Outcomes of Corneal Topography among Progressive Keratoconus Patients 12 months following Corneal Collagen Cross-Linking

Alqahtani, Bader; Alshahrani, Saeed; Khayyat, Waleed; Abdalla-Elsayed, Maram E A; Altalhi, Abdullah A; Saifaldein, Amjad Ameen; Taha, Mohammed A.

doi:10.2147/opth.s284981

Cited by 3 publications

(4 citation statements)

References 32 publications

(16 reference statements)

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“…The current study revealed a significant drop in the central and corneal thickness at the beginning of the observation period followed by a rise in the MCT and CCT values. The results are in line with previous studies that reported a continuous decrease in pachimetry values within the first year after CXL [21,22]. In a year, the corneal thickness steadily increased and returned to the baseline [23].…”

Section: Pachymetry After Corneal Collagen Cross-linkingsupporting

confidence: 92%

Structural Outcomes of Corneal Cross-Linking for Keratoconus

Statsenko,

Smetanina,

Voitetskii

et al. 2024

Preprint

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Background: Studies have tried to identify predictors of functional markers of keratoconus progression, whereas structural outcomes of collagen cross-linking have not been properly investigated. Objective: find and set up a combination of diagnostic modalities and measurements to reliably reflect CXL efficiency. Material and methods: We retrospectively reviewed the medical histories of 107 KC patients (131 eyes) who underwent CXL in a medical center from January 2018 to December 2022. The dataset included preoperative examinations and follow-up results, which provided a total of 796 observations. The cases of other corneal diseases, repeated CXL, pregnancy, and observations without follow-up examinations were excluded. Results: The study findings revealed a significant drop in the central and corneal thickness during 14.01±9.98 months of observations. Linear and polynomial equations suggested different trends in pachymetry change after CXL. The linear model showed corneal thinning, and according to the polynomials, pachymetry findings return to baseline values two years after CXL. Conclusion: The most reliable prognosis of postoperative corneal thickness is achieved with the models trained on keratometry readings and topography indices. BAD indices are also reliable predictors of the corneal thickness after CXL. A combination of the aforementioned structural parameters and their derivatives can reliably predict CXL efficiency.

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Section: Pachymetry After Corneal Collagen Cross-linkingsupporting

confidence: 92%

Structural Outcomes of Corneal Cross-Linking for Keratoconus

Statsenko,

Smetanina,

Voitetskii

et al. 2024

Preprint

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“… 1 Keratoconus affects 1 out of every 2000 persons on the planet. 1 , 2 Its annual incidence rates in Asian and white populations are 25/100,000 and 3.3/100,000, respectively; 10% of those afflicted have a positive family history. 1 , 3 …”

Section: Introductionmentioning

confidence: 99%

“… 6 Under aseptic conditions and with adequate pain relief, the central 7–9 mm corneal epithelium is removed, and a solution containing 0.1% riboflavin, 10 ml of 20% dextran, and 10 mg of riboflavin-5-phosphate is applied for half an hour, followed by exposure to 370 nm UVA at an irradiance of 3mW/cm2 for another half hour. 2 , 7 …”

Section: Introductionmentioning

confidence: 99%

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Outcomes of Corneal Topographical Kmax readings 3 months after Corneal Cross Linkage in Keratoconus patients

Sangah¹,

Kumari²,

Mumtaz³

et al. 2022

Journal of Community Hospital Internal Medicine Perspectives

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Background and objective Collagen protein, which is abundant in the cornea and has a triple helix form, may be found in almost every tissue matrix in the body. Natural cross connections between monomers provide the robustness of the helical protein structure. Wollensak and his colleagues developed the Dresden Protocol, a keratoconus treatment based on Corneal Cross-Linkage. We aimed to analyse and present the findings in individuals with progressive keratoconus using topographic and refractive results after corneal collagen crosslinking treatment (CXL) (KC) after 3 months. Methods The study comprises a total of 100 patients who were diagnosed with progressive KC and who underwent CXL between 2021 and 2022 at KRL Hospital Islamabad, Pakistan. All eyes in this study had a preoperative topography within 1 month before CXL treatment and the follow-ups were conducted at 3 months interval. Results In our investigation, 100 patients were added. The average age was 24.74 years. 77% of the patients were between the ages of 12 and 25 years, while 23% were between the ages of 26 and 50 years. In our survey, males made up 84% of the population, while females made up only 16%. The right eye was afflicted in 60% of cases, whereas the left eye was impacted in 40% of the population. Grade 2 Keratoconus affected 42% of patients, whereas Grade 1 Keratoconus affected 18%. Our findings were skewed toward men and the 12–25 age group, however in our recent study, we discovered considerable KC stability 3 months after CXL. Conclusion Keratometric readings and visual acuity were stabilised or improved with CXL treatment. Keratoconus stability can be reached 3 months following the treatment, according to our findings.

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