Outcomes of Cervical Cancer and Positive Para-aortic Lymph Nodes in the Modern Era of Chemoradiation

Abstract

Our study shows a median OS of 23 months, which is less than what was documented in the literature. Despite the use of modern chemoradiation therapy, most of the cohort died within 3 years. The low OS presented in our study highlights the limitations of the current treatment regimens and the need for identification of for more effective therapy.

Neoadjuvant Chemotherapy in Locally Advanced Cervical Carcinoma – a Role in Patients with Para-aortic Lymph Node Involvement? A 10-year Institutional Experience

“…Recent European Society of Gynaecological Oncology (ESGO) guidelines recommend that patients with paraaortic lymph node metastases, or those at high-risk of microscopic involvement, are treated with extended-field chemoradiation, [5]. A retrospective review of 175 patients with pathology-proven paraaortic lymph nodes receiving extended-field radiotherapy reported a median OS of just 23.4 months; the majority died within 3 years, [6]. The authors highlighted current limitations of treatment and the need for more effective therapy.…”