Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus

Wong, Tiffany Cho‐Lam; Cheung, Tan To; Chok, Kenneth S. H.; Chan, Albert C. Y.; Dai, Wing Chiu; Chan, See Ching; Poon, Ronnie T. P.; Fan, Sheung Tat; Lo, Chung Mau

doi:10.1111/hpb.12368

Cited by 28 publications

(58 citation statements)

References 27 publications

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“…7,8,12 In our current series, the 5-year survival rate of HCC patients with BDTT was 36.6%, and there was no significant difference in survival between HCC patients with or without BDTT when the two groups were matched by stage. Wong et al also reported that HCC patients with or without BDTT demonstrated similar survival rates using their matching criteria.…”

Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 46%

“…Wong et al also reported that HCC patients with or without BDTT demonstrated similar survival rates using their matching criteria. 7 Macrovascular invasion, including portal vein invasion and hepatic vein invasion, is correlated with poor prognosis in HCC patients. [13][14][15][16][17] Regarding BDTT, in contrast, Esaki et al reported that macroscopic bile duct invasion demonstrates a favorable impact on patient outcomes in HCC patients with BDTT.…”

Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 99%

“…Wong et al proposed extrahepatic bile duct resection for HCC with BDTT in order to minimize bile duct recurrence. 7 However, according to several reports, routine bile duct resection is not recommended unless direct invasion of the BDTT into the bile duct is suspected. 8,12,18 Shiomi et al reported that the survival of their bile duct-preserved group was similar to that of their bile duct-resected group.…”

Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 99%

“…[6][7][8] However, it is presently unclear whether or not surgical treatment is valid for HCC with BDTT that presents with obstructive jaundice because the short-and long-term outcomes of such cases are unknown. In addition, the optimal surgical approach for HCC patients with BDTT-whether or not to preserve the bile duct -is also unclear.…”

Section: Introductionmentioning

confidence: 99%

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Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice

et al. 2016

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SynopsisHepatectomy should be considered for hepatocellular carcinoma with bile duct tumor thrombus.3 Abstract Purpose: The purpose of this study was to evaluate the short-and long-term outcomes of hepatectomy for hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT), including cases with obstructive jaundice. Methods:We reviewed 42 HCC patients with BDTT, including 6 patients who needed preoperative biliary drainage due to obstructive jaundice and 732 HCC patients without BDTT. We analyzed the impact of BDTT on the surgical outcomes and assessed the outcomes of hepatectomy for patients presenting with obstructive jaundice.

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Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 46%

Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 99%

Section: -8 Yeh Et Al Reported the Relationship Between The Pathogenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice

et al. 2016

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“…Studies have found many risk factors of the recurrence of hepatocellular carcinoma after resection, including hepatitis B virus infection, tumor diameter, tumor number, tumor capsule, vascular invasion, portal vein tumor thrombus, surgical margin width, intraoperative bleeding and blood transfusion. [9][10][11] It has been reported that 1-year and 2-tear recurrence rates of HCC in our country are 38.7% and 57.9%, respectively. 12 In this study, 1-year and 2-tear recurrence rates of patients with HCC in caudate lobe were 44.4% and 88.9%, significantly higher than average recurrence rate as mentioned above, suggesting that the prognosis of surgical treatment of HCC in the caudate lobe is worse than that of HCC in other parts of liver, consistent with the results of similar studies.…”

Section: Discussionmentioning

confidence: 99%

Treatment for hepatocellular carcinoma in the caudate lobe: a report of 13 cases

Zhang¹,

Wu²,

You³

et al. 2017

Int Surg J

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INTRODUCTIONPrimary hepatocellular carcinoma (HCC) is one of the most common digestive tract tumors, and surgical resection is the preferred therapeutic method of HCC. However, as caudate lobe is located in the middle of the back of liver, surrounded by a large number of large vessels, it is difficult and risky to resect.1 Many doctors attempted to adopt TACE-based non-operative method for the treatment of HCC located in the caudate lobe, but its clinical effects are controversial. In addition, with the continuous improvement of surgical approach, surgical method and surgical instruments, there are more and more reports on caudate lobe resection, but the long-term ABSTRACT Background: To investigate therapies of hepatocellular carcinoma in the caudate lobe, surgical approach and method, surgical outcome of hepatic caudate lobotomy. Methods: Clinical data of 13 patients with hepatocellular carcinoma in the caudate lobe who received surgical treatment in the Department of Hepatobiliary Surgery of the Second Affiliated Hospital of Chongqing Medical University from Jan 2010 to Jan 2014 was retrospectively analyzed. Results: Two patients selected TACE therapy. However, tumor metastasis was observed on them in short term, and the therapeutic effect was poor after several times of treatment. Nine patients received surgical treatment. Surgical approaches included left approach, right approach and combined approaches from the left and right side; surgical method was part or complete caudate lobe resection combining with other liver segments. The operation time was 220.0-350.0 minutes, with the average value of 259.4 minutes. The vascular clamping time was 21.0-45.0 minutes, with the average value of 30.2 minutes. The bleeding volume was 400.0-1800.0 ml, with the average value of 844.4 ml. In all patients, there was no perioperative death and no postoperative liver failure happened, and 4 patients who suffered from interrelated complications were cured or got better by conservative treatments. All patients were followed up for 24 months. The recurrent rates of 1 and 2-year were 44.4%, 88.9% respectively, and the survival rates of 1 and 2 year were 66.7%, 44.4% respectively after surgical resection. Conclusions: Resection is still the preferred therapeutic method for hepatocellular carcinoma in the caudate lobe. However, long-term outcomes of the therapy for hepatocellular carcinoma in the caudate lobe need further improvement.

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Current topics in the surgical treatments for hepatocellular carcinoma

Ban

Ogura

Akahoshi

et al. 2018

Annals of Gastroent Surgery

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Treatment strategy for hepatocellular carcinoma (HCC) requires optimal selection of therapies based on various factors related to tumor condition and liver functional reserve. Although several evidence‐based guidelines have been proposed for the treatment of HCC, the criteria and range of indications differ among these guidelines according to the circumstances of each country. In European nations and the USA, patients with the Barcelona Clinic Liver Cancer stage 0‐A are subjects for surgical resection, whereas in Asian countries, even those with the intermediate stage are regarded as surgical candidates. Furthermore, since the recent introduction and rapidly widely spreading use of laparoscopic liver resection, this technique has become an important treatment option for surgical resection. In this review article, we overview the current topics of treatment of HCC with a special focus on surgical therapy.

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Outcomes of hepatectomy for hepatocellular carcinoma with bile duct tumour thrombus

Abstract: A major hepatectomy, extrahepatic biliary resection and hepaticojejunostomy should be the standard for HCC with BDTT, and long-term survival is possible after radical surgery.

Cited by 28 publications

References 27 publications

Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice

Hepatectomy for Hepatocellular Carcinoma with Bile Duct Tumor Thrombus, Including Cases with Obstructive Jaundice

Treatment for hepatocellular carcinoma in the caudate lobe: a report of 13 cases

Current topics in the surgical treatments for hepatocellular carcinoma

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