Outcomes of Early Endoscopic Realignment Versus Suprapubic Cystostomy and Delayed Urethroplasty for Pelvic Fracture-related Posterior Urethral Injuries: A Systematic Review

Elshout, Pieter Jan; Veskimäe, Erik; MacLennan, Steven; Yuan, Yuhong; Lumen, Nicolaas; Gonsalves, Michael; Kitrey, Noam D.; Sharma, Divya; Summerton, Duncan J.; Kuehhas, Franklin E.

doi:10.1016/j.euf.2017.03.001

Cited by 24 publications

(15 citation statements)

References 26 publications

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“…Bladder drainage should be obtained soon and as safe and technically feasible. In case of contrast extravasation on urethrogram, a suprapubic catheter should be considered [57, 226].…”

Section: Methodsmentioning

confidence: 99%

“…However, the insertion of a suprapubic catheter may be difficult due to hematoma or to poor bladder filling in case of shock; an experienced provider may attempt once a careful urethral catheter placement [58, 60, 61, 67, 120, 125, 126, 226]. However, if any resistance is encountered, a suprapubic catheter should be placed under direct visualization or with ultrasound guidance [120].…”

Section: Methodsmentioning

confidence: 99%

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Kidney and uro-trauma: WSES-AAST guidelines

et al. 2019

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Renal and urogenital injuries occur in approximately 10-20% of abdominal trauma in adults and children. Optimal management should take into consideration the anatomic injury, the hemodynamic status, and the associated injuries. The management of urogenital trauma aims to restore homeostasis and normal physiology especially in pediatric patients where non-operative management is considered the gold standard. As with all traumatic conditions, the management of urogenital trauma should be multidisciplinary including urologists, interventional radiologists, and trauma surgeons, as well as emergency and ICU physicians.

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“…Bladder drainage should be obtained soon and as safe and technically feasible. In case of contrast extravasation on urethrogram, a suprapubic catheter should be considered [57, 226].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Kidney and uro-trauma: WSES-AAST guidelines

et al. 2019

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“…Urethral stricture is a challenging and common problem in urology. 1 – 3 The mechanism of this fibrotic disease is unclear, and both its surgical and medical management remain unsatisfactory. Quality of life is significantly affected in patients with urethral stricture.…”

Section: Introductionmentioning

confidence: 99%

Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

Chen

et al. 2018

DDDT

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PurposeTo examine the effects and mechanism of action of fasudil on cytoskeletal polymerization, collagen synthesis, and apoptosis in fibroblasts derived from human urethral scar tissue.Materials and methodsFibroblasts treated with or without transforming growth factor β1 (TGF-β1, 10 ng/mL) were incubated with fasudil (12.5, 25, 50 μmol/L) for 24 hours. Quantitative real-time polymerase chain reaction and Western blotting were used to determine the expression of Arp2, Arp3, WASP, and WAVE2. Collagen I and III protein levels were also evaluated by Western blotting. The filamentous actin cytoskeleton was examined by immunofluorescence and epifluorescence microscopy. An Annexin V-FITC/PI staining assay was used to investigate apoptosis.ResultsTGF-β1-dependent induction of actin polymerization and collagen synthesis and promotion of apoptosis were dose dependent. When compared with untreated controls, fasudil significantly decreased the expression of Arp2, Arp3, WASP, WAVE2, Collagen I, and Collagen III in cells treated with or without TGF-β1. Fasudil also promoted apoptosis in cells, irrespective of TGF-β1 treatment.ConclusionIrrespective of TGF-β1 activation status, fasudil suppressed actin polymerization and collagen synthesis and induced apoptosis in human urethral scar fibroblasts via the Rho/ROCK signaling pathway.

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“…To predict the functional outcome, anorectal manometry can be performed prior to colostomy reversal (2). In men, blunt pelvic trauma with pelvic ring injury causes posterior urethral injury (PUI) in up to 10% of patients, and long-term morbidity due to PUIs is associated with urethral stricture, erectile dysfunction, and urinary incontinence (3,4). In our patient, we performed suprapubic cystostomy because urethral catheterization failed.…”

Section: Discussionmentioning

confidence: 90%