Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review

Hassan, Omron; Phan, Sheshanna; Wiecks, Nicole; Joaquin, Christian; Бондаренко, В. В.

doi:10.1007/s10143-020-01415-y

Cited by 28 publications

(30 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, deep brain stimulation (DBS) is a treatment that involves targeted delivery of electricity to a select brain region using an implanted electrode. The NAc is a target for DBS treatment in multiple conditions including obsessive compulsive disorder (OCD) ( Koya et al, 2009 ), treatment-resistant bulimic anorexia nervosa ( Fernandes Arroteia et al, 2020 ), and substance use disorders ( Hassan et al, 2020 ). While the precise mechanism by which DBS relieves symptoms remains elusive, an improved understanding of how NAc circuitry controls of behavior may inform more targeted manipulation of specific neural elements or circuits at distinct time points in conjunction with pharmacotherapies.…”

Section: Conclusion Caveats and Future Directionsmentioning

confidence: 99%

Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release

Covey

Yocky

2021

Front. Synaptic Neurosci.

View full text Add to dashboard Cite

The nucleus accumbens (NAc) is located in the ventromedial portion of the striatum and is vital to valence-based predictions and motivated action. The neural architecture of the NAc allows for complex interactions between various cell types that filter incoming and outgoing information. Dopamine (DA) input serves a crucial role in modulating NAc function, but the mechanisms that control terminal DA release and its effect on NAc neurons continues to be elucidated. The endocannabinoid (eCB) system has emerged as an important filter of neural circuitry within the NAc that locally shapes terminal DA release through various cell type- and site-specific actions. Here, we will discuss how eCB signaling modulates terminal DA release by shaping the activity patterns of NAc neurons and their afferent inputs. We then discuss recent technological advancements that are capable of dissecting how distinct cell types, their afferent projections, and local neuromodulators influence valence-based actions.

show abstract

Section: Conclusion Caveats and Future Directionsmentioning

confidence: 99%

Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release

Covey

Yocky

2021

Front. Synaptic Neurosci.

View full text Add to dashboard Cite

show abstract

“…This has shown efficacy in the treatment of other neurological syndromes, including SUD and OCD. [ 4 , 17 ] Furthermore, DBS treatment for ED has been summarized above to have minimal adverse effects and complications, as only 4.7% (3/64) of the total patients suffered from serious adverse effects. This is only slightly higher than the complication rate from serious adverse effects in DBS for the treatment of SUD, which is only 3.0% (1/33)[ 17 ] of the total patients.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 , 17 ] Furthermore, DBS treatment for ED has been summarized above to have minimal adverse effects and complications, as only 4.7% (3/64) of the total patients suffered from serious adverse effects. This is only slightly higher than the complication rate from serious adverse effects in DBS for the treatment of SUD, which is only 3.0% (1/33)[ 17 ] of the total patients. This difference may be attributed to the difference in sample sizes and/or the wide variation in stimulation areas in the ED studies as compared to the SUD studies.…”

Section: Discussionmentioning

confidence: 99%

“…This difference may be attributed to the difference in sample sizes and/or the wide variation in stimulation areas in the ED studies as compared to the SUD studies. [ 17 ] The SUD studies all had a common stimulation parameter at the Nac. The wide variation in stimulation coordinates and parameters seen across all studies highlights the need to do further work in researching the neural pathways involved in ED.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The utility of deep brain stimulation surgery for treating eating disorders: A systematic review

Potes¹,

Joaquin

Wiecks

et al. 2021

Surgical Neurology International

Self Cite

View full text Add to dashboard Cite

Background: Deep brain stimulation (DBS) has demonstrated preliminary success as a treatment for neuropsychological disorders including obsessive-compulsive disorder and substance use disorder. This systematic review aims to assess the use of DBS in treating eating disorders (EDs) to determine its utility and the extent of adverse effects. Methods: A PubMed search following PRISMA guidelines was executed to find studies encompassing DBS as a treatment of ED. Outcomes were extracted from the literature and summarized while a review of quality was also performed. Results: From a search yielding 299 publications, 11 studies published between 2010 and 2020 were found to fit the inclusion criteria. Out of 53 patients who began with an abnormal BMI before treatment, 22 patients (41.5%) achieved normal BMI on follow-up. Significant neuropsychological improvement was seen in most patients as measured by neuropsychiatric testing and questionnaires. Conclusion: DBS as a treatment for ED may result in significant objective and psychological benefits. Further studies should aim to increase the sample size, standardize follow-up protocol, and standardize the neuropsychiatric tests used to determine psychological and physiological benefits.

show abstract

“…It can be claimed that there are more conducted studies about the effect of active DBS on heroin consumption or craving in heroin-dependent participants, than the other substance use disorder studies. Common results of these studies showed that targeting the nucleus accumbens had demonstrated a significant decrease in cravings and consumption, as well as increase in abstinent participants [44].…”

Section: Alcohol and Substance Use Disordersmentioning

confidence: 99%

Deep brain stimulation for psychiatric disorders: A review

Boztaş¹,

Yenice²

2021

2791-6332

View full text Add to dashboard Cite

Deep Brain Stimulation (DBS) is a neurosurgical procedure via the placement of neurostimulator, which is a medical device also known as brain pacemaker. The electrical impulses, which are sent to s pecific targets of brain through implanted electrodes, used in the treatment of some neurological and psychiatric disorders. While the mechanisms of action of DBS on the physiology on brain cells and neurotransmitters are controversial, it is well known that high-frequency electrical impulses into specific brain areas can diminish certain symptoms of some neurological and psychiatric disorders. DBS is already approved as a treatment for several neurological disorders by the Food and Drug Administration (FDA). It is approved as a treatment for essential tremor in 1997 and Parkinson's disease since 2002, for dystonia in 2003 and for epilepsy in 2018. There are also variety uses of DBS in psychiatric disorders with resistance to treatment, such as obsessive compulsive disorder, Tourette's syndrome, major depressive disorder, post-traumatic stress disorder, appetite disorders, alcohol and substance use disorders and also schizophrenia. This article outlines using of deep brain stimulation as a treatment method for psychiatric disorders which are resistant to medical treatments and psychotherapies, as well as the appropriate anatomical targets and the possible mechanism of actions.

show abstract

Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review

Cited by 28 publications

References 69 publications

Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release

Endocannabinoid Modulation of Nucleus Accumbens Microcircuitry and Terminal Dopamine Release

The utility of deep brain stimulation surgery for treating eating disorders: A systematic review

Deep brain stimulation for psychiatric disorders: A review

Contact Info

Product

Resources

About