Outcomes of COVID-19 Patients Hospitalized in a University Hospital, Turkey

Türe, Zeynep; Ünüvar, Gamze Kalın; Ketenciogu, Burcu Baran; Zarasız, Gökmen; Tok, Tuğba Taşkın; Temel, Şahin; Tutar, Nuri; Gündoğan, Kürşat; Gökahmetoğlu, Selma; Aygen, Bilgehan; Yıldız, Orhan

doi:10.36519/idcm.2020.0020

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…In association, there is an increase in D-dimer levels. Studies have indicated that increases in D-dimer levels are an important marker to detect critical disease early (26,27). In this regard, our study supports the literature.…”

Section: Discussionsupporting

confidence: 90%

Predictors of Severity and Mortality in COVID-19: A Retrospective Study from Batman, Turkey

Akgül¹,

Sevim²,

Arslan³

et al. 2022

Infect Dis Clin Microbiol

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Objective: It is increasingly important to identify risk factors for COVID-19-associated mortality to provide access to early treatment. This study aimed to investigate the relationship between COVID-19 severity and laboratory data and demographic characteristics of hospitalized patients and to identify factors predicting mortality in COVID-19. Materials and Methods:The study is a retrospective and single-center study. Data of 1298 COVID-19 patients confirmed by a positive real-time polymerase chain reaction test for COVID-19 and treated at the hospital were retrospectively analyzed. Study patients were divided into three groups based on the clinical severity of disease: the mild-moderate group (n:954) and the severe (n:310) and critical (n:34) groups. Demographic characteristics, underlying diseases, and laboratory findings were compared between groups.Results: Multivariate logistic and ordinal logistic regression analysis revealed that male gender, old age, diabetes mellitus, coronary artery disease, cerebrovascular event, malignancy, chronic obstructive pulmonary disease, chronic renal failure, chronic hepatitis B, and Alzheimer's disease/dementia/Parkinson's disease (among neurological diseases) were independently associated with and significantly increased the development of severe disease and mortality. Conclusion:The COVID-19 pandemic continues to be a significant health problem affecting all of humanity. Determining risk factors for COVID-19 severity and mortality are critical for classifying critical cases at the time of initial diagnosis, establishing appropriately specific treatment protocols, and ensuring access to early treatment.

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Section: Discussionsupporting

confidence: 90%

Predictors of Severity and Mortality in COVID-19: A Retrospective Study from Batman, Turkey

Akgül¹,

Sevim²,

Arslan³

et al. 2022

Infect Dis Clin Microbiol

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“…14% of 157 individuals were diagnosed with diabetes mellitus (DM). 38 In USA a study conducted where it showed the prevalent of diabetes was 58% with the average age of the patients was 64, 63% were males, 39 while another survey showed 10.9%. 40 Another study conducted for a short period of time where the prevalence is found to be above 50%.…”

Section: Literature Review 131 Review Of Related Literaturementioning

confidence: 99%

Prevalence of COVID-19 Among Older People with Type 2 Diabetes Mellitus: A Systematic Review

Junhai

Saha

Sarkar

2022

Int J Sci Healthcare Res

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Background: On March 11, 2020, the WHO proclaimed the Coronavirus Disease 2019 (COVID-19) pandemic owing to coronavirus-2 (SARS-CoV-2). SARS-CoV-2 is a zoonotic virus that may be spread from bats to humans through airborne droplets and aerosols. SARS-CoV-2 spike protein has a high binding affinity for ACE2 receptors, widely expressed throughout the respiratory system, notably in epithelial lung cells. ACE2 receptors are found in intestinal mucosal, endothelial, heart, renal epithelial as well as cerebral neuronal cells, explaining COVID-19 extrapulmonary symptoms like diarrhea, nausea, vomiting, chest pain, heart failure, renal injury, headache, and confusion. Older persons with type2 diabetes mellitus and hypertension are more susceptible to SARS-CoV-2 infection as drugs by which they are treated promote ACE2 receptor expression. Moreover, comorbidities increase the probability of poor outcomes after infection by the SARS-CoV-2. Research links COVID-19 to hyperglycemia in the elderly with type 2 diabetes. Twenty percent of people with diabetes get severe pneumonia and a septic course from viral infections. Diabetes contributed to sickness severity and fatality in MERS (MERS-CoV). Epidemiological findings in SARS-CoV-2-affected regions, CDC data, and other national health centers and hospitals suggest that individuals with diabetes had a 50% greater chance of dying from COVID-19. Methods: This systematic review involves a critical and reproducible summary of the results of the available publications on COVID-19 and diabetic elderly patients’ topics and questions. Fourteen studies (6 retrospective cohorts, two prospective, two cohorts, one combined retrospective, one observational, one cross-sectional, and one hospital-based study) were included in this systematic review. Results: From all studies, the mean age of older adults with type 2 diabetes mellitus who suffered from COVID-19 was 50 to 89 years. The majority of the studies showed the male predominance of infection. The pooled prevalence of COVID-19 among diabetes mellitus elderly patients was 29.8%. Conclusions: Diabetes patients had a greater COVID-19 prevalence and severity, according to several explanations. Diabetes Mellitus increases the risk of infection due to innate and adaptive immunity deficiencies. Post COVID-19 complications arise due to a lack of equilibrium between pro-inflammatory and anti-inflammatory cytokine networks in type 2 diabetes mellitus, contributing to increased mortality. Therefore, this study necessitates a large investigational study to find out how to boost the immune response against SARS-CoV-2 infection in an equilibrium manner not to produce much inflammatory cytokine in type 2 diabetes mellitus individuals to reduce the risk of developing complications and mortality consequently. Keywords: COVID-19, Diabetes mellitus, Type-2 diabetes, Elderly.

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The Effect of Change in Discharge Criteria on Prognosis and Cost in Patients With Covid-19

Türe¹,

YETİKCAN²,

ÜNÜVAR³

et al. 2023

Sağlık Bilimleri Dergisi

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Haziran 2020 tarihinde normalleşme sürecine geçilmesi ile koronavirüs hastalığı-2019 (COVID-19) tedavisi tamamlanan hastaların tedavi sonrası polimeraz zincir reaksiyonu testi negatifliği beklenmeden taburcu edilmesi kararı alınmıştır. Bu çalışmada uygulama öncesi ve uygulama sonrası birer aylık periyotlardaki hasta profili, hastanede yatış süresi ve maliyetin karşılaştırılması planlandı. 15 Haziran 2020 öncesi (birinci grup) ve sonrası (ikinci grup) birer aylık süreçlerde pandemi servisinde COVID-19 olası ve kesin tanısı ile takip edilen hastaların demografik verileri, ko-morbiditeleri, laboratuvar bulguları, tedavi, prognoz ve tedavi maliyetleri karşılaştırıldı. Çalışmaya birinci gruptan 46, ikinci gruptan 49 olmak üzere toplam 95 hasta dâhil edildi. Birinci grupta kesin vaka oranı %37 iken bu oran ikinci grupta %59’du (p=0.040). Kesin vaka tanımına uyan hastalarda birinci grubun hastanede yatış süresi ortancası ikinci gruba göre daha uzundu (Grup 1 için; 10 (3-21), Grup 2 için; 6 (3-12) gün, p=0.003). İkinci gruptaki hastalarda COVID-19 ile uyumlu tipik tomografi bulgu oranı daha yüksekti (Grup 2 için %52 ve Grup 1 için %26, p=0.018). İlk grupta hidroksiklorokin ile tedavi oranı ikinci gruba göre daha yüksek iken (Grup 1 için %72 ve Grup 2 için %41, p=0.004) ikinci grupta favipiravir ile tedavi oranı daha fazla idi (Grup 2 için %55 ve Grup 1 için %17, p=0.001). Birinci grupta tedavi maliyeti ortancası 2798 (661-45465) Türk Lirası (TL), ikinci grupta ise 1627 (748-4496) TL idi (p=0.001). COVID-19 tanılı hastaların tedavi sonrası izolasyon sürelerini hastane dışında tamamlaması hastane maliyetinin azaltılması açısından anlamlıdır.

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Outcomes of COVID-19 Patients Hospitalized in a University Hospital, Turkey

Cited by 3 publications

References 25 publications

Predictors of Severity and Mortality in COVID-19: A Retrospective Study from Batman, Turkey

Predictors of Severity and Mortality in COVID-19: A Retrospective Study from Batman, Turkey

Prevalence of COVID-19 Among Older People with Type 2 Diabetes Mellitus: A Systematic Review

The Effect of Change in Discharge Criteria on Prognosis and Cost in Patients With Covid-19

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