentioning

confidence: 99%

“…The diagnostics, mechanisms and natural history of NCPH are not fully explored. Due to the infrequent occurrence of NCPH, most of the previous studies were retrospective and multicentre, and this may affect the standards of evaluation 6–8 . A unique cohort of patients with established NCPH or at risk for NCPH due to an underlying diagnosis were followed prospectively with routine laboratory testing and imaging at the National Institutes of Health Clinical Center.…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of patients with non‐cirrhotic portal hypertension: A single centre study

Mironova,

Gopalakrishna,

Viana Rodriguez

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgroundNon‐cirrhotic portal hypertension (NCPH) is a spectrum of liver diseases, including porto‐sinusoidal vascular disorder, with portal hypertension (PH) in the absence of cirrhosis. The natural history and diagnostic approach to NCPH are not well understood.AimWe aimed to evaluate disease progression and outcomes in NCPH.MethodsPatients with or at risk for NCPH were enrolled in a single centre prospective study; two groups were formed based on the presence of specific features of PH, such as varices, collaterals, portal hypertensive gastropathy or portal hypertensive bleeding. All participants underwent a baseline liver biopsy. Liver stiffness measurement (LSM), and imaging were repeated every 6–12 months.ResultsFifteen patients without specific features of PH (Group I), and 35 patients with specific features (Group II) were enrolled. The median follow‐up time was 50 months. Group II had higher hepatic venous pressure gradients, non‐invasive measures of PH and a lower platelet count (PLT) when compared to Group I. Rates of survival and decompensation were similar in both groups. Patients with PLT ≤100 K/mcL had lower survival compared to those with PLT >100 K/mcL. Patients with LSM ≥10 kPa had lower survival and survival without decompensation when compared to patients with LSM <10 kPa.ConclusionsPatients irrespective of specific features of PH had similar survival or survival without decompensation. Patients without specific features are at risk for disease progression and should be monitored closely. Thrombocytopenia and increased LSM are associated with severe forms of liver disease, which are strongly associated with outcomes.

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Bleomycin/tioguanine

2022

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Outcomes of idiopathic versus secondary nodular regenerative hyperplasia of the liver: A longitudinal study of 167 cases

Cited by 7 publications

References 19 publications

Nodular regenerative hyperplasia and liver transplantation: a systematic review

Nodular regenerative hyperplasia and liver transplantation: a systematic review

Prospective evaluation of patients with non‐cirrhotic portal hypertension: A single centre study

Bleomycin/tioguanine

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